Top articles since 2010

Rank Title Journal Year PubWeight™‹?›
1 MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011 220.97
2 Global cancer statistics. CA Cancer J Clin 2011 185.92
3 Crystal structure refinement with SHELXL. Acta Crystallogr C Struct Chem 2015 158.65
4 Hallmarks of cancer: the next generation. Cell 2011 140.01
5 A map of human genome variation from population-scale sequencing. Nature 2010 121.13
6 MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol 2013 112.81
7 PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 2010 108.52
8 Cancer statistics, 2010. CA Cancer J Clin 2010 103.28
9 The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 2010 97.51
10 Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010 90.16
11 Features and development of Coot. Acta Crystallogr D Biol Crystallogr 2010 89.46
12 Cancer statistics, 2012. CA Cancer J Clin 2012 87.38
13 QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010 85.34
14 Cancer statistics, 2013. CA Cancer J Clin 2013 84.72
15 NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012 84.41
16 Fast gapped-read alignment with Bowtie 2. Nat Methods 2012 83.79
17 A method and server for predicting damaging missense mutations. Nat Methods 2010 78.53
18 Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010 75.21
19 Cancer statistics, 2014. CA Cancer J Clin 2014 72.81
20 Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011 69.36
21 Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr 2011 67.55
22 XDS. Acta Crystallogr D Biol Crystallogr 2010 67.46
23 Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010 67.34
24 Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios. Transl Androl Urol 2016 66.58
25 GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Bioinformatics 2012 65.14
26 An integrated encyclopedia of DNA elements in the human genome. Nature 2012 64.73
27 Differential expression analysis for sequence count data. Genome Biol 2010 64.56
28 SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol 2012 62.36
29 An integrated map of genetic variation from 1,092 human genomes. Nature 2012 59.82
30 A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet 2011 59.36
31 Cancer statistics, 2015. CA Cancer J Clin 2015 57.51
32 Fiji: an open-source platform for biological-image analysis. Nat Methods 2012 56.92
33 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 56.72
34 Multiplex genome engineering using CRISPR/Cas systems. Science 2013 55.53
35 Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 2011 53.86
36 Global cancer statistics, 2012. CA Cancer J Clin 2015 53.52
37 New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 2010 53.37
38 BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 2010 53.23
39 Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012 52.99
40 Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 2010 52.01
41 Search and clustering orders of magnitude faster than BLAST. Bioinformatics 2010 51.97
42 A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 50.94
43 Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010 50.58
44 Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010 50.17
45 RNA-guided human genome engineering via Cas9. Science 2013 48.29
46 A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012 48.17
47 Integrated genomic analyses of ovarian carcinoma. Nature 2011 47.72
48 Comprehensive molecular portraits of human breast tumours. Nature 2012 47.39
49 Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011 45.46
50 Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012 44.56
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