Top articles since 2011

Rank Title Journal Year PubWeight™‹?›
1 MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011 220.97
2 Global cancer statistics. CA Cancer J Clin 2011 185.92
3 Crystal structure refinement with SHELXL. Acta Crystallogr C Struct Chem 2015 158.65
4 Hallmarks of cancer: the next generation. Cell 2011 140.01
5 MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol 2013 112.81
6 Cancer statistics, 2012. CA Cancer J Clin 2012 87.38
7 Cancer statistics, 2013. CA Cancer J Clin 2013 84.72
8 NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012 84.41
9 Fast gapped-read alignment with Bowtie 2. Nat Methods 2012 83.79
10 Cancer statistics, 2014. CA Cancer J Clin 2014 72.81
11 Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011 69.36
12 Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr 2011 67.55
13 Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios. Transl Androl Urol 2016 66.58
14 GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Bioinformatics 2012 65.14
15 An integrated encyclopedia of DNA elements in the human genome. Nature 2012 64.73
16 SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol 2012 62.36
17 An integrated map of genetic variation from 1,092 human genomes. Nature 2012 59.82
18 A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet 2011 59.36
19 Cancer statistics, 2015. CA Cancer J Clin 2015 57.51
20 Fiji: an open-source platform for biological-image analysis. Nat Methods 2012 56.92
21 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 56.72
22 Multiplex genome engineering using CRISPR/Cas systems. Science 2013 55.53
23 Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 2011 53.86
24 Global cancer statistics, 2012. CA Cancer J Clin 2015 53.52
25 Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012 52.99
26 A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 50.94
27 RNA-guided human genome engineering via Cas9. Science 2013 48.29
28 A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012 48.17
29 Integrated genomic analyses of ovarian carcinoma. Nature 2011 47.72
30 Comprehensive molecular portraits of human breast tumours. Nature 2012 47.39
31 Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011 45.46
32 Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012 44.56
33 Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 2014 44.23
34 Integrative genomics viewer. Nat Biotechnol 2011 42.83
35 Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012 41.47
36 Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 2015 40.89
37 Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2014 40.30
38 MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Syst Biol 2012 40.23
39 Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013 39.56
40 REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr 2011 39.32
41 Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011 38.61
42 Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014 36.94
43 Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 2012 35.75
44 Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012 35.24
45 The Cambridge Structural Database. Acta Crystallogr B Struct Sci Cryst Eng Mater 2016 34.37
46 MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol 2013 34.34
47 Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012 34.13
48 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014 34.12
49 SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 2011 33.90
50 SHELXT - integrated space-group and crystal-structure determination. Acta Crystallogr A Found Adv 2015 33.64
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