Evaluation of COPD (Chronic Obstructive Pulmonary Disease) to Longitudinally Identify Predictive Surrogate Endpoints (ECLIPSE)

Clinical Trial ID NCT00292552

PubWeight™ 118.66‹?›

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010 15.07
2 Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med 2011 5.69
3 Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 2012 5.54
4 Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 2010 5.17
5 Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J 2008 4.53
6 Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 2010 3.91
7 Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010 3.44
8 Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med 2010 2.80
9 Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One 2012 2.52
10 Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med 2014 2.28
11 Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort. Thorax 2008 2.25
12 The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study. Lancet Respir Med 2013 2.03
13 Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012 1.99
14 A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet 2011 1.98
15 Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol 2011 1.88
16 Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013 1.79
17 Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012 1.72
18 Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease. Thorax 2012 1.72
19 Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis. Ann Am Thorac Soc 2015 1.72
20 Predictors of objective cough frequency in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013 1.64
21 Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA 2016 1.61
22 Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J 2009 1.56
23 Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med 2012 1.49
24 COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir Res 2011 1.43
25 Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med 2010 1.36
26 Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease. J Am Med Dir Assoc 2011 1.28
27 Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study. Respir Res 2010 1.26
28 Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort. Chest 2015 1.25
29 Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011 1.23
30 Physical activity monitoring in COPD: compliance and associations with clinical characteristics in a multicenter study. Respir Med 2011 1.23
31 Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. Am J Respir Crit Care Med 2014 1.20
32 Genome-wide association study of smoking behaviours in patients with COPD. Thorax 2011 1.18
33 The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol 2011 1.17
34 Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur Respir J 2014 1.17
35 Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One 2011 1.11
36 Respiratory system impedance with impulse oscillometry in healthy and COPD subjects: ECLIPSE baseline results. Respir Med 2011 1.11
37 Factors associated with change in exacerbation frequency in COPD. Respir Res 2013 1.08
38 Elevated airway purines in COPD. Chest 2011 1.07
39 Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD. Mol Biosyst 2012 1.02
40 A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med 2015 1.02
41 An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2014 0.95
42 Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med 2014 0.93
43 Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet 2013 0.92
44 Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease. Thorax 2011 0.91
45 Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2010 0.90
46 Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics 2013 0.89
47 Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort. PLoS One 2014 0.86
48 Vitamin D, vitamin D binding protein, lung function and structure in COPD. Respir Med 2013 0.84
49 One-year change in health status and subsequent outcomes in COPD. Thorax 2015 0.84
50 Genetic association between human chitinases and lung function in COPD. Hum Genet 2011 0.82
51 DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res 2014 0.82
52 Sarcopenic Obesity, Functional Outcomes, and Systemic Inflammation in Patients With Chronic Obstructive Pulmonary Disease. J Am Med Dir Assoc 2016 0.81
53 Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res 2014 0.80
54 A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease. BMC Syst Biol 2014 0.80
55 Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol 2014 0.80
56 The Effect of Statins on Blood Gene Expression in COPD. PLoS One 2015 0.79
57 On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol 2011 0.79
58 Analysis of chloroformate-derivatised amino acids, dipeptides and polyamines by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2013 0.78
59 Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2014 0.78
60 Early response to inhaled bronchodilators and corticosteroids as a predictor of 12-month treatment responder status and COPD exacerbations. Int J Chron Obstruct Pulmon Dis 2016 0.78
61 Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease. BMC Pulm Med 2013 0.77
62 COPD subtypes identified by network-based clustering of blood gene expression. Genomics 2016 0.77
63 Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered 2014 0.77
64 IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2015 0.77
65 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet 2015 0.77
66 High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD - results from the ECLIPSE study. Respir Res 2016 0.76
67 The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease. Nicotine Tob Res 2016 0.76
68 Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort. Genet Epidemiol 2015 0.76
69 Tiotropium and Salmeterol in COPD Patients at Risk of Exacerbations: A Post Hoc Analysis from POET-COPD(®). Adv Ther 2015 0.76
70 DNA methylation profiling in human lung tissue identifies genes associated with COPD. Epigenetics 2016 0.76
71 Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale. Health Qual Life Outcomes 2012 0.76
72 Long-term Course of Depression Trajectories in Patients With COPD: A 3-Year Follow-up Analysis of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Cohort. Chest 2016 0.75
73 SABRE: a method for assessing the stability of gene modules in complex tissues and subject populations. BMC Bioinformatics 2016 0.75
74 Effect of inhaled corticosteroids on blood eosinophil count in steroid-naïve patients with COPD. BMJ Open Respir Res 2016 0.75
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