Study to Prevent Cartilage Damage Following Acute Knee Injury.

Clinical Trial ID NCT00332254

PubWeight™ 63.93‹?›

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. J Orthop Sports Phys Ther 1998 10.08
2 Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med 2000 3.01
3 Inflammation in osteoarthritis. Curr Opin Rheumatol 2011 2.72
4 Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol 2005 2.15
5 Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 1996 1.89
6 In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 1997 1.87
7 Treating inflammation by blocking interleukin-1 in humans. Semin Immunol 2013 1.75
8 Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res Ther 2010 1.61
9 Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. J Rheumatol 2005 1.55
10 In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol 1999 1.52
11 Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proc Natl Acad Sci U S A 2016 1.51
12 Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arthritis Rheum 2013 1.50
13 Early diagnosis to enable early treatment of pre-osteoarthritis. Arthritis Res Ther 2012 1.45
14 Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy 2015 1.42
15 The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases. J Immunol Methods 2004 1.40
16 Inflammatory cytokine profiles associated with chondral damage in the anterior cruciate ligament-deficient knee. Arthroscopy 2005 1.39
17 Cytokines in cartilage injury and repair. Clin Orthop Relat Res 2001 1.38
18 Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am 1993 1.33
19 Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis. Arthritis Rheum 2004 1.32
20 Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthritis Cartilage 2012 1.30
21 Progress in intra-articular therapy. Nat Rev Rheumatol 2013 1.24
22 Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis 2012 1.23
23 [The Knee Injury and Osteoarthritis Outcome Score--a multifunctional questionnaire to measure outcome in knee arthroplasty]. Z Orthop Ihre Grenzgeb 2003 1.21
24 Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum 2011 1.18
25 The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis: Implications for Treatment of Joint Injuries. Cartilage 2013 1.17
26 Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. Arthritis Res Ther 2012 1.16
27 A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med 2011 1.12
28 Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture. J Orthop Res 2015 1.12
29 Biologic agents in osteoarthritis: hopes and disappointments. Nat Rev Rheumatol 2013 1.07
30 Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol Suppl 1995 1.06
31 Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. Arthritis Res Ther 2014 1.04
32 Development and validation of health-related quality of life measures for the knee. Clin Orthop Relat Res 2002 1.00
33 Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury. Osteoarthritis Cartilage 2013 0.99
34 Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway. Arthritis Res Ther 2012 0.97
35 Chondroscopy: a new method for scoring chondropathy. Semin Arthritis Rheum 1993 0.97
36 Serum CTXii Correlates With Articular Cartilage Degeneration After Anterior Cruciate Ligament Transection or Arthrotomy Followed by Standardized Exercise. Sports Health 2012 0.94
37 The reliability and validity of knee-specific and general health instruments in assessing acute patellar dislocation outcomes. Am J Sports Med 2003 0.92
38 Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold. Osteoarthritis Cartilage 2013 0.92
39 Osteoarthritis joint pain: the cytokine connection. Cytokine 2014 0.92
40 The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive. J Rheumatol 2015 0.92
41 Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. Eur Cell Mater 2015 0.92
42 Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA. Osteoarthritis Cartilage 2011 0.92
43 Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther 2012 0.89
44 Inflammation in joint injury and post-traumatic osteoarthritis. Osteoarthritis Cartilage 2015 0.87
45 Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity. J Biol Chem 2012 0.87
46 AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Ann Rheum Dis 2013 0.85
47 Disposition of human recombinant lubricin in naive rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration. AAPS J 2012 0.85
48 In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity. J Biomech 2015 0.85
49 Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Arthritis Res Ther 2011 0.84
50 CD8+ T cell-induced expression of tissue inhibitor of metalloproteinses-1 exacerbated osteoarthritis. Int J Mol Sci 2013 0.84
51 Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes. Biosci Rep 2015 0.83
52 Injurious Loading of Articular Cartilage Compromises Chondrocyte Respiratory Function. Arthritis Rheumatol 2016 0.83
53 Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis. Arthritis Rheumatol 2014 0.83
54 Effects over time of two platelet gel supernatants on growth factor, cytokine and hyaluronan concentrations in normal synovial membrane explants challenged with lipopolysaccharide. BMC Musculoskelet Disord 2015 0.82
55 An expanding role for interleukin-1 blockade from gout to cancer. Mol Med 2014 0.82
56 Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid. BMC Musculoskelet Disord 2012 0.81
57 Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis. Osteoarthritis Cartilage 2014 0.81
58 Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis. Osteoarthritis Cartilage 2015 0.81
59 A new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum. Orthop Rev (Pavia) 2013 0.80
60 Magnetic Capture of a Molecular Biomarker from Synovial Fluid in a Rat Model of Knee Osteoarthritis. Ann Biomed Eng 2015 0.80
61 Posttraumatic knee osteoarthritis following anterior cruciate ligament injury: Potential biochemical mediators of degenerative alteration and specific biochemical markers. Biomed Rep 2014 0.79
62 Early knee osteoarthritis. RMD Open 2015 0.79
63 A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers. J R Soc Interface 2014 0.78
64 Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model. J Inflamm (Lond) 2014 0.78
65 Effects of low and high dose intraarticular tiludronate on synovial fluid and clinical variables in healthy horses-a preliminary investigation. PeerJ 2014 0.78
66 Differential response of chondrocytes and chondrogenic-induced mesenchymal stem cells to C1-OH tributanoylated N-acetylhexosamines. PLoS One 2013 0.78
67 Effect of Matching or Overconstraining Knee Laxity During Anterior Cruciate Ligament Reconstruction on Knee Osteoarthritis and Clinical Outcomes: A Randomized Controlled Trial With 84-Month Follow-up. Am J Sports Med 2016 0.77
68 scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy. Gene Ther 2015 0.77
69 Xanthine oxidase injurious response in acute joint injury. Clin Chim Acta 2015 0.77
70 Early intra-articular complement activation in ankle fractures. Biomed Res Int 2014 0.77
71 Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes. Arthritis Rheumatol 2016 0.77
72 Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol 2016 0.76
73 Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles. Int J Mol Sci 2016 0.76
74 Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation. RMD Open 2016 0.76
75 Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro. Sci Rep 2016 0.76
76 Intraarticular Matrix Metalloproteinases and Aggrecan Degradation Are Elevated After Articular Fracture. Clin Orthop Relat Res 2015 0.75
77 Synthesis of self-assembled IL-1Ra-presenting nanoparticles for the treatment of osteoarthritis. J Biomed Mater Res A 2015 0.75
78 A new treatment for knee osteoarthritis: Clinical evidence for the efficacy of Arthrokinex™ autologous conditioned serum. J Orthop 2016 0.75
79 OsteoRheumatology: a new discipline? RMD Open 2015 0.75
80 Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury. BMC Musculoskelet Disord 2016 0.75
81 MicroRNA-33 suppresses CCL2 expression in chondrocytes. Biosci Rep 2016 0.75
82 Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect. J Exp Orthop 2016 0.75
83 Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes. Mol Ther Methods Clin Dev 2016 0.75
84 Prospective Clinical Trial for Septic Arthritis: Cartilage Degradation and Inflammation Are Associated with Upregulation of Cartilage Metabolites. Mediators Inflamm 2016 0.75
85 Serum xylosyltransferase 1 level increases during early posttraumatic osteoarthritis in mice with high bone forming potential. Bone 2011 0.75
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