Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease

Clinical Trial ID NCT00492531

PubWeight™ 18.33‹?›

🔗 Visit the ClinicalTrials.gov page for NCT00492531

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation 2011 2.01
2 The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica 2012 1.72
3 Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood 2011 1.64
4 Pulmonary hypertension in sickle cell disease. Am J Cardiol 1994 1.44
5 Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction. Front Genet 2012 1.19
6 Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. Blood 2012 1.12
7 Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates. Am J Hematol 2012 1.10
8 A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS One 2012 1.04
9 Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. JAMA 2008 1.02
10 Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One 2014 1.00
11 Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models. Circ Cardiovasc Genet 2014 0.95
12 Systemic fat embolism and pulmonary hypertension in sickle cell disease. Hematol Oncol Clin North Am 1996 0.94
13 Pharmacotherapy in sickle cell disease--state of the art and future prospects. Br J Haematol 2009 0.92
14 Genetic determinants of haemolysis in sickle cell anaemia. Br J Haematol 2013 0.89
15 Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I. Hematology Am Soc Hematol Educ Program 2008 0.84
16 Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease. PLoS One 2014 0.81
17 Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion 2016 0.77
18 Pulmonary hypertension and sickle hemoglobinopathy. Chest 1990 0.75
19 The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol 2014 0.75
20 Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC. Clin J Am Soc Nephrol 2015 0.75
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