| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.
|
JAMA
|
2002
|
80.37
|
|
2
|
Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group.
|
N Engl J Med
|
2000
|
41.18
|
|
3
|
Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings.
|
MMWR Recomm Rep
|
2006
|
37.28
|
|
4
|
Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus.
|
N Engl J Med
|
2007
|
7.79
|
|
5
|
Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1.
|
Ann Intern Med
|
2007
|
7.14
|
|
6
|
Sexual transmission of HIV.
|
N Engl J Med
|
1997
|
6.84
|
|
7
|
Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa.
|
AIDS Res Hum Retroviruses
|
2001
|
6.00
|
|
8
|
Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease.
|
N Engl J Med
|
1982
|
5.65
|
|
9
|
Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study.
|
AIDS
|
2000
|
4.91
|
|
10
|
Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model.
|
AIDS
|
2001
|
4.76
|
|
11
|
Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team.
|
N Engl J Med
|
1999
|
4.12
|
|
12
|
Reduced lopinavir exposure during pregnancy.
|
AIDS
|
2006
|
3.98
|
|
13
|
Probability of female-to-male transmission of HIV-1 in Thailand.
|
Lancet
|
1994
|
3.66
|
|
14
|
Effect of antiviral treatment on the shedding of HIV-1 in semen.
|
AIDS
|
1997
|
3.42
|
|
15
|
Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis.
|
J Infect Dis
|
2004
|
3.17
|
|
16
|
The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Italian Study Group on HIV Heterosexual Transmission.
|
Epidemiology
|
1994
|
3.05
|
|
17
|
Recent observations on HIV type-1 infection in the genital tract of men and women.
|
AIDS
|
2003
|
2.97
|
|
18
|
Production and actions of estrogens.
|
N Engl J Med
|
2002
|
2.66
|
|
19
|
Sexual transmission of HIV: infectiousness and prevention.
|
AIDS
|
1999
|
2.59
|
|
20
|
Risk factors for HIV infection among young adult men in northern Thailand.
|
JAMA
|
1993
|
2.53
|
|
21
|
Defining menopause status: creation of a new definition to identify the early changes of the menopausal transition.
|
Menopause
|
2005
|
2.50
|
|
22
|
Male viral load and heterosexual transmission of HIV-1 subtype E in northern Thailand.
|
J Acquir Immune Defic Syndr
|
2002
|
2.48
|
|
23
|
Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in the infected partner.
|
J Acquir Immune Defic Syndr
|
1999
|
2.36
|
|
24
|
Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry.
|
Biomed Chromatogr
|
2007
|
2.17
|
|
25
|
Treatment of cervicitis is associated with decreased cervical shedding of HIV-1.
|
AIDS
|
2001
|
1.88
|
|
26
|
Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2006
|
1.78
|
|
27
|
Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism.
|
Br J Clin Pharmacol
|
2006
|
1.66
|
|
28
|
Hormonal changes in the menopause transition.
|
Recent Prog Horm Res
|
2002
|
1.62
|
|
29
|
Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations.
|
Clin Pharmacokinet
|
1997
|
1.61
|
|
30
|
A longitudinal study of urinary creatinine and creatinine clearance in normal subjects. Race, sex, and age differences.
|
Am J Hypertens
|
1988
|
1.60
|
|
31
|
Gender difference in HIV RNA levels: a meta-analysis of published studies.
|
J Acquir Immune Defic Syndr
|
2002
|
1.59
|
|
32
|
Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trial.
|
AIDS
|
2006
|
1.58
|
|
33
|
Concentration-controlled compared with conventional antiretroviral therapy for HIV infection.
|
AIDS
|
2002
|
1.58
|
|
34
|
Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities.
|
Clin Pharmacol Ther
|
1991
|
1.55
|
|
35
|
Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team.
|
AIDS
|
2000
|
1.54
|
|
36
|
Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities.
|
Clin Pharmacol Ther
|
1992
|
1.51
|
|
37
|
Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals.
|
AIDS
|
2003
|
1.51
|
|
38
|
The effects of antiretroviral therapy on HIV-1 RNA loads in seminal plasma in HIV-positive patients with and without urethritis.
|
AIDS
|
2002
|
1.50
|
|
39
|
Induction of CYP2D6 in pregnancy.
|
Clin Pharmacol Ther
|
1997
|
1.48
|
|
40
|
A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding.
|
AIDS
|
2001
|
1.45
|
|
41
|
Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected women.
|
J Acquir Immune Defic Syndr
|
2004
|
1.45
|
|
42
|
Influence of age on the pharmacokinetics of alfentanil. Gender dependence.
|
Clin Pharmacokinet
|
1990
|
1.43
|
|
43
|
Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load.
|
AIDS Res Hum Retroviruses
|
2006
|
1.37
|
|
44
|
Sexual transmission during the incubation period of primary HIV infection.
|
JAMA
|
2001
|
1.37
|
|
45
|
Heterosexual HIV-1 transmission and viral load in hemophilic patients.
|
J Acquir Immune Defic Syndr Hum Retrovirol
|
1998
|
1.36
|
|
46
|
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance.
|
Cancer Res
|
2006
|
1.35
|
|
47
|
Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.
|
J Infect Dis
|
1999
|
1.32
|
|
48
|
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359.
|
J Infect Dis
|
2004
|
1.30
|
|
49
|
Pharmacokinetics of saquinavir-SGC in HIV-infected pregnant women.
|
HIV Clin Trials
|
2001
|
1.30
|
|
50
|
Menopause transition: Annual changes in serum hormonal patterns over the menstrual cycle in women during a nine-year period prior to menopause.
|
J Clin Endocrinol Metab
|
2004
|
1.29
|
|
51
|
Bacterial vaginosis: risk factors among Kenyan women and their male partners.
|
Sex Transm Dis
|
2006
|
1.28
|
|
52
|
Clinical pharmacokinetics of cerivastatin.
|
Clin Pharmacokinet
|
2000
|
1.21
|
|
53
|
Concentration-controlled zidovudine therapy.
|
Clin Pharmacol Ther
|
1998
|
1.20
|
|
54
|
Age-related changes in protein binding of drugs: implications for therapy.
|
Clin Pharmacokinet
|
2000
|
1.20
|
|
55
|
The disposition of caffeine during and after pregnancy.
|
Semin Perinatol
|
1981
|
1.19
|
|
56
|
Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography.
|
Clin Pharmacol Ther
|
2006
|
1.18
|
|
57
|
Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.
|
J Pharmacol Exp Ther
|
1995
|
1.17
|
|
58
|
Sexual activity and satisfaction among very old adults: results from a community-dwelling Medicare population survey.
|
Gerontologist
|
1997
|
1.17
|
|
59
|
Gender differences in pharmacokinetics.
|
Eur J Drug Metab Pharmacokinet
|
1996
|
1.14
|
|
60
|
Bacterial vaginosis and host immunity.
|
Curr HIV/AIDS Rep
|
2007
|
1.14
|
|
61
|
Effect of pregnancy on the pharmacokinetics of caffeine.
|
Eur J Clin Pharmacol
|
1981
|
1.12
|
|
62
|
Sexual behavior of older women: results of a random-digit-dialing survey of 2,000 women in the United States.
|
Sex Transm Dis
|
2003
|
1.11
|
|
63
|
Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant women.
|
AIDS
|
2003
|
1.08
|
|
64
|
Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC-MS/MS.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2006
|
1.08
|
|
65
|
Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus.
|
Antimicrob Agents Chemother
|
1994
|
1.07
|
|
66
|
CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences.
|
Eur J Clin Pharmacol
|
1999
|
1.06
|
|
67
|
Intracellular carbovir triphosphate levels in patients taking abacavir once a day.
|
AIDS
|
2002
|
1.05
|
|
68
|
The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers.
|
Eur J Clin Pharmacol
|
2001
|
1.04
|
|
69
|
Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis.
|
AIDS
|
1998
|
1.03
|
|
70
|
Longitudinal assessment of HIV-1 and HSV-2 shedding in the genital tract of West African women.
|
J Acquir Immune Defic Syndr
|
2005
|
1.02
|
|
71
|
Sex-related differences in the pharmacokinetics of once-daily saquinavir soft-gelatin capsules boosted with low-dose ritonavir in patients infected with human immunodeficiency virus type 1.
|
Pharmacotherapy
|
2004
|
1.00
|
|
72
|
Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping.
|
Clin Pharmacol Ther
|
1998
|
0.99
|
|
73
|
Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype.
|
Psychopharmacology (Berl)
|
1996
|
0.96
|
|
74
|
Pharmacokinetic variability caused by gender: do women have higher indinavir exposure than men?
|
J Acquir Immune Defic Syndr
|
2002
|
0.95
|
|
75
|
Hormonal regulation of lipoprotein(a) levels: effects of estrogen replacement therapy on lipoprotein(a) and acute phase reactants in postmenopausal women.
|
Arterioscler Thromb Vasc Biol
|
1997
|
0.94
|
|
76
|
Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients.
|
J Antimicrob Chemother
|
2003
|
0.93
|
|
77
|
Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.
|
Br J Clin Pharmacol
|
1984
|
0.92
|
|
78
|
Quantitation of intracellular triphosphate of emtricitabine in peripheral blood mononuclear cells from human immunodeficiency virus-infected patients.
|
Antimicrob Agents Chemother
|
1999
|
0.92
|
|
79
|
Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans.
|
J Clin Pharmacol
|
2000
|
0.91
|
|
80
|
Imipramine and desipramine disposition in the elderly.
|
J Pharmacol Exp Ther
|
1985
|
0.90
|
|
81
|
Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population.
|
Br J Clin Pharmacol
|
2000
|
0.90
|
|
82
|
No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects.
|
Clin Pharmacol Ther
|
2000
|
0.89
|
|
83
|
Race and sex influence clearance of nifedipine: results of a population study.
|
Clin Pharmacol Ther
|
2000
|
0.89
|
|
84
|
Estrogen receptor alpha regulates insulin sensitivity through IRS-1 tyrosine phosphorylation in mature 3T3-L1 adipocytes.
|
Endocr J
|
2006
|
0.88
|
|
85
|
Acute consequences of the menopausal transition: the rise of common menopausal symptoms.
|
Endocrinol Metab Clin North Am
|
2004
|
0.88
|
|
86
|
The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics.
|
Clin Pharmacol Ther
|
1996
|
0.87
|
|
87
|
Sexual activity and risk-taking in later life.
|
Health Soc Care Community
|
2001
|
0.87
|
|
88
|
Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal.
|
Eur J Clin Pharmacol
|
1990
|
0.86
|
|
89
|
Menstrual cycle variability in midazolam pharmacokinetics.
|
J Clin Pharmacol
|
1999
|
0.85
|
|
90
|
Metabolic effects and pharmacokinetics of a growth hormone pulse in healthy adults: relation to age, sex, and body composition.
|
J Clin Endocrinol Metab
|
1997
|
0.85
|
|
91
|
Faster clearance of sustained release verapamil in men versus women: continuing observations on sex-specific differences after oral administration of verapamil.
|
Clin Pharmacol Ther
|
2000
|
0.83
|
|
92
|
Pharmacology of cancer chemotherapy in the older person.
|
Clin Geriatr Med
|
1997
|
0.81
|
|
93
|
Age- and gender-related differences in carbohydrate concentrations of alpha1-acid glycoprotein variants and the effects of glycoforms on their drug-binding capacities.
|
Eur J Clin Pharmacol
|
2002
|
0.81
|
|
94
|
Cancer pharmacology in the elderly.
|
Semin Oncol
|
1993
|
0.80
|
|
95
|
The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers.
|
Br J Clin Pharmacol
|
1994
|
0.78
|
|
96
|
Changes in 40 serum proteins of post-menopausal women.
|
Maturitas
|
1991
|
0.78
|
|
97
|
Tyrosine kinase activity of nerve growth factor and estrogen in embryonic septal neurons cultured from the rat.
|
Neurochem Res
|
2002
|
0.78
|
|
98
|
The ageing female reproductive axis I.
|
Novartis Found Symp
|
2002
|
0.77
|
|
99
|
Sex, age and alfentanil pharmacokinetics.
|
Clin Pharmacokinet
|
1991
|
0.76
|
|
100
|
Hormonal effects on tirilazad clearance in women: assessment of the role of CYP3A.
|
J Clin Pharmacol
|
1999
|
0.76
|