Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment (KEPAL)

Clinical Trial ID NCT01326325

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Molecular and cellular mechanisms of general anaesthesia. Nature 1994 6.94
2 PHARMACOLOGIC EFFECTS OF CI-581, A NEW DISSOCIATIVE ANESTHETIC, IN MAN. Clin Pharmacol Ther 1965 2.56
3 Low-dose ketamine in the management of opioid nonresponsive terminal cancer pain. J Pain Symptom Manage 1999 1.93
4 New clinical-practice guidelines for the management of pain in patients with cancer. N Engl J Med 1994 1.70
5 Opioid substitution to reduce adverse effects in cancer pain management. Med J Aust 1999 1.48
6 Ketamine as an adjunct to morphine in the treatment of pain. Pain 1995 1.42
7 [Cancer pain: beneficial effect of ketamine addition to spinal administration of morphine-clonidine-lidocaine mixture]. Ann Fr Anesth Reanim 1996 1.41
8 Transporting patients with overwhelming pain. Anaesthesia 1994 1.39
9 Ketamine-fentanyl-midazolam infusion for the control of symptoms in terminal life care. Am J Hosp Palliat Care 2001 1.39
10 Is the site of action of ketamine anesthesia the N-methyl-D-aspartate receptor? Anesthesiology 1990 1.25
11 Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study. J Pain Symptom Manage 2000 1.12
12 Continuous subcutaneous injection of ketamine for cancer pain. Can J Anaesth 1990 1.10
13 Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 1981 1.09
14 Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst Rev 2003 1.09
15 Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management. Anesthesiology 1999 1.08
16 Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. Can J Anaesth 1996 1.05
17 Low-dose subcutaneous ketamine infusion and morphine tolerance. Pain 1999 1.00
18 NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain 1996 0.95
19 Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 1994 0.94
20 Ketamine attenuates and reverses morphine tolerance in rodents. Anesthesiology 1996 0.91
21 The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain 1996 0.91
22 Effective treatment of severe cancer pain of the head using low-dose ketamine in an opioid-tolerant patient. J Pain Symptom Manage 1995 0.90
23 Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. Neurosurgery 1995 0.90
24 Oral ketamine as an adjuvant to oral morphine for neuropathic pain in cancer patients. J Pain Symptom Manage 2002 0.84
25 Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization. Pain 1995 0.84
26 Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo. Clin Neuropharmacol 1995 0.82
27 "Burst" ketamine for refractory cancer pain: an open-label audit of 39 patients. J Pain Symptom Manage 2001 0.81
28 Relief of glossopharyngeal neuralgia by ketamine-induced N-methyl-aspartate receptor blockade. Neurosurgery 1997 0.81
29 Adjuvant ketamine analgesia for the management of cancer pain. Ann Pharmacother 2002 0.81
30 Summary version of the Standards, Options and Recommendations for the use of analgesia for the treatment of nociceptive pain in adults with cancer (update 2002). Br J Cancer 2003 0.79
31 [Standards, options and recommendations for the use of medical analgesics for the treatment of pain arising from excess nociception in adults with cancer (update 2002): opioid analgesics with the exception of morphine by mouth and the rotation]. Bull Cancer 2003 0.77
32 Ketamine for cancer pain. J Pain Symptom Manage 2000 0.77
33 [Ketamine infusion for control of pain in patients with advanced cancer]. Masui 1990 0.75
34 Pain management: physiopathology, future research and endpoints. Support Care Cancer 1993 0.75
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