First in Man Study Investigating the Biodistribution, the Safety and Optimal Recommended Dose of a New Radiolabelled Monoclonal Antibody Targeting Frizzled Homolog 10 (SYNFRIZZ)

Clinical Trial ID NCT01469975

PubWeight™ 8.28‹?›

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cancer statistics, 2010. CA Cancer J Clin 2010 103.28
2 Molecular characterisation of soft tissue tumours: a gene expression study. Lancet 2002 7.05
3 Soft-tissue sarcomas in adults. N Engl J Med 2005 5.97
4 Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration. Lancet 1997 4.45
5 The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 2006 4.14
6 Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol 2009 3.41
7 Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J Clin Oncol 2005 2.39
8 Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol 2001 2.29
9 Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. J Clin Oncol 2004 2.27
10 Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity. J Clin Oncol 2000 2.22
11 Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol 2015 2.02
12 Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J Clin Oncol 2003 1.94
13 Fusions of the SYT and SSX genes in synovial sarcoma. Oncogene 2001 1.59
14 Feasibility of 90Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres. Eur J Nucl Med Mol Imaging 2010 1.51
15 Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma. Clin Cancer Res 1996 1.47
16 Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Am J Pathol 2002 1.46
17 Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG). Eur J Cancer 2010 1.43
18 A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma. Blood 2005 1.41
19 Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res 2002 1.37
20 A phase II study of gefitinib for patients with advanced HER-1 expressing synovial sarcoma refractory to doxorubicin-containing regimens. Oncologist 2008 1.31
21 Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J Clin Oncol 1996 1.30
22 Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch. Cell Cycle 2012 1.26
23 Molecular classification of soft tissue sarcomas and its clinical applications. Int J Clin Exp Pathol 2010 1.15
24 The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther 2010 1.09
25 Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging? Eur J Nucl Med Mol Imaging 2011 1.09
26 Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling. Br J Cancer 2003 1.08
27 Radiolabeled DOTATOC in patients with advanced paraganglioma and pheochromocytoma. Q J Nucl Med Mol Imaging 2008 1.08
28 90Y Bremsstrahlung imaging for absorbed-dose assessment in high-dose radioimmunotherapy. J Nucl Med 2010 1.03
29 Radioimmunotherapy of non-Hodgkin lymphomas. Blood 2002 1.03
30 Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Oncogene 2005 1.00
31 Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting. Sarcoma 2012 0.99
32 Fast simulation of yttrium-90 bremsstrahlung photons with GATE. Med Phys 2010 0.96
33 Cancer stem cell plasticity and tumor hierarchy. World J Stem Cells 2015 0.96
34 Pharmacokinetics of therapeutic monoclonal antibodies used in oncology. Anticancer Res 2005 0.96
35 Advancing role of radiolabeled antibodies in the therapy of cancer. Cancer Immunol Immunother 2003 0.95
36 Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model. J Nucl Med 2006 0.95
37 Biodistribution and radioimmunotherapy of human breast cancer xenografts with radiometal-labeled DOTA conjugated anti-HER2/neu antibody 4D5. Bioconjug Chem 2000 0.94
38 The rationale for targeted therapies in medulloblastoma. Neuro Oncol 2013 0.92
39 High-dose therapy with 90Yttrium-labeled monoclonal antibody CC49: a phase I trial. Clin Cancer Res 2000 0.91
40 Targeted radiotherapy for small cell lung cancer using 90Yttrium-DOTATOC, an Yttrium-labelled somatostatin analogue: a pilot trial. Lung Cancer 2004 0.91
41 [Incidence rate, epidemiology of sarcoma and molecular biology. Preliminary results from EMS study in the Rhône-Alpes region]. Bull Cancer 2010 0.89
42 Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. Cancer Sci 2008 0.88
43 MR imaging of soft tissue tumors and tumor-like lesions. Pediatr Radiol 2003 0.86
44 Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy. Cancer Discov 2015 0.86
45 Predicting hematologic toxicity in patients undergoing radioimmunotherapy with 90Y-ibritumomab tiuxetan or 131I-tositumomab. J Nucl Med 2010 0.86
46 Multicenter ProstaScint imaging findings in 2154 patients with prostate cancer. The ProstaScint Imaging Centers. Urology 2000 0.85
47 Radioimmunotherapy of non-Hodgkin's lymphoma: clinical development of the Zevalin regimen. Biotechnol Annu Rev 2004 0.85
48 Radioimmunotherapy of solid tumors targeting a cell-surface protein, FZD10: therapeutic efficacy largely depends on radiosensitivity. Ann Nucl Med 2009 0.83
49 Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. Biochem Biophys Res Commun 1999 0.83
50 Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3. Clin Cancer Res 2000 0.80
51 Dosimetry-based therapy in metastatic breast cancer patients using 90Y monoclonal antibody 170H.82 with autologous stem cell support and cyclosporin A. Clin Cancer Res 1999 0.78
52 On clonogenic tumour cells and metastasis-forming cells. Nat Rev Cancer 2008 0.77
53 Block co-polymeric magnetic resonance contrast agents. Invest Radiol 1994 0.77
54 Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. FASEB J 2016 0.77
55 Translational and clinical implications of the genetic landscape of prostate cancer. Nat Rev Clin Oncol 2016 0.76
56 Radioimmunodiagnosis and therapy. Cancer Treat Rev 2000 0.75
57 Clinical experience with radiolabelled monoclonal antibodies in the detection of colorectal and ovarian carcinoma recurrence and review of the literature. Nucl Med Commun 1999 0.75
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