PubRank

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Clinical Trial ID NCT01576666

PubWeight™ 20.76‹?›

🔗 Visit the ClinicalTrials.gov page for NCT01576666

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med 2013 2.55
2 Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov 2014 2.55
3 Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol 2015 2.02
4 Mechanisms regulating glioma invasion. Cancer Lett 2015 1.19
5 Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Nat Med 2013 1.19
6 PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma. Oncotarget 2016 1.02
7 The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy. Breast Cancer Res 2013 1.01
8 Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. Oncotarget 2015 0.97
9 Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res 2015 0.96
10 The rationale for targeted therapies in medulloblastoma. Neuro Oncol 2013 0.92
11 Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis 2015 0.90
12 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened. Oncotarget 2015 0.89
13 Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. Expert Rev Mol Med 2015 0.87
14 Targeted treatment for sonic hedgehog-dependent medulloblastoma. Neuro Oncol 2014 0.83
15 The hedgehog pathway in triple-negative breast cancer. Cancer Med 2016 0.80
16 Medulloblastoma development: tumor biology informs treatment decisions. CNS Oncol 2015 0.78
17 An integrated network platform for contextual prioritization of drugs and pathways. Mol Biosyst 2015 0.77
18 Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer. Pancreas 2016 0.75
19 Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review. World J Gastrointest Pathophysiol 2016 0.75
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