The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects (GuaKet)

Clinical Trial ID NCT01600885

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971 86.03
2 Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry 2000 6.91
3 Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med 2006 4.00
4 Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 2007 3.60
5 Magical ideation as an indicator of schizotypy. J Consult Clin Psychol 1983 2.65
6 Body-image aberration in Schizophrenia. J Abnorm Psychol 1978 2.29
7 Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice. J Neurosci 2007 1.94
8 An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1995 1.81
9 Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence. Biol Psychiatry 2008 1.76
10 Sustained mnemonic response in the human middle frontal gyrus during on-line storage of spatial memoranda. J Cogn Neurosci 2002 1.63
11 Guanfacine treatment of cognitive impairment in schizophrenia. Neuropsychopharmacology 2001 1.61
12 Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Arch Gen Psychiatry 2005 1.52
13 DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J Comp Neurol 2006 1.42
14 Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology 1999 1.23
15 Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys. Biol Psychiatry 2005 1.05
16 Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2007 1.04
17 Dendritic spine density in schizophrenia and depression. Arch Gen Psychiatry 2001 1.00
18 Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proc Natl Acad Sci U S A 2006 0.95
19 The effects of guanfacine on context processing abnormalities in schizotypal personality disorder. Biol Psychiatry 2006 0.95
20 Imidazoline antihypertensive drugs: a critical review on their mechanism of action. Pharmacol Ther 2002 0.94
21 How has DISC1 enabled drug discovery? Mol Cell Neurosci 2007 0.94
22 Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine. Neurobiol Aging 1994 0.91
23 Adrenergic alpha2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type. J Neural Transm (Vienna) 2008 0.91
24 The effects of an alpha-2 adrenergic agonist, guanfacine, on rCBF in human cortex in normal controls and subjects with focal epilepsy. Neuropsychopharmacology 2000 0.83
25 Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology (Berl) 2005 0.82
26 Neuropharmacologic and behavioral actions of clonidine: interactions with central neurotransmitters. Int Rev Neurobiol 1992 0.81
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