Verapamil as Therapy for Children and Young Adults With Dravet Syndrome

Clinical Trial ID NCT01607073

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol 2006 2.43
2 Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations. Clin Pharmacol Ther 1998 2.09
3 Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. Lamictal Lennox-Gastaut Study Group. N Engl J Med 1997 1.99
4 Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet 2000 1.76
5 Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy. Epilepsy Res 2009 1.59
6 Clobazam: a review of its pharmacological properties and therapeutic use in anxiety. Drugs 1980 1.22
7 Calcium channel blockers: pharmacology and place in therapy of pediatric hypertension. Pediatr Nephrol 2000 1.15
8 Dose of midazolam should be reduced during diltiazem and verapamil treatments. Br J Clin Pharmacol 1994 1.11
9 Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies. Epilepsy Res 2009 1.07
10 Prolongation of verapamil elimination kinetics during chronic oral administration. Am Heart J 1982 1.07
11 Clobazam kinetics in the elderly. Br J Clin Pharmacol 1981 1.04
12 Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil. Biochem Pharmacol 1985 1.02
13 Therapeutic drug monitoring of old and newer anti-epileptic drugs. Clin Chem Lab Med 2004 1.02
14 Electrical and autonomic cardiac function in patients with Dravet syndrome. Epilepsia 2011 1.01
15 Dravet syndrome and parent associations: the IDEA League experience with comorbid conditions, mortality, management, adaptation, and grief. Epilepsia 2011 1.00
16 Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients. Br J Clin Pharmacol 1984 0.98
17 Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos 2004 0.96
18 Prognostic implications of autonomic function assessed by analyses of catecholamines and heart rate variability in stable angina pectoris. Heart 2002 0.90
19 In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug Metab Dispos 2006 0.90
20 The effect of coadministration of verapamil on the pharmacokinetics and metabolism of quinidine. Clin Pharmacol Ther 1987 0.83
21 The effects of dihydropyridine and phenylalkylamine calcium antagonist classes on autonomic function in hypertension: the VAMPHYRE study. Am J Hypertens 2001 0.83
22 In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos 2004 0.83
23 Verapamil: an effective calcium blocking agent for pediatric patients. Pediatrics 1983 0.82
24 Effect of calcium channel blockers on theophylline disposition. Clin Pharmacol Ther 1988 0.82
25 Power spectrum analysis of heart rate variability in children with epilepsy. Childs Nerv Syst 2001 0.82
26 Stiripentol open study in Japanese patients with Dravet syndrome. Epilepsia 2009 0.81
27 Heart rate variability during sleep in children with partial epilepsy. J Sleep Res 2002 0.81
28 Effect of felbamate on clobazam and its metabolite kinetics in patients with epilepsy. Ther Drug Monit 1999 0.80
29 Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans. J Pharmacol Exp Ther 1988 0.80
30 Childhood-onset cluster headache. Pediatr Neurol 2002 0.80
31 Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone. Clin Pharmacol Ther 1998 0.79
32 Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers. Clin Pharmacol Ther 2000 0.79
33 Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids. Am J Health Syst Pharm 1996 0.78
34 The effect of three different oral doses of verapamil on the disposition of theophylline. Eur J Clin Pharmacol 1992 0.76
35 Comparison of verapamil versus felodipine on heart rate variability in hypertensive patients. J Hypertens 1999 0.75
36 Safety and efficacy of short- and long-term verapamil therapy in children with tachycardia. Am J Cardiol 1981 0.75
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