Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness (ORBEX)

Clinical Trial ID NCT02148796

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007 7.10
2 Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 2004 6.93
3 Measuring quality of life in children with asthma. Qual Life Res 1996 6.76
4 Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011 6.38
5 Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008 6.35
6 Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 2006 6.10
7 Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000 5.24
8 A community-based study of the epidemiology of asthma. Incidence rates, 1964-1983. Am Rev Respir Dis 1992 5.22
9 Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001 4.70
10 Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007 4.54
11 An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007 4.10
12 Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med 2011 4.09
13 A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000 3.49
14 Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 2010 2.53
15 The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol 2010 2.35
16 Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan. Pediatrics 2008 2.29
17 Inadequate therapy for asthma among children in the United States. Pediatrics 2000 2.17
18 Design and methods of the National Cooperative Inner-City Asthma Study. Pediatr Pulmonol 1997 1.95
19 The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network. Control Clin Trials 2004 1.79
20 Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev 2013 1.77
21 High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax 2006 1.72
22 Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ 2013 1.67
23 Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2010 1.55
24 Augmented lung inflammation protects against influenza A pneumonia. PLoS One 2009 1.47
25 Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol 2009 1.36
26 MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy 2011 1.22
27 Do early-life viral infections cause asthma? J Allergy Clin Immunol 2010 1.16
28 Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire. Health Qual Life Outcomes 2003 1.16
29 Environmental determinants of and impact on childhood asthma by the bacterial community in household dust. Appl Environ Microbiol 2010 1.14
30 The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol 2010 1.14
31 Age and risks of FDA-approved long-acting β₂-adrenergic receptor agonists. Pediatrics 2011 1.13
32 Development and validation of the Composite Asthma Severity Index--an outcome measure for use in children and adolescents. J Allergy Clin Immunol 2012 1.12
33 The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol 2010 1.03
34 The Canadian asthma primary prevention study: outcomes at 2 years of age. J Allergy Clin Immunol 2004 1.02
35 The role of rhinovirus infections in the development of early childhood asthma. Curr Opin Allergy Clin Immunol 2010 0.99
36 Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control. Mucosal Immunol 2010 0.98
37 Stimulation of nonspecific immunity to reduce the risk of recurrent infections in children attending day-care centers. The Epicrèche Research Group. Pediatr Infect Dis J 1993 0.97
38 Microbial manipulation of immune function for asthma prevention: inferences from clinical trials. Proc Am Thorac Soc 2007 0.97
39 Drug development strategies for asthma: in search of a new paradigm. Nat Immunol 2004 0.95
40 OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr 2010 0.93
41 New insights into the natural history of asthma: primary prevention on the horizon. J Allergy Clin Immunol 2011 0.91
42 Respiratory viral infections in children with asthma: do they matter and can we prevent them? BMC Pediatr 2012 0.89
43 The connection between early life wheezing and subsequent asthma: The viral march. Allergol Immunopathol (Madr) 2009 0.88
44 Asthma management guidelines: updates, advances, and new options. J Manag Care Pharm 2007 0.88
45 Immunostimulants for preventing respiratory tract infection in children. Cochrane Database Syst Rev 2006 0.87
46 Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS One 2013 0.82
47 T regulatory cells in childhood asthma. Trends Immunol 2011 0.81
48 Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med 2009 0.81
49 Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance. Am J Physiol Lung Cell Mol Physiol 2009 0.78
50 What is new in the prevention of atopy and asthma? Curr Opin Allergy Clin Immunol 2013 0.76
51 Enhanced Mucosal Antibody Production and Protection against Respiratory Infections Following an Orally Administered Bacterial Extract. Front Med (Lausanne) 2014 0.76
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