PTC596 in Patients With Advanced Solid Tumors

Clinical Trial ID NCT02404480

PubWeight™ 1.63‹?›

🔗 Visit the ClinicalTrials.gov page for NCT02404480

Top papers

Rank Title Journal Year PubWeight™‹?›
1 New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009 77.71
2 Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 2010 14.79
3 Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003 14.35
4 Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006 11.48
5 Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 2003 11.23
6 Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005 6.29
7 Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 2005 5.90
8 American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol 2006 4.97
9 Self-renewal as a therapeutic target in human colorectal cancer. Nat Med 2013 4.20
10 Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 2004 3.84
11 Bmi1, stem cells, and senescence regulation. J Clin Invest 2004 3.80
12 Unravelling cancer stem cell potential. Nat Rev Cancer 2013 3.06
13 Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A 2006 2.06
14 Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest 2012 2.03
15 BMI1 sustains human glioblastoma multiforme stem cell renewal. J Neurosci 2009 1.85
16 BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci 2010 1.76
17 The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res 2008 1.56
18 BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res 2008 1.56
19 Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer. J Cancer Res Clin Oncol 2009 1.41
20 Cancer stem cells: A contentious hypothesis now moving forward. Cancer Lett 2013 1.40
21 Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem 2011 1.29
22 Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin Cancer Res 2006 1.23
23 Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study. J Cancer Res Clin Oncol 2008 1.21
24 Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death. Oncogene 2006 1.19
25 A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway. J Biol Chem 2012 1.07
26 Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma. PLoS One 2011 1.00
27 PTEN inhibits BMI1 function independently of its phosphatase activity. Mol Cancer 2009 0.97
28 Drug-induced QT interval prolongation: mechanisms and clinical management. Ther Adv Drug Saf 2012 0.94
29 Bmi1 confers resistance to oxidative stress on hematopoietic stem cells. PLoS One 2012 0.91
30 Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590. Lung Cancer 2007 0.89
31 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications. Med Res Rev 2015 0.88
32 BMI1 polycomb group protein acts as a master switch for growth and death of tumor cells: regulates TCF4-transcriptional factor-induced BCL2 signaling. PLoS One 2013 0.86
33 Bmi1 gene silencing inhibits the proliferation and invasiveness of human hepatocellular carcinoma cells and increases their sensitivity to 5-fluorouracil. Oncol Rep 2012 0.82
34 Silencing of Bmi-1 gene by RNA interference enhances sensitivity to doxorubicin in breast cancer cells. Indian J Exp Biol 2011 0.82
35 Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy. Cancer Sci 2015 0.81
Next 100