Phase II: Pembrolizumab/Carboplatin/Taxol in Epithelial Ovary Cancer

Clinical Trial ID NCT02766582

PubWeight™ 1.68‹?›

🔗 Visit the ClinicalTrials.gov page for NCT02766582

Top papers

Rank Title Journal Year PubWeight™‹?›
1 New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009 77.71
2 Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012 52.99
3 Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004 22.96
4 Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013 17.53
5 Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010 17.13
6 Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003 16.62
7 Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 2013 13.22
8 Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med 1996 11.72
9 Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A 2005 10.89
10 Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011 8.93
11 Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 2003 8.31
12 Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006 8.21
13 Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014 8.11
14 Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011 7.69
15 Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A 2007 7.49
16 Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013 7.42
17 Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial. Lancet 2009 6.65
18 Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol 2002 6.51
19 Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of Cancer and Leukemia Group B protocol 9840. J Clin Oncol 2008 4.09
20 Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med 2012 3.92
21 Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trial. Lancet Oncol 2013 3.70
22 High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol 2010 3.06
23 Sample sizes based on the log-rank statistic in complex clinical trials. Biometrics 1988 2.97
24 Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis. Gynecol Oncol 2011 2.67
25 The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma. Am J Obstet Gynecol 1994 2.50
26 FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. Semin Surg Oncol 1994 2.10
27 Reliability and validity of the functional assessment of cancer therapy-ovarian. J Clin Oncol 2001 2.05
28 The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee. Clin Cancer Res 2010 1.85
29 Issues in using progression-free survival when evaluating oncology products. J Clin Oncol 2009 1.78
30 Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res 2013 1.78
31 Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer 2010 1.68
32 Role of sensitivity analyses in assessing progression-free survival in late-stage oncology trials. J Clin Oncol 2009 1.53
33 Role of cytoreductive surgical treatment in the management of advanced ovarian cancer. Cancer Treat Rep 1979 1.50
34 Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer. Int J Cancer 2013 1.27
35 Improved therapeutic index of carboplatin plus cyclophosphamide versus cisplatin plus cyclophosphamide: final report by the Southwest Oncology Group of a phase III randomized trial in stages III and IV ovarian cancer. J Clin Oncol 1992 1.26
36 Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res 2010 1.24
37 The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer. PLoS One 2013 1.22
38 Immunotherapy for ovarian cancer: what's next? J Clin Oncol 2010 1.17
39 Cisplatin-cyclophosphamide versus carboplatin-cyclophosphamide in advanced ovarian cancer: a randomized phase III study of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1992 1.15
40 Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy. Clin Immunol 2008 1.12
41 Dose-dense chemotherapy improves mechanisms of antitumor immune response. Cancer Res 2012 0.99
42 Medicine. Keeping tabs on tumor DNA. Science 2010 0.98
43 Designing complex group sequential survival trials. Stat Med 2002 0.97
44 Immune Checkpoint Inhibitors: A New Opportunity in the Treatment of Ovarian Cancer? Int J Mol Sci 2016 0.90
45 STATing the importance of immune modulation by platinum chemotherapeutics. Oncoimmunology 2012 0.89
46 Circulating cell-free nucleic acids: promising biomarkers of hepatocellular carcinoma. Semin Oncol 2012 0.89
47 The Immune adjuvant properties of front-line carboplatin-paclitaxel: a randomized phase 2 study of alternative schedules of intravenous oregovomab chemoimmunotherapy in advanced ovarian cancer. J Immunother 2009 0.88
48 Immunotherapy for ovarian cancer: recent advances and perspectives. Curr Opin Oncol 2014 0.82
49 Repopulation of ovarian cancer cells after chemotherapy. Cancer Growth Metastasis 2013 0.82
50 The role of immune checkpoint inhibition in the treatment of ovarian cancer. Gynecol Oncol Res Pract 2016 0.81
51 Substantially modified ratios of effector to regulatory T cells during chemotherapy in ovarian cancer patients return to pre-treatment levels at completion: implications for immunotherapy. Cancers (Basel) 2012 0.77
52 Concomitant combination of active immunotherapy and carboplatin- or paclitaxel-based chemotherapy improves anti-tumor response. Cancer Immunol Immunother 2012 0.77
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