Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)

Clinical Trial ID NCT03092817

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med 2004 10.14
2 Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N Engl J Med 2011 7.13
3 Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis. N Engl J Med 2014 6.65
4 Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N Engl J Med 2011 6.42
5 Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 2008 5.94
6 Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 2009 5.75
7 Integration of antiretroviral therapy with tuberculosis treatment. N Engl J Med 2011 5.31
8 An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med 2006 5.02
9 Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis. N Engl J Med 2016 4.11
10 British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect 2009 3.92
11 Intensified regimen containing rifampicin and moxifloxacin for tuberculous meningitis: an open-label, randomised controlled phase 2 trial. Lancet Infect Dis 2012 3.86
12 Safety of 3 different reintroduction regimens of antituberculosis drugs after development of antituberculosis treatment-induced hepatotoxicity. Clin Infect Dis 2010 3.71
13 The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell 2010 3.64
14 Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis. N Engl J Med 2016 3.59
15 Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 2012 3.54
16 Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS 2010 2.83
17 TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell 2013 2.71
18 Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis. Clin Infect Dis 2011 2.70
19 Improving the bacteriological diagnosis of tuberculous meningitis. J Clin Microbiol 2004 2.60
20 Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med 2002 2.52
21 The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis. J Infect Dis 2005 2.38
22 Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis. J Infect Dis 2005 2.29
23 Tuberculous meningitis: more questions, still too few answers. Lancet Neurol 2013 2.26
24 Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol 2007 1.77
25 Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 2008 1.69
26 Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series. Clin Infect Dis 2009 1.62
27 Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol 2013 1.62
28 Effect of helminth-induced immunity on infections with microbial pathogens. Nat Immunol 2013 1.55
29 When to start antiretroviral therapy in HIV-associated tuberculosis. N Engl J Med 2011 1.52
30 The bacteriological diagnosis of tuberculous meningitis. J Clin Pathol 1953 1.49
31 Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol Rev 2015 1.45
32 A randomized, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1-associated pleural tuberculosis. J Infect Dis 2004 1.39
33 The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses. J Immunol 2005 1.38
34 Frequency, severity, and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome. Clin Infect Dis 2012 1.35
35 Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2014 1.30
36 The management of anti-tuberculosis drug-induced hepatotoxicity. Int J Tuberc Lung Dis 2001 1.18
37 Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting. PLoS One 2011 1.18
38 Cerebrospinal fluid drug concentrations and the treatment of tuberculous meningitis. Am Rev Respir Dis 1993 1.14
39 Surgical outcome of tuberculous meningitis hydrocephalus treated by endoscopic third ventriculostomy: prognostic factors and postoperative neuroimaging for functional assessment of ventriculostomy. J Neurosurg Pediatr 2009 1.13
40 Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. J Infect Dis 2013 1.12
41 HIV-associated tuberculous meningitis--diagnostic and therapeutic challenges. Tuberculosis (Edinb) 2010 1.12
42 Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis. Antimicrob Agents Chemother 2011 1.10
43 Cox regression methods for two-stage randomization designs. Biometrics 2007 1.09
44 Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial. J Neurol Sci 2010 1.08
45 Incidence of and risk factors for severe liver toxicity in HIV-infected patients on anti-tuberculosis treatment. Int J Tuberc Lung Dis 2007 1.04
46 The neurosurgical and acute care management of tuberculous meningitis: evidence and current practice. Tuberculosis (Edinb) 2010 1.03
47 Outcome of tuberculous meningitis at 6 and 12 months: a multiple regression analysis. Int J Tuberc Lung Dis 1999 1.00
48 Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management. J Clin Exp Hepatol 2012 0.99
49 Optic nerve sonography: A noninvasive means of detecting raised intracranial pressure in a resource-limited setting. J Neurosci Rural Pract 2016 0.98
50 The role of aspirin in childhood tuberculous meningitis. J Child Neurol 2011 0.97
51 Techniques for assessment of intravascular volume in critically ill patients. J Intensive Care Med 2009 0.97
52 Impact of drug resistance on clinical outcome in children with tuberculous meningitis. Pediatr Infect Dis J 2012 0.97
53 Tuberculous hydrocephalus: comparison of different treatments with regard to ICP, ventricular size and clinical outcome. Dev Med Child Neurol 1991 0.93
54 Outcome and determinants of mortality in 269 patients with combination anti-tuberculosis drug-induced liver injury. J Gastroenterol Hepatol 2013 0.93
55 Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 2016 0.93
56 The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life. BMC Med 2014 0.90
57 Advances in the diagnosis and treatment of tuberculous meningitis. Curr Opin Neurol 2013 0.90
58 Influence of antituberculosis drug resistance and Mycobacterium tuberculosis lineage on outcome in HIV-associated tuberculous meningitis. Antimicrob Agents Chemother 2012 0.89
59 The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women. J Acquir Immune Defic Syndr 2014 0.86
60 Evaluation of cerebral infarction in tuberculous meningitis by diffusion weighted imaging. J Infect 2008 0.86
61 Clinical and laboratory characteristics of cerebral infarction in tuberculous meningitis: a comparative study. J Clin Neurosci 2007 0.83
62 Neutrophil-associated central nervous system inflammation in tuberculous meningitis immune reconstitution inflammatory syndrome. Clin Infect Dis 2014 0.83
63 Tuberculosis and diabetes: current state and future perspectives. Trop Med Int Health 2016 0.81
64 Hyponatraemia and hypovolemic shock with tuberculous meningitis. Indian J Pediatr 2003 0.80
65 Cerebral infarction and neurodevelopmental outcome in childhood tuberculous meningitis. Eur J Paediatr Neurol 2008 0.80
66 Modulation of pro- and anti-inflammatory cytokines in active and latent tuberculosis by coexistent Strongyloides stercoralis infection. Tuberculosis (Edinb) 2015 0.78
67 Clinical characteristics and treatment delay of cerebral infarction in tuberculous meningitis. Intern Med J 2010 0.77
68 Bedside sonographic measurement of optic nerve sheath diameter as a predictor of intracranial pressure in ED. Am J Emerg Med 2016 0.76
69 Nurse-delivered focused echocardiography to determine intravascular volume status in a deployed maritime critical care unit. J R Nav Med Serv 2015 0.75
70 Rapid diagnosis of tuberculous meningitis. J Infect 1993 0.75
71 Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis. J Clin Microbiol 2014 0.75
72 Cerebral salt wasting in tuberculous meningitis: Two cases and review of the literature. Case Report. Neuro Endocrinol Lett 2015 0.75
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