PubRank

Metformin Pharmacology in Human Cancers: A Proof of Principle Study

Clinical Trial ID NCT03477162

PubWeight™ 0.00‹?›

🔗 Visit the ClinicalTrials.gov page for NCT03477162

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998 34.34
2 Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001 23.21
3 Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2008 21.05
4 Metformin and reduced risk of cancer in diabetic patients. BMJ 2005 13.04
5 Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 2009 10.18
6 Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000 6.86
7 Diabetes and cancer: a consensus report. Diabetes Care 2010 6.71
8 Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 1995 6.51
9 New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009 6.17
10 Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med 2007 6.09
11 Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 2007 5.45
12 Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 2009 4.72
13 Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007 4.47
14 Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 2010 4.36
15 Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) 2012 4.04
16 Long-term metformin use is associated with decreased risk of breast cancer. Diabetes Care 2010 3.68
17 Metformin: taking away the candy for cancer? Eur J Cancer 2010 2.68
18 Clinical pharmacokinetics of metformin. Clin Pharmacokinet 2011 2.59
19 Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 2011 2.54
20 Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study. Cancer Causes Control 2009 2.49
21 Metformin kinetics in healthy subjects and in patients with diabetes mellitus. Br J Clin Pharmacol 1981 2.38
22 The blooming of the French lilac. J Clin Invest 2001 1.80
23 Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care 2012 1.78
24 Molecular mechanism of action of metformin: old or new insights? Diabetologia 2013 1.71
25 Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat 2010 1.67
26 The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c. Pharmacogenet Genomics 2011 1.52
27 Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. J Am Med Inform Assoc 2014 1.25
28 Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J Clin Endocrinol Metab 2003 1.15
29 Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling. Transl Oncol 2013 1.12
30 Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: mechanisms and management. Ann Intern Med 2003 1.03
31 Steady-state pharmacokinetics of a novel extended-release metformin formulation. Clin Pharmacokinet 2005 0.96
32 Repurposing metformin for cancer treatment: current clinical studies. Oncotarget 2016 0.95
33 Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy. Cell Metab 2016 0.90
34 Metformin in breast cancer - an evolving mystery. Breast Cancer Res 2015 0.79
35 Obesity and cancer, a case for insulin signaling. Cell Death Dis 2015 0.79
36 Therapeutic Concentrations of Metformin: A Systematic Review. Clin Pharmacokinet 2016 0.75
37 Photoacoustic depth profiling of a skin model for non-invasive glucose measurement. Conf Proc IEEE Eng Med Biol Soc 2008 0.75
Next 100