Elderly Cancer PatIents, Safety and qualiTy of Life Under immunOtheraPies (EPITOP-01)

Clinical Trial ID NCT03673332

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969 45.63
2 Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001 42.21
3 STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION. JAMA 1963 38.91
4 Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012 35.24
5 The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991 31.17
6 Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011 26.90
7 Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med 2015 14.71
8 Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 2015 12.74
9 Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. N Engl J Med 2015 12.54
10 Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 2015 11.98
11 Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992 8.86
12 Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 2006 8.00
13 Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med 2016 6.84
14 Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 2014 5.65
15 Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol 2011 5.41
16 The mini-cog: a cognitive 'vital signs' measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry 2000 4.75
17 The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc 2003 3.79
18 Patient versus clinician symptom reporting using the National Cancer Institute Common Terminology Criteria for Adverse Events: results of a questionnaire-based study. Lancet Oncol 2006 3.75
19 PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma. N Engl J Med 2016 2.54
20 Management of cancer in the older person: a practical approach. Oncologist 2000 2.50
21 The applications of PROs in clinical practice: what are they, do they work, and why? Qual Life Res 2008 2.47
22 Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 2016 2.25
23 Measurement and impact of comorbidity in older cancer patients. Crit Rev Oncol Hematol 2000 2.12
24 Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol 2015 1.90
25 Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol 2012 1.66
26 Using reference data on quality of life--the importance of adjusting for age and gender, exemplified by the EORTC QLQ-C30 (+3). Eur J Cancer 1998 1.60
27 Hyperprogressive disease (HPD) is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1. Clin Cancer Res 2016 1.60
28 High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin Exp Immunol 1987 1.59
29 Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34. Immunogenetics 1990 1.26
30 Multiple chronic health problems are negatively associated with health related quality of life (HRQoL) irrespective of age. Qual Life Res 2000 1.15
31 Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial. Lancet Oncol 2016 1.14
32 Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab. JAMA Dermatol 2016 1.04
33 Reliability and validity of questions about exercise in the Canadian Study of Health and Aging. Int Psychogeriatr 2001 1.01
34 Four Instrumental Activities of Daily Living Score as a predictor of one-year incident dementia. Age Ageing 1993 0.95
35 [Development and contribution to the validation of a brief French version of the Yesavage Geriatric Depression Scale]. Encephale 1997 0.89
36 International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer. Br J Cancer 2013 0.86
37 The development of immunotherapy in older adults: New treatments, new toxicities? J Geriatr Oncol 2016 0.86
38 A systematic review of the use and validation of health-related quality of life instruments in older cancer patients. Eur J Cancer 2008 0.86
39 Comparative performance of long and short forms of the Geriatric Depression Scale in mildly demented Chinese. Int J Geriatr Psychiatry 2005 0.81
40 Anorexia as an independent predictor of mortality. J Am Geriatr Soc 2005 0.77
41 Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review. Ann Oncol 2017 0.75
42 Immune checkpoint inhibitors and elderly people: A review. Eur J Cancer 2017 0.75
43 [Innovative therapies for metastatic melanoma in elderly patients]. Ann Dermatol Venereol 2015 0.75
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