Identification of Predictive Biomarkers for Response to Biologic Therapies in Inflammatory Bowel Disease (BioIBD)

Clinical Trial ID NCT03885713

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 2004 14.78
2 Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010 12.35
3 Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest Endosc 2004 4.12
4 Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol 2011 3.97
5 A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2006 3.68
6 A deep profiler's guide to cytometry. Trends Immunol 2012 3.14
7 Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 2012 3.02
8 Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011 2.96
9 The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol 2010 2.74
10 Once-daily, high-concentration MMX mesalamine in active ulcerative colitis. Gastroenterology 2006 2.34
11 Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis. Gut 2009 2.08
12 Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 2014 1.62
13 Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target. Am J Gastroenterol 2015 1.44
14 Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 2017 1.39
15 Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut 2006 1.32
16 Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics 2006 1.30
17 Trends in hospitalization rates for inflammatory bowel disease in the United States. Clin Gastroenterol Hepatol 2007 1.30
18 Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease. J Crohns Colitis 2011 1.29
19 CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages. Cell Rep 2014 1.28
20 Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease. J Proteome Res 2007 1.13
21 Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases. Proteomics 2002 1.13
22 Mass Cytometry: Single Cells, Many Features. Cell 2016 1.13
23 Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab. Inflamm Bowel Dis 2010 1.10
24 Inflammatory bowel disease: an expanding global health problem. Clin Med Insights Gastroenterol 2013 1.07
25 Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides. Inflamm Bowel Dis 2010 1.06
26 Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease. Inflamm Bowel Dis 2010 1.02
27 Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli. J Biol Chem 2004 1.02
28 Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn's disease. Aliment Pharmacol Ther 2014 1.01
29 Towards personalized care in IBD. Nat Rev Gastroenterol Hepatol 2013 1.00
30 Host-microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal-luminal interface. Inflamm Bowel Dis 2011 0.97
31 Predicting response to Anti-TNF Agents for the treatment of crohn's disease. Therap Adv Gastroenterol 2009 0.96
32 Proteomics for prediction and characterization of response to infliximab in Crohn's disease: a pilot study. Clin Biochem 2008 0.95
33 IOIBD technical review on endoscopic indices for Crohn's disease clinical trials. Gut 2015 0.92
34 Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl 2013 0.92
35 Serum protein profiling in patients with inflammatory bowel diseases using selective solid-phase bulk extraction, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemometric data analysis. Rapid Commun Mass Spectrom 2007 0.91
36 Mucosal cytokine gene expression profiles as biomarkers of response to infliximab in ulcerative colitis. Scand J Gastroenterol 2012 0.90
37 Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets. Immunity 2016 0.88
38 A systematic review of measurement of endoscopic disease activity and mucosal healing in Crohn's disease: recommendations for clinical trial design. Inflamm Bowel Dis 2014 0.87
39 TNF-alpha gene expression in colorectal mucosa as a predictor of remission after induction therapy with infliximab in ulcerative colitis. Cytokine 2009 0.87
40 Differential proteomic analysis of HT29 Cl.16E and intestinal epithelial cells by LC ESI/QTOF mass spectrometry. J Proteomics 2009 0.87
41 Systematic review: predicting and optimising response to anti-TNF therapy in Crohn's disease - algorithm for practical management. Aliment Pharmacol Ther 2015 0.85
42 Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy. Arthritis Res Ther 2015 0.85
43 Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn's disease. Aliment Pharmacol Ther 2015 0.85
44 Label-free quantification for discovering novel biomarkers in the diagnosis and assessment of disease activity in inflammatory bowel disease. J Dig Dis 2013 0.84
45 Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing. J Crohns Colitis 2011 0.83
46 Usefulness of oral beclometasone dipropionate in the treatment of active ulcerative colitis in clinical practice: the RECLICU Study. J Crohns Colitis 2010 0.82
47 Challenges to the design, execution, and analysis of randomized controlled trials for inflammatory bowel disease. Gastroenterology 2012 0.82
48 Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis. Gastroenterology 2015 0.81
49 Health Care Cost Analysis in a Population-based Inception Cohort of Inflammatory Bowel Disease Patients in the First Year of Diagnosis. J Crohns Colitis 2015 0.79
50 Current evidence supporting mucosal healing and deep remission as important treatment goals for inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2016 0.77
51 The Risk of Relapse after Anti-TNF Discontinuation in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Am J Gastroenterol 2016 0.77
52 Global mucosal and serum cytokine profile in patients with ulcerative colitis undergoing anti-TNF therapy. Scand J Gastroenterol 2015 0.76
53 Predicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel disease. Therap Adv Gastroenterol 2016 0.76
54 Clinical Response to Vedolizumab in Ulcerative Colitis Patients Is Associated with Changes in Integrin Expression Profiles. Front Immunol 2017 0.76
55 Endoscopy in inflammatory bowel disease: advances in disease management. Gastrointest Endosc 2017 0.75
56 Can We Predict the Efficacy of Anti-TNF-α Agents? Int J Mol Sci 2017 0.75
57 Advances in the use of biologics and other novel drugs for managing inflammatory bowel disease. Curr Opin Pharmacol 2017 0.75
58 Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease. Front Immunol 2017 0.75
59 Physiological intermolecular modification spectroscopy for the prediction of response to anti-tumor necrosis factor therapy in patients with inflammatory bowel diseases. Dig Dis 2014 0.75
60 Usefulness of Transcriptional Blood Biomarkers as a Non-invasive Surrogate Marker of Mucosal Healing and Endoscopic Response in Ulcerative Colitis. J Crohns Colitis 2017 0.75
61 Predictors of tissue healing in ulcerative colitis patients treated with anti-TNF. Dig Liver Dis 2016 0.75
62 Characterizing unmet medical need and the potential role of new biologic treatment options in patients with ulcerative colitis and Crohn's disease: a systematic review and clinician surveys. Eur J Gastroenterol Hepatol 2015 0.75
63 Ustekinumab to treat Crohn's disease. Gastroenterol Hepatol 2017 0.75
64 Efficacy and safety of vedolizumab in the treatment of ulcerative colitis. Gastroenterol Hepatol 2016 0.75
65 [Vedolizumab in the treatment of Crohn's disease]. Gastroenterol Hepatol 2015 0.75
66 Serum Interleukin 9 Levels Predict Disease Severity and the Clinical Efficacy of Infliximab in Patients with Crohn's Disease. Inflamm Bowel Dis 2017 0.75
67 The expanding therapeutic armamentarium for inflammatory bowel disease: how to choose the right drug(s) for our patients? J Crohns Colitis 2017 0.75
68 Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma. Hepatology 2017 0.75
69 Noninvasive biomarkers as surrogate predictors of clinical and endoscopic remission after infliximab induction in patients with refractory ulcerative colitis. Saudi J Gastroenterol 2017 0.75
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