Allogeneic MSC Treatment for Pulmonary Emphysema

Clinical Trial ID NCT04918706

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Multilineage potential of adult human mesenchymal stem cells. Science 1999 66.19
2 A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008 17.19
3 Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008 12.59
4 Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008 11.14
5 A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 2003 10.40
6 Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 2006 5.93
7 Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal Chem 2009 4.95
8 Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med 1999 4.65
9 Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res 2009 4.58
10 Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000 3.94
11 Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 2013 3.01
12 Stem cell transplantation: the lung barrier. Transplant Proc 2007 2.76
13 Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation. N Engl J Med 2015 2.59
14 Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant 1995 2.35
15 New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2011 2.23
16 Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest 2012 1.85
17 Endothelial microparticles in mild chronic obstructive pulmonary disease and emphysema. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease study. Am J Respir Crit Care Med 2013 1.64
18 Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J 2003 1.20
19 Alpha2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling. J Biol Chem 2010 1.16
20 Lung tissue engineering technique with adipose stromal cells improves surgical outcome for pulmonary emphysema. Am J Respir Crit Care Med 2006 1.05
21 International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials. Cytotherapy 2015 0.95
22 Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. Elife 2015 0.94
23 Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med 2017 0.94
24 Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets. Immunity 2016 0.88
25 Emphysema--a disease of small airways or lung parenchyma? N Engl J Med 2011 0.85
26 CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A 2015 0.84
27 Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress. Am J Respir Cell Mol Biol 2014 0.84
28 Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro. Exp Lung Res 2013 0.84
29 Unraveling mechanisms of mesenchymal stromal cell-mediated immunomodulation through patient monitoring and product characterization. Ann N Y Acad Sci 2015 0.79
30 Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage. Am J Respir Crit Care Med 2016 0.78
31 A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema. QJM 2016 0.77
32 TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor. Respir Res 2016 0.77
33 Annual FEV1 changes and numbers of circulating endothelial microparticles in patients with COPD: a prospective study. BMJ Open 2014 0.76
34 Lung volume reduction surgery for diffuse emphysema. Cochrane Database Syst Rev 2016 0.75
35 The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD). Respir Res 2017 0.75
36 Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients. ERJ Open Res 2016 0.75
37 Structural and functional characterization of endothelial microparticles released by cigarette smoke. Sci Rep 2016 0.75
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