Top clinical trials

Rank Clinical Trial PubWeight™‹?›
101 Genetic Architecture of Plasma T-PA and PAI-1 60.28
102 Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) 59.26
103 Diabetes Prevention Program 58.96
104 An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene 58.55
105 Secondary Prevention of Small Subcortical Strokes Trial (SPS3) 58.05
106 Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations (LCA) 57.82
107 Asthma Clinical Research Network (ACRN) 57.63
108 Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis 57.43
109 Systolic Blood Pressure Intervention Trial (SPRINT) 56.84
110 Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease (STICH) 56.53
111 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) 56.51
112 Effect of Male Circumcision on HIV Incidence (ANRS 1265) 56.51
113 A Study of Trastuzumab Emtansine (T-DM1) Plus Pertuzumab/Pertuzumab Placebo Versus Trastuzumab [Herceptin] Plus a Taxane in Patients With Metastatic Breast Cancer (MARIANNE) 55.92
114 Bicalutamide in Treating Patients With Metastatic Breast Cancer 55.84
115 A Study of an Anti-KIR Antibody in Combination With an Anti-PD1 Antibody in Patients With Advanced Solid Tumors 55.80
116 Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Advanced Dry Age Related Macular Degeneration (Dry AMD) 55.39
117 Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation 55.37
118 First Line IRESSA™ Versus Carboplatin/Paclitaxel in Asia (IPASS) 55.10
119 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community 55.10
120 Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE (HPS2-THRIVE) 55.09
121 Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction 55.08
122 Safety and Effectiveness Study of a Candidate Vaginal Microbicide for Prevention of HIV 55.06
123 The Research Registry for Neonatal Lupus 54.78
124 Insulin Resistance Atherosclerosis Study (IRAS) 54.77
125 Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure 54.50
126 Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD) 54.39
127 Does Saxagliptin Reduce the Risk of Cardiovascular Events When Used Alone or Added to Other Diabetes Medications (SAVOR- TIMI 53) 53.70
128 A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention 53.18
129 BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME). 53.07
130 Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS) 52.55
131 Women's Ischemia Syndrome Evaluation (WISE) 52.45
132 Study of Nivolumab (BMS-936558) Compared With Dacarbazine in Untreated, Unresectable, or Metastatic Melanoma (CheckMate 066) 52.45
133 A Study of Trastuzumab Emtansine Versus Capecitabine + Lapatinib in Participants With HER2-positive Locally Advanced or Metastatic Breast Cancer (EMILIA) 52.30
134 Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT) (VADT) 52.28
135 Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 52.05
136 The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention) (ORIGIN) 52.04
137 Sub-retinal Transplantation of hESC Derived RPE(MA09-hRPE)Cells in Patients With Stargardt's Macular Dystrophy 51.98
138 Comparison of Surgical Procedures to Reduce Urinary Stress Incontinence (SISTEr) 51.98
139 A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma 51.86
140 Strategic Timing of Antiretroviral Treatment (START) 51.73
141 Nivolumab (BMS-936558; MDX-1106) in Combination With Sunitinib, Pazopanib, or Ipilimumab in Subjects With Metastatic Renal Cell Carcinoma (RCC) (CheckMate 016) 51.61
142 A Study to Compare rhuFab V2 With Verteporfin Photodynamic in Treating Subfoveal Neovascular Macular Degeneration 51.09
143 Longitudinal Study of Ocular Complications of AIDS (LSOCA) (LSOCA) 50.58
144 Inflammation and the Host Response to Injury (Trauma) 50.53
145 CAR T Cell Receptor Immunotherapy for Patients With B-cell Lymphoma 50.46
146 Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study (0954-133) 50.24
147 A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare 49.76
148 Letrozole or Tamoxifen in Treating Postmenopausal Women With Breast Cancer (BIG 1-98) 49.73
149 Ph I Ipilimumab Vemurafenib Combo in Patients With v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) 49.69
150 S0000 Selenium and Vitamin E in Preventing Prostate Cancer (SELECT) 49.25
151 A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers 49.02
152 IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) 48.93
153 ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) 48.66
154 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 48.45
155 Neighborhood Environments and Cardiovascular Disease 48.23
156 Infant Aphakia Treatment Study (IATS) (IATS) 48.11
157 Provenge® (Sipuleucel-T) Active Cellular Immunotherapy Treatment of Metastatic Prostate Cancer After Failing Hormone Therapy 47.94
158 A Study of Avastin® (Bevacizumab) in Combination With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Glioblastoma 47.90
159 Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma (COMBI-v) 47.32
160 "REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk (REDUCE) 47.27
161 Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity 47.16
162 CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII 46.99
163 Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) (MTA) 46.87
164 A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung (PROFILE 1014) 46.83
165 Male Circumcision and HIV Rates in Kenya 46.81
166 Study Comparing Orteronel Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer 46.59
167 Investigation of V520 in an HIV Vaccine Proof-of-Concept Study (V520-023) 46.44
168 Sitagliptin Cardiovascular Outcomes Study (MK-0431-082) (TECOS) 45.50
169 Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 45.17
170 Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study (APACE) 44.96
171 Induction Erlotinib Therapy in Stage III A (N2) Non-Small Cell Lung Cancer (NSCLC) 44.88
172 Inflammation, Infection, and Future Cardiovascular Risk 44.83
173 Safety Study of IL-21/Anti-PD-1 Combination in the Treatment of Solid Tumors 44.77
174 CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes 44.59
175 A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis 44.56
176 Organized Program To Initiate Lifesaving Treatment In Hospitalized Patients With Heart Failure (OPTIMIZE-HF) 44.37
177 Safety Study of Nivolumab by Itself or in Combination in Patients With Lymphoma or Multiple Myeloma 44.33
178 Chemoradiotherapy of Capecitabine With or Without Oxaliplatin Versus Cisplatin-5-FU for Esophageal Squamous Cancer (CRTCOESC) 44.33
179 Target Temperature Management After Cardiac Arrest (TTM) 44.29
180 Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer 44.27
181 Safety and Effectiveness of TFV 1% Gel, TDF Tablets, and FTC/TDF Tablets in Preventing HIV in Women 44.01
182 OSI-774 (Tarceva) in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer 43.96
183 A Multicenter, Open-label, Phase 3 Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Versus Chlorambucil in Patients 65 Years or Older With Treatment-naive Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (RESONATE™-2) 43.64
184 Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) 43.53
185 A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome 43.16
186 Phase I/IIA Study of CART19 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma (Pedi CART19) 43.06
187 Trastuzumab in Treating Women With Primary Breast Cancer 43.00
188 Molecular Genetics of Schizophrenia 42.93
189 A Study of Vemurafenib in Previously Treated Patients With Metastatic Melanoma 42.84
190 Occluded Artery Trial (OAT) (OAT) 42.74
191 Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier) 42.56
192 Rapid Antidepressant Effects of Ketamine in Major Depression 42.55
193 Efficacy of GSK Biologicals' Candidate Malaria Vaccine 257049 Against Malaria Disease in Infants and Children in Africa 42.35
194 Phase 3 Trial in Squamous Non Small Cell Lung Cancer Subjects Comparing Ipilimumab Versus Placebo in Addition to Paclitaxel and Carboplatin 42.28
195 Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia 42.06
196 A Study to Compare BMS-936558 to the Physician's Choice of Either Dacarbazine or Carboplatin and Paclitaxel in Advanced Melanoma Patients That Have Progressed Following Anti-CTLA-4 Therapy (CheckMate 037) 42.03
197 Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY) 41.90
198 National Emphysema Treatment Trial (NETT) 41.86
199 A Phase 1b Study of Atezolizumab in Combination With Vemurafenib or Vemurafenib Plus Cobimetinib in Participants With BRAFV600-Mutation Positive Metastatic Melanoma 41.85
200 Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole (BOLERO-2) 41.74
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