| Rank |
Title |
Year |
PubWeight™‹?› |
|
1
|
A membrane-filter technique for the detection of complementary DNA.
|
1966
|
71.25
|
|
2
|
Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.
|
1967
|
32.60
|
|
3
|
Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.
|
1978
|
32.33
|
|
4
|
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
|
1984
|
20.07
|
|
5
|
On the size of the active site in proteases. I. Papain.
|
1967
|
18.32
|
|
6
|
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
|
1999
|
14.25
|
|
7
|
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
|
1997
|
14.09
|
|
8
|
Sedimentation characteristics of rapidly labelled RNA from HeLa cells.
|
1962
|
13.89
|
|
9
|
Transfer of small DNA fragments from polyacrylamide gels to diazobenzyloxymethyl-paper and detection by hybridization with DNA probes.
|
1978
|
12.71
|
|
10
|
Analysis of C14-labeled proteins by disc electrophoresis.
|
1965
|
11.32
|
|
11
|
Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease.
|
1973
|
10.81
|
|
12
|
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
|
2006
|
10.69
|
|
13
|
Guideline to reference gene selection for quantitative real-time PCR.
|
2004
|
10.03
|
|
14
|
Conversion of methionine to ethylene in vegetative tissue and fruits.
|
1967
|
9.33
|
|
15
|
Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli.
|
1969
|
9.20
|
|
16
|
Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.
|
1983
|
9.18
|
|
17
|
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
|
2000
|
9.09
|
|
18
|
DNA polymerase as a requirement for the maintenance of the bacterial plasmid colicinogenic factor E1.
|
1970
|
8.73
|
|
19
|
Nitric oxide: a cytotoxic activated macrophage effector molecule.
|
1988
|
8.17
|
|
20
|
Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein.
|
1984
|
8.14
|
|
21
|
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
|
1986
|
7.96
|
|
22
|
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.
|
1997
|
7.87
|
|
23
|
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation.
|
1988
|
7.77
|
|
24
|
Acetylene inhibition of nitrous oxide reduction by denitrifying bacteria.
|
1976
|
7.76
|
|
25
|
Stimulation of glyceraldehyde-3-phosphate dehydrogenase mRNA levels by endogenous nitric oxide in cytokine-activated endothelium.
|
1995
|
7.57
|
|
26
|
Phosphoglycolate production catalyzed by ribulose diphosphate carboxylase.
|
1971
|
7.51
|
|
27
|
Extensive modulation of a set of microRNAs in primary glioblastoma.
|
2005
|
7.50
|
|
28
|
Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity.
|
1972
|
7.50
|
|
29
|
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells.
|
1989
|
7.39
|
|
30
|
Release of lipopolysaccharide by EDTA treatment of E. coli.
|
1965
|
7.38
|
|
31
|
Identification of the outer membrane protein of E. coli that produces transmembrane channels in reconstituted vesicle membranes.
|
1976
|
7.31
|
|
32
|
Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.
|
1983
|
7.26
|
|
33
|
Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes.
|
1975
|
7.15
|
|
34
|
Optimised parameters for A-DNA and B-DNA.
|
1972
|
7.06
|
|
35
|
A partial characterization of indoleacetylinositols from ZEA mays.
|
1965
|
6.90
|
|
36
|
A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules.
|
1980
|
6.64
|
|
37
|
Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation.
|
2001
|
6.60
|
|
38
|
Enterobactin, an iron transport compound from Salmonella typhimurium.
|
1970
|
6.60
|
|
39
|
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue.
|
1985
|
6.57
|
|
40
|
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.
|
1995
|
6.55
|
|
41
|
Cloning of genomic DNA for human atrial natriuretic factor.
|
1984
|
6.53
|
|
42
|
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.
|
1974
|
6.53
|
|
43
|
Positive regulatory gene for temperature-controlled proteins in Escherichia coli.
|
1981
|
6.35
|
|
44
|
TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal.
|
1999
|
6.33
|
|
45
|
Alkaline transfer of DNA to plastic membrane.
|
1984
|
6.32
|
|
46
|
A method for the detection of RNA-DNA complexes.
|
1963
|
6.20
|
|
47
|
An extracellular H2O2-requiring enzyme preparation involved in lignin biodegradation by the white rot basidiomycete Phanerochaete chrysosporium.
|
1983
|
6.04
|
|
48
|
Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae.
|
1995
|
5.89
|
|
49
|
Validation of housekeeping genes as internal control for studying gene expression in rice by quantitative real-time PCR.
|
2006
|
5.83
|
|
50
|
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
|
1999
|
5.83
|