The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther)

Journal PubWeight™ 21143.60‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 A method for the fluorometric assay of histamine in tissues. 1959 16.61
2 A simplified method of evaluating dose-effect experiments. 1949 13.89
3 A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. 1962 11.93
4 Studies on behavior. IV. Stimulant actions of methamphetamine. 1958 11.80
5 Effects of various centrally acting drugs on fighting behavior of mice. 1959 11.19
6 Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. 1985 9.91
7 The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. 1976 9.13
8 Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. 1953 8.48
9 A simple, sensitive method for the assay of adenyl cyclase. 1968 8.05
10 Pharmacology of the neuromuscular junction. 1950 7.13
11 Functional selectivity and classical concepts of quantitative pharmacology. 2006 7.03
12 Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. 1981 6.71
13 Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol. 1958 6.27
14 p-Chlorophenylalanine: a specific depletor of brain serotonin. 1966 5.52
15 The histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. 1955 5.42
16 A method for rapid graphic solution of time-per cent effect curves. 1949 5.31
17 The elimination of enzymatic diffusion artifacts in the histochemical localization of cholinesterases and a survey of their cellular distributions. 1951 5.23
18 Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. 1973 5.23
19 Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. 1994 5.22
20 Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. 1953 5.14
21 Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. 2000 5.09
22 Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. 1975 5.07
23 The histochemical differentiation of types of cholinesterases and their localizations in tissues of the cat. 1950 4.80
24 Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. 1973 4.40
25 Dibenamine blockade in strips of rabbit aorta and its use in differentiating receptors. 1954 4.36
26 Electromechanical and pharmacomechanical coupling in vascular smooth muscle. 1968 4.28
27 Biphasic development of carrageenin edema in rats. 1969 4.24
28 Pharmacological estimation of drug-receptor dissociation constants. Statistical evaluation. I. Agonists. 1971 4.23
29 [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. 1989 4.18
30 Identification and assay of serotonin in brain. 1956 4.17
31 Studies on behavior. I. Differential sensitivity to pentobarbital of pecking performance in pigeons depending on the schedule of reward. 1955 4.14
32 Drug synergism: its detection and applications. 2001 4.11
33 An unusual type of sympathetic ganglionic stimulant. 1961 4.05
34 The gastric secretion of drugs: a pH partition hypothesis. 1957 3.99
35 Fetal nicotine or cocaine exposure: which one is worse? 1998 3.90
36 Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. 1973 3.89
37 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. 2004 3.84
38 The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. 2003 3.71
39 Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. 2003 3.69
40 Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. 2002 3.67
41 The fate of H3-norepinephrine in animals. 1961 3.63
42 The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material. 1953 3.60
43 The site of action and active form of local anesthetics. II. Experiments with quaternary compounds. 1970 3.59
44 Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. 2001 3.59
45 Studies on behavior. II. The effects of pentobarbital, methamphetamine and scopolamine on performances in pigeons involving discriminations. 1955 3.59
46 Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. 1992 3.58
47 Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. 1990 3.55
48 Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics. 1959 3.50
49 Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. 2003 3.48
50 Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. 1981 3.47
Next 50