Science (New York, N.Y.) (Science)

Journal PubWeight™ 126635.94‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. 1988 220.77
2 The sequence of the human genome. 2001 101.55
3 Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. 1985 95.08
4 Emergence of scaling in random networks 1999 89.38
5 Quantitative monitoring of gene expression patterns with a complementary DNA microarray. 1995 88.48
6 The complete genome sequence of Escherichia coli K-12. 1997 84.27
7 Screening lambdagt recombinant clones by hybridization to single plaques in situ. 1977 83.82
8 Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. 1999 83.27
9 Rapid and sensitive protein similarity searches. 1985 76.83
10 The Evolution of Oxygen From Illuminated Suspensions of Frozen, Dried, and Homogenized Chloroplasts. 1946 74.78
11 The genome sequence of Drosophila melanogaster. 2000 74.32
12 Induced pluripotent stem cell lines derived from human somatic cells. 2007 71.50
13 Optimization by simulated annealing. 1983 71.02
14 Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. 1995 68.34
15 Multilineage potential of adult human mesenchymal stem cells. 1999 66.19
16 Embryonic stem cell lines derived from human blastocysts. 1998 65.53
17 Genome-wide mapping of in vivo protein-DNA interactions. 2007 64.92
18 The future of genetic studies of complex human diseases. 1996 64.76
19 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. 2004 61.56
20 Genome sequence of the nematode C. elegans: a platform for investigating biology. 1998 61.48
21 MENDELIAN PROPORTIONS IN A MIXED POPULATION. 1908 60.99
22 Exploring the metabolic and genetic control of gene expression on a genomic scale. 1997 60.15
23 Serial analysis of gene expression. 1995 60.15
24 The consensus coding sequences of human breast and colorectal cancers. 2006 60.02
25 Human malaria parasites in continuous culture. 1976 59.70
26 Optical coherence tomography. 1991 57.87
27 Translating the histone code. 2001 56.77
28 Multiplex genome engineering using CRISPR/Cas systems. 2013 55.53
29 Amino acid metabolism in mammalian cell cultures. 1959 55.21
30 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 2007 51.70
31 An integrated genomic analysis of human glioblastoma multiforme. 2008 51.36
32 The structure of haplotype blocks in the human genome. 2002 50.88
33 A genomic perspective on protein families. 1997 50.51
34 Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. 1987 49.88
35 Understanding the Warburg effect: the metabolic requirements of cell proliferation. 2009 49.82
36 Diversity of the human intestinal microbial flora. 2005 49.64
37 On the origin of cancer cells. 1956 49.55
38 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. 2002 49.51
39 The transcriptional landscape of the yeast genome defined by RNA sequencing. 2008 48.99
40 RNA-guided human genome engineering via Cas9. 2013 48.29
41 A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. 2012 48.17
42 TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. 1934 47.63
43 Environmental genome shotgun sequencing of the Sargasso Sea. 2004 45.23
44 Electric field effect in atomically thin carbon films. 2004 45.10
45 The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. 1968 45.05
46 Neighborhoods and violent crime: a multilevel study of collective efficacy. 1997 44.65
47 Identification of novel genes coding for small expressed RNAs. 2001 44.44
48 An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. 2001 44.16
49 Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). 1983 43.61
50 Two-photon laser scanning fluorescence microscopy. 1990 43.55
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