Cell

Journal PubWeight™ 55387.08‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 MicroRNAs: genomics, biogenesis, mechanism, and function. 2004 198.59
2 Hallmarks of cancer: the next generation. 2011 140.01
3 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. 2006 120.51
4 The hallmarks of cancer. 2000 113.05
5 Induction of pluripotent stem cells from adult human fibroblasts by defined factors. 2007 101.42
6 Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. 2005 96.87
7 MicroRNAs: target recognition and regulatory functions. 2009 92.17
8 High-resolution profiling of histone methylations in the human genome. 2007 85.74
9 The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. 1993 64.62
10 Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. 1977 61.24
11 Chromatin modifications and their function. 2007 55.98
12 Prediction of mammalian microRNA targets. 2003 53.70
13 A bivalent chromatin structure marks key developmental genes in embryonic stem cells. 2006 48.80
14 The physical map of the whole E. coli chromosome: application of a new strategy for rapid analysis and sorting of a large genomic library. 1987 46.35
15 The epithelial-mesenchymal transition generates cells with properties of stem cells. 2008 46.08
16 A genetic model for colorectal tumorigenesis. 1990 44.37
17 Pathogen recognition and innate immunity. 2006 44.14
18 Matrix elasticity directs stem cell lineage specification. 2006 43.00
19 Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. 1986 42.45
20 Epithelial-mesenchymal transitions in development and disease. 2009 39.17
21 WAF1, a potential mediator of p53 tumor suppression. 1993 38.72
22 The isolation of structural genes from libraries of eucaryotic DNA. 1978 37.13
23 A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. 1986 36.96
24 Integrins: bidirectional, allosteric signaling machines. 2002 36.25
25 TOR signaling in growth and metabolism. 2006 35.29
26 Core transcriptional regulatory circuitry in human embryonic stem cells. 2005 34.93
27 Autophagy in the pathogenesis of disease. 2008 34.68
28 SV40-transformed simian cells support the replication of early SV40 mutants. 1981 34.67
29 Integrins: versatility, modulation, and signaling in cell adhesion. 1992 34.06
30 A mammalian microRNA expression atlas based on small RNA library sequencing. 2007 34.03
31 The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. 2006 33.94
32 Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. 1993 33.79
33 The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. 1993 33.20
34 Highly integrated single-base resolution maps of the epigenome in Arabidopsis. 2008 32.65
35 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. 1999 32.32
36 Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. 1984 31.52
37 Functional discovery via a compendium of expression profiles. 2000 31.39
38 Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. 2004 31.38
39 AKT/PKB signaling: navigating downstream. 2007 31.26
40 The double-strand-break repair model for recombination. 1983 31.21
41 p53, the cellular gatekeeper for growth and division. 1997 31.04
42 The epigenomics of cancer. 2007 30.91
43 RAS is regulated by the let-7 microRNA family. 2005 30.24
44 Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. 2007 30.22
45 Wnt/beta-catenin signaling in development and disease. 2006 30.09
46 High resolution two-dimensional electrophoresis of basic as well as acidic proteins. 1977 30.04
47 The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. 1992 30.02
48 Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. 2004 29.32
49 mTOR signaling in growth control and disease. 2012 29.21
50 Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. 1997 29.13
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