Journal of molecular biology (J Mol Biol)

Journal PubWeight™ 41244.80‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 Basic local alignment search tool. 1990 659.07
2 Detection of specific sequences among DNA fragments separated by gel electrophoresis. 1975 503.08
3 Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. 1977 205.11
4 A general method applicable to the search for similarities in the amino acid sequence of two proteins. 1970 155.96
5 A simple method for displaying the hydropathic character of a protein. 1982 150.65
6 Identification of common molecular subsequences. 1981 130.53
7 Studies on transformation of Escherichia coli with plasmids. 1983 116.81
8 Selective extraction of polyoma DNA from infected mouse cell cultures. 1967 106.91
9 Solvent content of protein crystals. 1968 106.07
10 The Protein Data Bank: a computer-based archival file for macromolecular structures. 1977 90.57
11 A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. 1975 90.35
12 SCOP: a structural classification of proteins database for the investigation of sequences and structures. 1995 74.88
13 A complementation analysis of the restriction and modification of DNA in Escherichia coli. 1969 71.21
14 Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. 2001 66.87
15 Genetic regulatory mechanisms in the synthesis of proteins. 1961 65.10
16 Comparative protein modelling by satisfaction of spatial restraints. 1993 64.61
17 Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. 1980 61.16
18 Prediction of complete gene structures in human genomic DNA. 1997 58.76
19 CV. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. Chemical synthesis of an icosadeoxyribonucleotide corresponding to the nucleotide sequence 31 to 50. 1972 58.52
20 T-Coffee: A novel method for fast and accurate multiple sequence alignment. 2000 57.88
21 Nucleotide and amino acid sequences of gene G of omegaX174. 1976 57.73
22 Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. 1986 55.34
23 Calcium-dependent bacteriophage DNA infection. 1970 53.43
24 Improved prediction of signal peptides: SignalP 3.0. 2004 48.40
25 ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. 1965 46.35
26 Inference of macromolecular assemblies from crystalline state. 2007 44.95
27 Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. 1962 41.99
28 Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. 1999 41.48
29 Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. 1980 41.18
30 The interpretation of protein structures: estimation of static accessibility. 1971 40.24
31 SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA. 1965 36.76
32 Determination of the base composition of deoxyribonucleic acid from its buoyant density in CsCl. 1962 36.74
33 Protein structure comparison by alignment of distance matrices. 1993 34.74
34 Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels. 1977 33.84
35 Maturation of the head of bacteriophage T4. I. DNA packaging events. 1973 33.51
36 Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. 1978 33.47
37 Protein secondary structure prediction based on position-specific scoring matrices. 1999 33.07
38 Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. 1976 33.01
39 A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. 1965 32.99
40 Lambda replacement vectors carrying polylinker sequences. 1983 32.76
41 Hidden Markov models in computational biology. Applications to protein modeling. 1994 31.57
42 Information content of binding sites on nucleotide sequences. 1986 30.48
43 Analysis of bacteriophage T7 early RNAs and proteins on slab gels. 1973 30.17
44 Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli. 1981 29.04
45 A specific endonuclease from Arthrobacter luteus. 1976 25.89
46 Kinetics of renaturation of DNA. 1968 25.41
47 Position-based sequence weights. 1994 24.41
48 Circular DNA forms of colicinogenic factors E1, E2 and E3 from Escherichia coli. 1968 23.73
49 Amino acid substitution matrices from an information theoretic perspective. 1991 23.38
50 CpG islands in vertebrate genomes. 1987 23.16
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