Molecular and cellular biology (Mol Cell Biol)

Journal PubWeight™ 31417.11‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. 1982 116.75
2 High-efficiency transformation of mammalian cells by plasmid DNA. 1987 43.61
3 Firefly luciferase gene: structure and expression in mammalian cells. 1987 26.70
4 Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. 1985 25.52
5 High-efficiency cloning of full-length cDNA. 1982 22.81
6 Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. 1984 20.61
7 A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells. 1983 18.32
8 Correlation between protein and mRNA abundance in yeast. 1999 16.95
9 Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. 1986 16.65
10 Coordinate control of syntheses of ribosomal ribonucleic acid and ribosomal proteins during nutritional shift-up in Saccharomyces cerevisiae. 1981 16.51
11 Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. 1996 15.20
12 Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. 2000 14.74
13 Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques. 1985 13.99
14 Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. 1988 13.78
15 Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. 1988 13.27
16 Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. 1992 12.96
17 SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. 1988 12.84
18 Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. 1987 11.36
19 XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. 2003 11.17
20 Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. 1983 11.06
21 A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. 1992 11.03
22 Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. 2002 10.95
23 Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. 1998 10.34
24 Inhibition of macroautophagy triggers apoptosis. 2005 10.27
25 Transcriptional regulation of hemoglobin switching in chicken embryos. 1981 9.97
26 Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. 2000 9.92
27 Transposable elements: targets for early nutritional effects on epigenetic gene regulation. 2003 9.30
28 Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. 2000 9.21
29 Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. 2001 8.95
30 Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. 2004 8.94
31 Autophagy is activated for cell survival after endoplasmic reticulum stress. 2006 8.89
32 Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. 2000 8.89
33 New procedure for DNA transfection with polycation and dimethyl sulfoxide. 1984 8.63
34 Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. 2002 8.60
35 The polycomb group protein Suz12 is required for embryonic stem cell differentiation. 2007 8.57
36 Exon definition may facilitate splice site selection in RNAs with multiple exons. 1990 8.17
37 c-Myc target genes involved in cell growth, apoptosis, and metabolism. 1999 8.17
38 Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. 2003 8.12
39 Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. 2001 8.03
40 Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process. 1984 7.99
41 Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. 2007 7.97
42 Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG. 1984 7.83
43 Nuclear localization and regulation of erk- and rsk-encoded protein kinases. 1992 7.72
44 A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus. 1985 7.66
45 Identification and characterization of a family of mammalian methyl-CpG binding proteins. 1998 7.61
46 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. 1994 7.53
47 Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. 1985 7.49
48 A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. 1986 7.49
49 Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. 1982 7.49
50 The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. 2002 7.44
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