The EMBO journal (EMBO J)

Journal PubWeight™ 29295.50‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. 1987 57.37
2 LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. 2000 41.48
3 Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. 1982 38.14
4 Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. 1991 23.69
5 MicroRNA genes are transcribed by RNA polymerase II. 2004 20.65
6 Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. 1985 20.39
7 The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression. 1986 19.59
8 MicroRNA maturation: stepwise processing and subcellular localization. 2002 19.47
9 Gene transfer into mouse lyoma cells by electroporation in high electric fields. 1982 17.98
10 Mechanism of activation of protein kinase B by insulin and IGF-1. 1996 16.68
11 The relation between the divergence of sequence and structure in proteins. 1986 16.66
12 beta-catenin is a target for the ubiquitin-proteasome pathway. 1997 12.97
13 Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. 2008 12.89
14 Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. 2001 12.88
15 Selection of AUG initiation codons differs in plants and animals. 1987 12.73
16 Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. 1993 12.38
17 Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. 1991 11.86
18 Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. 2007 11.72
19 Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. 1986 11.41
20 Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. 1993 11.30
21 Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. 2004 11.00
22 Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. 1992 10.97
23 Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. 1989 10.84
24 LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. 2004 10.82
25 Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. 1999 10.82
26 Two CD95 (APO-1/Fas) signaling pathways. 1998 10.42
27 A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. 1984 10.28
28 Recognition of the polyubiquitin proteolytic signal. 2000 10.12
29 HIF-1 alpha is required for solid tumor formation and embryonic vascularization. 1998 10.08
30 The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. 1989 10.05
31 Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. 1998 10.01
32 Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. 1983 10.00
33 Origin and evolution of retroelements based upon their reverse transcriptase sequences. 1990 9.93
34 Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. 1999 9.76
35 Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. 2007 9.65
36 The tripartite motif family identifies cell compartments. 2001 9.64
37 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. 2003 9.55
38 The ErbB signaling network: receptor heterodimerization in development and cancer. 2000 9.51
39 Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. 1998 9.36
40 HIV-1 replication is controlled at the level of T cell activation and proviral integration. 1990 9.34
41 Easy identification of cDNA clones. 1983 9.18
42 A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. 1990 9.17
43 A Tn3 lacZ transposon for the random generation of beta-galactosidase gene fusions: application to the analysis of gene expression in Agrobacterium. 1985 9.03
44 Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. 1992 8.86
45 The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. 2001 8.84
46 The kink-turn: a new RNA secondary structure motif. 2001 8.58
47 Two classes of short interfering RNA in RNA silencing. 2002 8.54
48 Transcriptional control by the TGF-beta/Smad signaling system. 2000 8.49
49 Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure. 1990 8.46
50 Infectious rabies viruses from cloned cDNA. 1994 8.35
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