Nature genetics (Nat Genet)

Journal PubWeight™ 19612.93‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. 2000 336.52
2 Principal components analysis corrects for stratification in genome-wide association studies. 2006 115.71
3 Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. 2001 63.36
4 A framework for variation discovery and genotyping using next-generation DNA sequencing data. 2011 59.36
5 Generalized lacZ expression with the ROSA26 Cre reporter strain. 1999 55.63
6 PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. 2003 53.59
7 Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. 2001 53.16
8 A new multipoint method for genome-wide association studies by imputation of genotypes. 2007 52.68
9 Combinatorial microRNA target predictions. 2005 50.48
10 Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. 1995 49.77
11 Detection of large-scale variation in the human genome. 2004 49.18
12 Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. 2008 43.63
13 dbEST--database for "expressed sequence tags". 1993 41.10
14 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. 2008 35.06
15 Common SNPs explain a large proportion of the heritability for human height. 2010 35.02
16 Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. 2007 32.41
17 Exome sequencing identifies the cause of a mendelian disorder. 2009 32.06
18 Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 2008 30.20
19 High density synthetic oligonucleotide arrays. 1999 29.99
20 GenePattern 2.0. 2006 29.07
21 A high-resolution recombination map of the human genome. 2002 28.66
22 A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. 1996 26.06
23 Prospects for whole-genome linkage disequilibrium mapping of common disease genes. 1999 25.93
24 Newly identified loci that influence lipid concentrations and risk of coronary artery disease. 2008 25.83
25 Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. 2003 25.57
26 Efficiency and power in genetic association studies. 2005 25.56
27 Systematic determination of genetic network architecture. 1999 25.45
28 Population structure, differential bias and genomic control in a large-scale, case-control association study. 2005 25.34
29 Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. 2008 24.51
30 Population genomics of human gene expression. 2007 24.49
31 Fine-scale structural variation of the human genome. 2005 24.31
32 Characterization of single-nucleotide polymorphisms in coding regions of human genes. 1999 24.24
33 Systematic variation in gene expression patterns in human cancer cell lines. 2000 24.22
34 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 2010 23.08
35 A genome-wide association study of global gene expression. 2007 22.98
36 A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. 2007 22.96
37 Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. 1999 22.84
38 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. 2008 22.35
39 Identification of protein coding regions by database similarity search. 1993 21.58
40 Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. 2000 21.52
41 High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. 1998 21.52
42 A molecular signature of metastasis in primary solid tumors. 2002 21.36
43 Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. 2007 21.18
44 A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. 2005 20.97
45 The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. 2006 20.76
46 Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. 2008 20.73
47 Common variants at 30 loci contribute to polygenic dyslipidemia. 2008 20.66
48 High-resolution haplotype structure in the human genome. 2001 20.51
49 Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. 2007 20.22
50 High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi. 2008 19.97
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