Published in Development on March 01, 1999
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags. PLoS Genet (2010) 7.05
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet (2001) 6.56
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46
Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury. Science (2012) 3.45
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell (2011) 3.12
The Wnts. Genome Biol (2001) 2.90
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev (2010) 2.28
Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension. Hum Mol Genet (2014) 2.19
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn (2006) 2.03
WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr Biol (2010) 2.00
Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J (2009) 1.97
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature (2011) 1.91
WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn (2010) 1.91
Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol (2010) 1.83
Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol (2008) 1.82
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell (2006) 1.81
Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A (2000) 1.81
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development (2008) 1.74
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol (2004) 1.72
Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation. J Cell Biochem (2005) 1.69
The role of spatially controlled cell proliferation in limb bud morphogenesis. PLoS Biol (2010) 1.68
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol (2004) 1.68
Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61
Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J Neurosci (2010) 1.57
WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways. Dev Biol (2011) 1.53
Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem (2009) 1.52
Wnt5 signaling in vertebrate pancreas development. BMC Biol (2005) 1.45
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol (2011) 1.44
Microtia: epidemiology and genetics. Am J Med Genet A (2011) 1.42
Wnt5a is essential for intestinal elongation in mice. Dev Biol (2008) 1.41
Wnt signaling and pulmonary fibrosis. Am J Pathol (2003) 1.41
Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41
Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. Hum Mol Genet (2008) 1.39
The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem (2012) 1.39
The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts. Mol Cell Biol (2005) 1.39
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development (2012) 1.37
Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J (2004) 1.37
Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A (2012) 1.36
Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A (2001) 1.35
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev Dyn (2010) 1.33
Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program. Development (2009) 1.31
Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Mol Cell Biol (2011) 1.31
Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation. Dev Biol (2008) 1.28
Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol (2011) 1.27
Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers. Mech Dev (2004) 1.26
Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod (2009) 1.26
Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity. Dev Cell (2011) 1.26
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes Dev (2010) 1.25
3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19). Gene Expr Patterns (2008) 1.24
Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn (2011) 1.24
Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches. Nat Rev Endocrinol (2013) 1.23
Oriented cell motility and division underlie early limb bud morphogenesis. Development (2010) 1.23
Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. Am J Hum Genet (2000) 1.23
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell (2008) 1.23
Wnt signaling in development and disease. Cell Biosci (2012) 1.22
Tissue-specific requirements of beta-catenin in external genitalia development. Development (2008) 1.22
Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron (2009) 1.22
Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet (2009) 1.19
Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Dev Cell (2015) 1.19
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development (2012) 1.19
A role for planar cell polarity signaling in angiogenesis. Angiogenesis (2008) 1.18
Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS One (2011) 1.18
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem (2010) 1.17
Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis. Dev Biol (2007) 1.17
Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep (2007) 1.17
Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Bone (2007) 1.15
Wnt signaling specifies and patterns intestinal endoderm. Mech Dev (2011) 1.14
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One (2008) 1.14
The role of Wnt5a in prostate gland development. Dev Biol (2009) 1.14
Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics. Nat Commun (2010) 1.12
Macrophages and angiogenesis: a role for Wnt signaling. Vasc Cell (2012) 1.12
Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci U S A (2013) 1.12
Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol Endocrinol (2009) 1.12
WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn (2008) 1.11
Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema. PLoS Comput Biol (2013) 1.11
Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol (2013) 1.11
Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11
Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop. Biomaterials (2011) 1.10
How to make an intestine. Development (2014) 1.10
Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med (2007) 1.10
Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium. Gene Expr Patterns (2008) 1.09
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons. J Neurosci (2009) 1.09
Wnt5a and Wnt11 are essential for second heart field progenitor development. Development (2012) 1.08
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum Mol Genet (2010) 1.07
Greglist: a database listing potential G-quadruplex regulated genes. Nucleic Acids Res (2007) 1.07
Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb Perspect Biol (2012) 1.06
Exploring the mechanisms regulating regeneration of deer antlers. Philos Trans R Soc Lond B Biol Sci (2004) 1.05
Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells. Cancer Res (2015) 1.04
Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program. PLoS One (2013) 1.04
The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harb Perspect Biol (2014) 1.03
Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J Cell Biol (2010) 1.03
CATH--a hierarchic classification of protein domain structures. Structure (1997) 29.95
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science (1993) 14.91
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
A physical map of the human genome. Nature (2001) 12.39
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol (1998) 10.58
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development (2001) 9.00
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Fate of the mammalian cardiac neural crest. Development (2000) 6.79
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature (1993) 6.75
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature (1984) 6.54
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01
A functional genomic analysis of cell morphology using RNA interference. J Biol (2003) 5.99
Impaired energy homeostasis in C/EBP alpha knockout mice. Science (1995) 5.68
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Chromosome engineering in mice. Nature (1995) 5.48
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol (1995) 5.36
Acute myocardial infarction: home and hospital treatment. Br Med J (1971) 5.21
Increased bone formation in osteocalcin-deficient mice. Nature (1996) 4.91
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature (1999) 4.74
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature (1986) 4.73
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Sonic hedgehog regulates growth and morphogenesis of the tooth. Development (2000) 4.71
Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41
Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet (1987) 4.20
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17
Female development in mammals is regulated by Wnt-4 signalling. Nature (1999) 4.13
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene (1993) 4.03
The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread. Infect Immun (1995) 4.02
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development (1996) 3.91
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet (1993) 3.85
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev (1995) 3.84
Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature (1991) 3.83
Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev (1994) 3.77
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev (1993) 3.60
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A (1998) 3.60
Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1993) 3.57
Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature (1992) 3.54
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Gene targeting in embryonic stem cells. Methods Enzymol (1993) 3.41
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev (2000) 3.30
Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol (1998) 3.29
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell (1987) 3.29
Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat Genet (2000) 3.28
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity (2001) 3.27
Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol Cell Biol (1991) 3.25
The value of feedback in teaching interviewing skills to medical students. Psychol Med (1978) 3.24
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev (1999) 3.13
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12
Wnt signalling required for expansion of neural crest and CNS progenitors. Nature (1997) 3.11
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A (1999) 3.06
Genomic DNA microextraction: a method to screen numerous samples. Anal Biochem (1992) 3.05
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98
Multiple defects and perinatal death in mice deficient in follistatin. Nature (1995) 2.96
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development (1998) 2.90
Equity, waiting times, and NHS reforms: retrospective study. BMJ (2009) 2.86
Association of alkaline phosphatase with an autoantigen recognised by circulating anti-neutrophil antibodies in systemic vasculitis. Lancet (1987) 2.85
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84
The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature (2000) 2.78
The length of homology required for gene targeting in embryonic stem cells. Mol Cell Biol (1991) 2.75
A comparative evaluation of three accelerometry-based physical activity monitors. Med Sci Sports Exerc (2000) 2.75
A local Wnt-3a signal is required for development of the mammalian hippocampus. Development (2000) 2.75
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature (1995) 2.73
Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development (1994) 2.73
Mouse ENU mutagenesis. Hum Mol Genet (1999) 2.72
Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1998) 2.71
Functional analysis of activins during mammalian development. Nature (1995) 2.71
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
Comparison of effects of a self management booklet and audiocassette for patients with asthma. BMJ (1988) 2.66
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell (2001) 2.65
Tobacco point of sale advertising increases positive brand user imagery. Tob Control (2002) 2.65
The tumor suppressor p53. Biochim Biophys Acta (1993) 2.65
A novel method of applying a split cast. Injury (2005) 2.64
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62
Different phenotypes for mice deficient in either activins or activin receptor type II. Nature (1995) 2.62
Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature (1999) 2.60
Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59
Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J (1993) 2.57