Calreticulin is essential for cardiac development.

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Published in J Cell Biol on March 08, 1999

Authors

N Mesaeli1, K Nakamura, E Zvaritch, P Dickie, E Dziak, K H Krause, M Opas, D H MacLennan, M Michalak

Author Affiliations

1: Medical Research Council Group in Molecular Biology of Membranes, Department of Biochemistry, University of Alberta, Canada.

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Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum. J Biol Chem (1974) 1.89

Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains. J Biol Chem (1991) 1.89

Mutation of aspartic acid-351, lysine-352, and lysine-515 alters the Ca2+ transport activity of the Ca2+-ATPase expressed in COS-1 cells. Proc Natl Acad Sci U S A (1988) 1.89

Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. J Biol Chem (1998) 1.88

The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity (2000) 1.88