Published in Exp Neurol on May 01, 1999
Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Pharmacol Ther (2010) 1.66
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci (2008) 1.54
Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease. Br J Pharmacol (2004) 0.86
Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes. Mol Brain (2010) 0.84
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 64.32
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med (2001) 4.83
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet (1996) 4.77
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science (1984) 4.52
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem (1984) 3.98
Membrane pores induced by magainin. Biochemistry (1996) 3.97
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest (2001) 3.86
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol (2001) 3.74
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet (1992) 3.53
Cloning and characterization of adeno-associated virus type 5. J Virol (1999) 3.36
CYP3A variation and the evolution of salt-sensitivity variants. Am J Hum Genet (2004) 3.32
Role of metals in oxygen radical reactions. J Free Radic Biol Med (1985) 3.22
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature (1998) 3.16
Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05
Human magnetic resonance imaging at 8 T. NMR Biomed (1998) 2.96
Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med (1983) 2.93
Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91
Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence. J Bacteriol (1991) 2.64
Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Ann Neurol (1997) 2.64
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol (1993) 2.56
Oxidative damage in Alzheimer's. Nature (1996) 2.55
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J Biochem (1997) 2.51
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol (1994) 2.43
The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harb Symp Quant Biol (1999) 2.40
Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics (1993) 2.39
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A (2000) 2.30
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature (1986) 2.29
Fatigue testing median sternotomy closures. Eur J Cardiothorac Surg (2001) 2.27
An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet (1995) 2.26
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut (2008) 2.26
Experimental evidence for hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin. Biophys J (1999) 2.23
Selective sparing of a class of striatal neurons in Huntington's disease. Science (1985) 2.16
Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med (1996) 2.14
Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem (1993) 2.06
Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med (2000) 2.04
The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase. Proc Natl Acad Sci U S A (1994) 2.04
Oxidative stress in patients with Friedreich ataxia. Neurology (2000) 2.03
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med (1999) 2.03
Airway protection during experimental CPR. Chest (1995) 1.96
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci (2001) 1.95
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A (1991) 1.93
Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem (1999) 1.91
Huntington aggregates may not predict neuronal death in Huntington's disease. Ann Neurol (1999) 1.91
Quantum confinement and electronic properties of silicon nanowires. Phys Rev Lett (2004) 1.91
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem (1997) 1.90
Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev Dyn (1997) 1.90
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells. J Thromb Haemost (2008) 1.88
Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology (1993) 1.88
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity (1999) 1.88
Record linked retrospective cohort study of 4.6 million people exploring ethnic variations in disease: myocardial infarction in South Asians. BMC Public Health (2007) 1.88
Comparison of microvascular permeability measurements, K(trans), determined with conventional steady-state T1-weighted and first-pass T2*-weighted MR imaging methods in gliomas and meningiomas. AJNR Am J Neuroradiol (2006) 1.87
Postoperative depression of tumour-directed cell-mediated immunity in patients with malignant disease. Br Med J (1972) 1.84
Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat Biotechnol (2000) 1.84
Computational drug repositioning: from data to therapeutics. Clin Pharmacol Ther (2013) 1.82
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci U S A (1998) 1.81
Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci U S A (1997) 1.80
Oxidative stress in Huntington's disease. Brain Pathol (1999) 1.80
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci (2000) 1.79
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med (1999) 1.79
Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann Neurol (2001) 1.77
Structure of the red fluorescence band in chloroplasts. J Gen Physiol (1966) 1.77
Theoretical analysis of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin. Biophys J (1999) 1.77
Assessing pollution prevention program by QUAL2E simulation analysis for the Kao-Ping River Basin, Taiwan. J Environ Manage (2001) 1.77
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology (2006) 1.73
Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem (1994) 1.69
Epinephrine increases the severity of postresuscitation myocardial dysfunction. Circulation (1995) 1.68
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A (1998) 1.68
Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study. Stroke (1998) 1.68
Interferometer-controlled scanning transmission X-ray microscopes at the Advanced Light Source. J Synchrotron Radiat (2003) 1.68
Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol (1999) 1.67
Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway. Infect Immun (1994) 1.66
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci (2001) 1.64
Membrane thinning effect of the beta-sheet antimicrobial protegrin. Biochemistry (2000) 1.64
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study. Neurology (1996) 1.60
Short duration of sleep and unintentional injuries among adolescents in China. Am J Epidemiol (2007) 1.58
Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol (1998) 1.58
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis (2001) 1.57
Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science (1994) 1.57
In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin. Cell (1985) 1.57
Characterization of the hgbA locus encoding a hemoglobin receptor from Haemophilus ducreyi. Infect Immun (1995) 1.56
Regional differences in the prevalence of known Type 2 diabetes mellitus in 45-74 years old individuals: results from six population-based studies in Germany (DIAB-CORE Consortium). Diabet Med (2012) 1.56
Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med (1997) 1.56
Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab (1999) 1.56
Mutans streptococci dose response to xylitol chewing gum. J Dent Res (2006) 1.55
Matrix metalloproteinase-9 may be a potential therapeutic target in epilepsy. Med Hypotheses (2011) 1.54
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neural Transm Suppl (2000) 1.54
Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells. Cancer Res (1985) 1.53
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol (1997) 1.53
Design and assembly of an 8 tesla whole-body MR scanner. J Comput Assist Tomogr (1999) 1.52
Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci (1998) 1.52