Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

PubWeight™: 3.58‹?› | Rank: Top 1%

🔗 View Article (PMID 10319819)

Published in Cell on April 30, 1999

Authors

F G Gervais1, D Xu, G S Robertson, J P Vaillancourt, Y Zhu, J Huang, A LeBlanc, D Smith, M Rigby, M S Shearman, E E Clarke, H Zheng, L H Van Der Ploeg, S C Ruffolo, N A Thornberry, S Xanthoudakis, R J Zamboni, S Roy, D W Nicholson

Author Affiliations

1: Department of Pharmacology, Biochemistry, and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Kirkland, Quebec, Canada.

Articles citing this

(truncated to the top 100)

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol (2000) 3.97

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 3.85

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci (2010) 2.99

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc Natl Acad Sci U S A (2004) 2.88

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80

Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J (2000) 2.58

Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev (2000) 2.48

Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci (2011) 2.47

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci U S A (2006) 2.45

Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease? Nat Rev Neurosci (2010) 2.34

Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease. Am J Pathol (2004) 2.19

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron (2010) 2.10

APP processing in Alzheimer's disease. Mol Brain (2011) 2.02

Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging (2008) 1.89

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am J Pathol (1999) 1.71

Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma. Am J Pathol (2004) 1.63

Role of apoptosis in disease. Aging (Albany NY) (2012) 1.58

Synapses and Alzheimer's disease. Cold Spring Harb Perspect Biol (2012) 1.57

Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J Biol Chem (2004) 1.55

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability. Proc Natl Acad Sci U S A (2007) 1.49

Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol (2008) 1.47

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing. PLoS One (2015) 1.47

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Proc Natl Acad Sci U S A (2004) 1.46

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci (2010) 1.44

Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci (2008) 1.44

Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). FASEB J (2006) 1.35

Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol (2001) 1.35

Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. J Biol Chem (2008) 1.35

The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem (2008) 1.31

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo. EMBO J (2006) 1.29

S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein. Mol Cell Biol (2001) 1.29

Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. J Biol Chem (2005) 1.25

Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22

Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxid Redox Signal (2013) 1.20

Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol (2006) 1.20

Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β. Protein Cell (2010) 1.19

Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels. Anesthesiology (2009) 1.17

Cystatin C protects neuronal cells from amyloid-beta-induced toxicity. J Alzheimers Dis (2010) 1.17

Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease. Brain Res (2008) 1.16

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. Hum Mol Genet (2012) 1.16

Survival motor neuron protein modulates neuron-specific apoptosis. Proc Natl Acad Sci U S A (2000) 1.14

Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases. Pharmaceuticals (Basel) (2010) 1.13

The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains. Mol Neurodegener (2009) 1.12

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener (2009) 1.12

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res (2008) 1.12

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. J Biol Chem (2011) 1.11

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. J Neurosci (2010) 1.10

Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. J Neuropathol Exp Neurol (2009) 1.09

Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies. Proc Natl Acad Sci U S A (2005) 1.08

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc Natl Acad Sci U S A (2002) 1.07

Molecular mechanisms of cognitive dysfunction following traumatic brain injury. Front Aging Neurosci (2013) 1.05

Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? Int J Physiol Pathophysiol Pharmacol (2009) 1.03

Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells. J Neuroinflammation (2012) 1.03

Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol (2004) 1.00

Redox regulation of the intrinsic pathway in neuronal apoptosis. Antioxid Redox Signal (2011) 1.00

Apoptosis and in vitro Alzheimer disease neuronal models. Commun Integr Biol (2009) 1.00

Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC Neurosci (2005) 0.98

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol (2014) 0.98

Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol (2011) 0.97

Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Struct Funct (2009) 0.97

Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? Int J Clin Exp Pathol (2008) 0.97

Lens defects and age-related fiber cell degeneration in a mouse model of increased AbetaPP gene dosage in Down syndrome. Am J Pathol (2002) 0.96

Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content. J Cell Mol Med (2008) 0.96

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures. Cell Death Dis (2010) 0.96

Structure and pathology of tau protein in Alzheimer disease. Int J Alzheimers Dis (2012) 0.96

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease. Front Aging Neurosci (2013) 0.94

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res (2009) 0.94

C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis (2008) 0.93

The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32. Proc Natl Acad Sci U S A (2000) 0.92

In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin. Neurotoxicology (2011) 0.92

HSV-1 and Alzheimer's disease: more than a hypothesis. Front Pharmacol (2014) 0.91

Lack of glutathione peroxidase-1 exacerbates Abeta-mediated neurotoxicity in cortical neurons. J Neural Transm (Vienna) (2005) 0.90

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment. J Neurosci (2012) 0.90

A portrait of the Bcl-2 protein family: life, death, and the whole picture. J Clin Immunol (1999) 0.90

Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease. Biol Psychiatry (2014) 0.90

Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease. J Neurosci (2012) 0.90

Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis (2010) 0.90

Caspase-6 activity predicts lower episodic memory ability in aged individuals. Neurobiol Aging (2013) 0.90

The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease. Oxid Med Cell Longev (2013) 0.89

Caspases as therapeutic targets. J Cell Mol Med (2008) 0.89

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun (2009) 0.89

A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor. J Alzheimers Dis (2009) 0.88

Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis. Biochim Biophys Acta (2006) 0.87

Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. J Biomed Biotechnol (2006) 0.86

mRNA expression and hypermethylation of tumor suppressor genes apoptosis protease activating factor-1 and death-associated protein kinase in oral squamous cell carcinoma. Oncol Lett (2013) 0.86

Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease. Am J Pathol (2010) 0.85

APP Receptor? To Be or Not To Be. Trends Pharmacol Sci (2016) 0.85

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site. Biochem J (2005) 0.85

Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. Eur J Neurosci (2014) 0.85

Immunoelectron microscopic and biochemical studies of caspase-cleaved tau in a mouse model of tauopathy. J Neuropathol Exp Neurol (2011) 0.85

Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy. PLoS Genet (2015) 0.85

Activation of caspases in intestinal villus epithelial cells of normal and nematode infected rats. Gut (2002) 0.84

Alzheimer's disease: amino acid levels and brain metabolic status. Neurol Sci (2013) 0.84

Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells. J Neural Transm (Vienna) (2011) 0.83

Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis (2007) 0.83

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS One (2012) 0.83

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease. Mol Neurodegener (2011) 0.83

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. Cell Death Differ (2014) 0.82

Articles by these authors

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95

Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng (2001) 20.65

Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science (1998) 19.40

Integrating functional genomic information into the Saccharomyces genome database. Nucleic Acids Res (2000) 18.52

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (1995) 15.07

Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Res (1999) 13.65

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature (1999) 12.95

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem (1997) 9.97

The Complex Carbohydrate Structure Database. Trends Biochem Sci (1989) 9.00

The Mouse Genome Database (MGD): integrating biology with the genome. Nucleic Acids Res (2004) 8.91

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med (2000) 8.89

A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54

The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology. Nucleic Acids Res (2005) 8.19

Oral lesions in sheep and cattle in Dumfries and Galloway. Vet Rec (2001) 7.78

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J (1998) 7.39

Human ICE/CED-3 protease nomenclature. Cell (1996) 7.11

Caspases: killer proteases. Trends Biochem Sci (1997) 7.07

A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study. JAMA (1998) 7.00

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (1995) 6.20

Epitaxial BiFeO3 multiferroic thin film heterostructures. Science (2003) 6.14

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86

Climate change. Recent reductions in China's greenhouse gas emissions. Science (2001) 5.77

Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics (1985) 5.75

Comparisons of highly virulent H5N1 influenza A viruses isolated from humans and chickens from Hong Kong. J Virol (1998) 5.48

A receptor in pituitary and hypothalamus that functions in growth hormone release. Science (1996) 5.45

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity (1996) 5.45

Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon. J Virol (2000) 5.44

Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res (1985) 5.22

The extent of Down's syndrome screening in Britain in 1991. Lancet (1992) 5.20

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev (1997) 5.13

Maternal serum screening for Down's syndrome: the effect of routine ultrasound scan determination of gestational age and adjustment for maternal weight. Br J Obstet Gynaecol (1992) 5.11

Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell (2000) 5.08

Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes. Proc Natl Acad Sci U S A (2001) 4.93

Control of acid resistance in Escherichia coli. J Bacteriol (1999) 4.93

The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proc Natl Acad Sci U S A (2000) 4.82

Identification of multiple cyclin subunits of human P-TEFb. Genes Dev (1998) 4.73

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature (1986) 4.70

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol (1998) 4.61

Altruism and social cheating in the social amoeba Dictyostelium discoideum. Nature (2001) 4.60

Voxel-based morphometry using the RAVENS maps: methods and validation using simulated longitudinal atrophy. Neuroimage (2001) 4.58

Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev (2001) 4.47

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science (1992) 4.42

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42

A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol (2001) 4.39

Single-molecule studies of DNA mechanics. Curr Opin Struct Biol (2000) 4.39

Breast cancer in young women and use of oral contraceptives: possible modifying effect of formulation and age at use. Lancet (1983) 4.38

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest (1987) 4.26

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature (2000) 4.12

Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell (1999) 4.07

Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04

Inactivity produces increases in neurotransmitter release and synapse size. Neuron (2001) 4.04

Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med (2001) 3.97

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach. Proc Natl Acad Sci U S A (2000) 3.95

Analysis of yeast protein kinases using protein chips. Nat Genet (2000) 3.94

Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid. Science (1998) 3.81

Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem (1998) 3.80

Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization. International Committee on Virus Taxonomy. Arch Virol (1998) 3.77

APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science (1997) 3.73

Groundwater arsenic contamination in Bangladesh and West Bengal, India. Environ Health Perspect (2000) 3.72

Mitochondrial protein import. Biochim Biophys Acta (1989) 3.66

Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol (1997) 3.62

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature (1995) 3.59

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol (2000) 3.58

Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect (1998) 3.51

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Assessment of commercial laboratories performing hair mineral analysis. JAMA (2001) 3.42

Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. N Engl J Med (1992) 3.41

Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol (2004) 3.37

Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron (1999) 3.28

Effect of allelic heterogeneity on the power of the transmission disequilibrium test. Genet Epidemiol (2000) 3.24

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23

Structured training and assessment in ERCP has become essential for the Calman era. Gut (1999) 3.22

Hydrophobic basis of packing in globular proteins. Proc Natl Acad Sci U S A (1980) 3.19

Mapping the Burkholderia cenocepacia niche response via high-throughput sequencing. Proc Natl Acad Sci U S A (2009) 3.16

Characterization of the surface proteins of influenza A (H5N1) viruses isolated from humans in 1997-1998. Virology (1999) 3.16

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med (1996) 3.16

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14

Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc Natl Acad Sci U S A (2001) 3.12

Temperate Bacteriophage Which Causes the Production of a New Major Outer Membrane Protein by Escherichia coli. J Virol (1975) 3.11

An extremely luminous panchromatic outburst from the nucleus of a distant galaxy. Science (2011) 3.09

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet (1996) 3.08

Genomic DNA microextraction: a method to screen numerous samples. Anal Biochem (1992) 3.05

Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia (2008) 3.04

Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin's lymphoma associated with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group. N Engl J Med (1997) 3.03

Characterization of the cell-wall polysaccharides of Arabidopsis thaliana leaves. Plant Physiol (1995) 3.03

Participation by women in behavior analysis. Behav Anal (1983) 2.95

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc Natl Acad Sci U S A (1998) 2.93