Published in Nature on December 02, 1976
Phorbol diester receptor copurifies with protein kinase C. Proc Natl Acad Sci U S A (1983) 6.25
Specific binding of phorbol ester tumor promoters. Proc Natl Acad Sci U S A (1980) 3.07
Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci U S A (1977) 2.83
A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells. J Cell Biol (1984) 2.46
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Mol Cell Biol (1984) 2.28
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion. Proc Natl Acad Sci U S A (1980) 1.94
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes. Proc Natl Acad Sci U S A (1984) 1.39
Specific binding of phorbol ester tumor promoters to intact primary epidermal cells from Sencar mice. Proc Natl Acad Sci U S A (1981) 1.26
Tumor-promoting phorbol esters inhibit procollagen synthesis at a pretranslational level in JB-6 mouse epidermal cells. Mol Cell Biol (1983) 1.00
Retinoids and phorbol esters alter release of fibronectin from enucleated cells. Proc Natl Acad Sci U S A (1982) 0.99
Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters. J Clin Invest (1981) 0.90
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells. Proc Natl Acad Sci U S A (1982) 0.89
Human papillomavirus type 16 E7 oncoprotein represses transcription of human fibronectin. J Virol (2000) 0.84
Control of differentiation of a mammary cell line by lipids. Proc Natl Acad Sci U S A (1980) 0.83
Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate. Proc Natl Acad Sci U S A (1978) 0.82
PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter. Environ Health Perspect (1981) 0.80
Tumor promoters alter the temporal program of adenovirus replication in human cells. Mol Cell Biol (1981) 0.77
Enhancement of sister-chromatid exchanges by tumour promoters. Br J Cancer (1982) 0.75
Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. Proc Natl Acad Sci U S A (1980) 0.75
Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes. Bacteriol Rev (1974) 7.49
Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev (1999) 7.20
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16
Mechanism of action and development of resistance to a new amidino penicillin. J Bacteriol (1974) 5.47
Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli. J Biol Chem (1972) 3.32
Penicillin-sensitive enzymes and penicillin-binding components in bacterial cells. Ann N Y Acad Sci (1974) 3.16
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell (1995) 3.08
Specific binding of phorbol ester tumor promoters. Proc Natl Acad Sci U S A (1980) 3.07
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci U S A (2000) 2.87
Five penicillin-binding components occur in Bacillus subtilis membranes. J Biol Chem (1972) 2.81
Inactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis. Proc Natl Acad Sci U S A (1971) 2.80
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem (1993) 2.62
Regulation of cell apoptosis by protein kinase c delta. Apoptosis (2003) 2.60
Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem (2001) 2.55
RasGRP links T-cell receptor signaling to Ras. Blood (2000) 2.46
Isolation by covalent affinity chromatography of the penicillin-binding components from membranes of Bacillus subtilis. Proc Natl Acad Sci U S A (1972) 2.28
Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth. Proc Natl Acad Sci U S A (1979) 2.28
Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. Proc Natl Acad Sci U S A (1983) 2.23
How penicillin kills bacteria: progress and problems. Proc R Soc Lond B Biol Sci (1971) 2.21
The effect of phorbol diesters on chicken embryo fibroblasts. Cancer Res (1977) 2.14
Taxonomy and function of C1 protein kinase C homology domains. Protein Sci (1997) 1.98
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience (1989) 1.94
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem (1992) 1.80
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Crit Rev Toxicol (1980) 1.73
Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product. Mol Cell Biol (1987) 1.63
Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc Natl Acad Sci U S A (1984) 1.60
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. J Biol Chem (2000) 1.59
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem (1994) 1.55
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta. J Biol Chem (1993) 1.51
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol (1999) 1.51
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products. J Biol Chem (1994) 1.49
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A (1988) 1.49
Mechanism of action of the phorbol ester tumor promoters: specific receptors for lipophilic ligands. Biochem Pharmacol (1984) 1.46
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis (1987) 1.44
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol (1993) 1.40
Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proc Natl Acad Sci U S A (1986) 1.39
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2. Crit Rev Toxicol (1981) 1.38
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J Biol Chem (1999) 1.36
Specific binding of phorbol ester tumor promoters to mouse skin. Cell (1980) 1.34
Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis. J Biol Chem (1995) 1.33
Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation. J Neurosci (2001) 1.32
Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res (1995) 1.32
Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action. Biochem Pharmacol (1988) 1.30
Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res (2001) 1.30
Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res (1988) 1.28
Penicillin binding components of bacterial cells and their relationship to the mechanism of penicillin action. Ann N Y Acad Sci (1974) 1.27
Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. J Biol Chem (2000) 1.26
Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C. J Clin Invest (1985) 1.25
Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res (1990) 1.25
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. Mol Pharmacol (2000) 1.24
Effect of proteases on activation of resting chick embryo fibroblasts and on cell surface proteins. Cell (1975) 1.24
Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res (2001) 1.24
Characterization of functional vanilloid receptors expressed by mast cells. Blood (1998) 1.21
Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry (1996) 1.20
Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells. J Biol Chem (1996) 1.20
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res (1993) 1.20
Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain (1996) 1.20
The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Mol Pharmacol (1999) 1.19
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc Natl Acad Sci U S A (1999) 1.19
Kinetics and subcellular localization of specific [3H]phorbol 12, 13-dibutyrate binding by mouse brain. Cancer Res (1981) 1.18
Decrease in collagen production in normal and Rous sarcoma virus-transformed chick embryo fibroblasts induced by phorbol myristate acetate. Cancer Res (1979) 1.15
Binding of (14C)penicillin G to the membrane-bound and the purified D-alanine carboxypeptidases from Bacillus stearothermophilus and Bacillus subtilis and its release. J Biol Chem (1974) 1.15
Purification and characterization of the thermophilic D-alanine carboxypeptidase from membranes of Bacillus stearothermophilus. J Biol Chem (1974) 1.14
Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3. J Immunol (1997) 1.13
Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J Biol Chem (1993) 1.12
Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations. Life Sci (1996) 1.10
D-alanine carboxypeptidase and cell wall cross-linking in Bacillus subtilis. J Bacteriol (1974) 1.09
Covalent affinity chromatography of penicillin-binding components from bacterial membranes. Methods Enzymol (1974) 1.08
Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol ester. Proc Natl Acad Sci U S A (1983) 1.07
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci (1990) 1.07
Characterization of specific binding of [3H]phorbol 12,13-dibutyrate and [3H]phorbol 12-myristate 13-acetate to mouse brain. Cancer Res (1980) 1.06
Relation of human neutrophil phorbol ester receptor occupancy and NADPH-oxidase activity. Blood (1982) 1.06
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol (1994) 1.05
Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog. Brain Res (1989) 1.04
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. Mol Pharmacol (1994) 1.04
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. Cancer Res (1987) 1.04
Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ (1995) 1.04
Inhibition of the Bacillus subtilis membrane-bound D-alanine carboxypeptidase by 6-aminopenicillanic acid covalently coupled to sepharose. J Bacteriol (1974) 1.03
Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors. J Biol Chem (1994) 1.03
Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J Pharmacol Exp Ther (1990) 1.03
Phosphorylation of the gamma chain of the high affinity receptor for immunoglobulin E by receptor-associated protein kinase C-delta. J Biol Chem (1994) 1.03
Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18. J Nat Prod (1996) 1.03
Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells. Cancer Res (1988) 1.03
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein. J Biol Chem (2000) 1.03
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1. Br J Pharmacol (1999) 1.02
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. Biochem Biophys Res Commun (1995) 1.02
Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun. Proc Natl Acad Sci U S A (1994) 1.02
Specific binding of [20-3H]12-deoxyphorbol 13-isobutyrate to phorbol ester receptor subclasses in mouse skin particulate preparations. Cancer Res (1983) 1.02
Differential activation and desensitization of sensory neurons by resiniferatoxin. J Neurosci (1997) 1.01
Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells. Cancer Res (1981) 1.01
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C? J Med Chem (2000) 1.01
Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J Biol Chem (1997) 1.01
Quantitative correlation between in vitro and in vivo activities of phorbol esters. Cancer Res (1979) 1.01