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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 1997 8.81
2 Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 1995 4.39
3 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol 1998 4.13
4 Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 1997 3.90
5 Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem 1997 3.86
6 A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 1999 3.21
7 Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol 1999 2.74
8 Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol 1999 1.98
9 p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol Cell Biol 1999 1.73
10 Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. J Biol Chem 1999 1.72
11 A complication of pectus excavatum operation: endomyocardial steel strut. Ann Thorac Surg 1999 1.57
12 Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A 1997 1.57
13 Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 1995 1.57
14 The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem 1997 1.47
15 Kinase and neurotransmitters. Nature 1990 1.40
16 The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. J Biol Chem 2001 1.36
17 PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol 1999 1.31
18 Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. J Biol Chem 1995 1.23
19 D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem 1996 1.19
20 Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. J Biol Chem 1995 1.14
21 Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem 1998 1.11
22 The lipid products of phosphoinositide 3-kinase contribute to regulation of cholangiocyte ATP and chloride transport. J Biol Chem 1999 1.06
23 Clinical experience of surgical therapy in 207 patients with thoracic hydatidosis over a 12-year-period. Swiss Med Wkly 2002 1.03
24 Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. Am J Physiol 1997 1.03
25 PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Curr Biol 2000 0.95
26 Mechanisms of cold-induced platelet actin assembly. J Biol Chem 2001 0.94
27 An unusual pure cystic posterior mediastinal mass: a textiloma. Clin Radiol 2008 0.90
28 Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I. FEBS Lett 1998 0.89
29 Bronchogenic cyst invading right atrium in a 5-year-old. Thorac Cardiovasc Surg 2008 0.87
30 Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils. J Immunol 2001 0.84
31 Placental tissue cyclo-oxygenase 1 and 2 in pre-eclamptic and normal pregnancy. Int J Gynaecol Obstet 2006 0.83
32 Isokinetic muscle strength after thoracotomy: standard vs. muscle-sparing posterolateral thoracotomy. Thorac Cardiovasc Surg 2010 0.83
33 Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophils. J Immunol 2001 0.81
34 Treatment of a benign tracheoesophageal fistula in a ventilator dependent quadriplegic patient. Thorac Cardiovasc Surg 2006 0.80
35 Effects of thoracic epidural anaesthesia on pulmonary venous admixture and oxygenation during one-lung ventilation. Acta Anaesthesiol Scand 2007 0.79
36 Rocuronium and sugammadex in patients with myasthenia gravis undergoing thymectomy. Acta Anaesthesiol Scand 2013 0.78
37 The role of specific isoforms of 14-3-3 protein in regulating protein kinase activity in the brain. Biochem Soc Trans 1992 0.78
38 Inhibition of phosphoinositide 3-kinase impairs pre-commitment cell cycle traverse and prevents differentiation in erythroleukaemia cells. Cell Death Differ 2000 0.77
39 The association of total sialic acid and malondialdehyde levels with metabolic and anthropometric variables in obesity. Biotech Histochem 2014 0.77
40 The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity. Biotech Histochem 2014 0.77
41 Platelet protein phosphorylation and protein kinase C activation by phorbol esters with different biological activity and a novel synergistic response with Ca2+ ionophore. Eur J Biochem 1990 0.77
42 Stimulation of an insulin receptor activates and down-regulates the Ca2+-independent protein kinase C, Apl II, through a Wortmannin-sensitive signaling pathway in Aplysia. J Neurochem 1996 0.76
43 Physiological exclusion for massive hemoptysis: when? Eur J Cardiothorac Surg 2001 0.75
44 Pleural tent after upper lobectomy: routine or selective? Ann Thorac Surg 2001 0.75
45 Aortobronchial fistula after coarctation repair. Ann Thorac Surg 2000 0.75
46 Conference discussion: Does a relationship exist between the number of thoracoscopic thymectomies performed and the learning curve for thoracoscopic resection of thymoma in patients with myasthenia gravis? Interact Cardiovasc Thorac Surg 2011 0.75
47 The effects of prostacyclin analogue ZK 36374 and thromboxane synthetase inhibitor UK 38485 on mesenteric ischemia in guinea pigs. Prostaglandins Leukot Essent Fatty Acids 1990 0.75
48 [Determination of antibody levels against coxsackie B virus type 2 and type 3 in sera from blood donors using the microneutralization test]. Mikrobiyol Bul 1989 0.75
49 Extra-anatomic ascending-to-descending aortic bypass via right thoracotomy for complex re-coarctation of the aorta. An alternative surgical approach for complex re-coarctation. Acta Chir Belg 2006 0.75
50 Functions of the p21-activated protein kinases (Paks) in neutrophils and their regulation by complex lipids. Adv Exp Med Biol 1999 0.75
51 Resection of the tracheal carina in an eight-year-old child: a case report. Thorac Cardiovasc Surg 2005 0.75
52 Isolated lung perfusion with Paclitaxel and docetaxel: comparison of the early effects on pulmonary physiology. Thorac Cardiovasc Surg 2007 0.75
53 Radiologic diagnosis of a type-III pleuropulmonary blastoma. JBR-BTR 2015 0.75
54 [Respiratory syncytial virus antibody levels in the 13-25 age group of healthy people using a microneutralization test]. Mikrobiyol Bul 1989 0.75
55 [A comparison of the effects of 50 % oxygen combined with CPAP to the non-ventilated lung vs. 100 % oxygen on oxygenation during one-lung ventilation]. Anasthesiol Intensivmed Notfallmed Schmerzther 2004 0.75
56 Investigations on the occurrence and impact of bovine viral diarrhea (BVD) virus infections in sheep in Turkey. Dtsch Tierarztl Wochenschr 1987 0.75
57 Malignant phaeochromocytoma with cavoatrial extension: transcaval removal of tumor without cardiopulmonary bypass A case report. Minerva Chir 2010 0.75
58 A seroepidemiologic study of bovine respiratory syncytial virus (BRSV) in Turkey. Dtsch Tierarztl Wochenschr 1990 0.75