The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica.

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Published in Mol Microbiol on June 01, 1999

Authors

J Tovar1, A Fischer, C G Clark

Author Affiliations

1: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. j.tovar@rhbnc.ac.uk

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Partial albinism with immunodeficiency (Griscelli syndrome). J Pediatr (1994) 1.42

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