Published in Proc Natl Acad Sci U S A on June 22, 1999
Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev (2012) 2.92
The role of polyomaviruses in human disease. Virology (2008) 2.41
Simian virus 40 infection of humans. J Virol (2003) 1.71
Potential transmission of human polyomaviruses through the gastrointestinal tract after exposure to virions or viral DNA. J Virol (2001) 1.69
JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut (2008) 1.59
Pathogenesis of progressive multifocal leukoencephalopathy--revisited. J Infect Dis (2011) 1.43
Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. J Virol (2001) 1.36
JC virus: an oncogenic virus in animals and humans? Semin Cancer Biol (2009) 1.28
Frequent detection of polyomaviruses in stool samples from hospitalized children. J Infect Dis (2005) 1.25
How many mutations does it take to make a tumor? Proc Natl Acad Sci U S A (1999) 1.20
Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial cells. J Virol (2001) 1.20
Infectious agents and colorectal cancer: a review of Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirus. Cancer Epidemiol Biomarkers Prev (2008) 1.18
Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome. J Virol (2004) 1.13
Immunoglobulin G, A, and M responses to BK virus in renal transplantation. Clin Vaccine Immunol (2006) 1.12
The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer. Proc Natl Acad Sci U S A (2004) 1.09
Gastrointestinal malignancy and the microbiome. Gastroenterology (2014) 1.07
Infection, inflammation, and gastrointestinal cancer. Gut (2005) 1.07
Polyomavirus shedding in the stool of healthy adults. J Clin Microbiol (2009) 1.03
JC virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer (2008) 1.03
The role of viral and bacterial pathogens in gastrointestinal cancer. J Cell Physiol (2008) 1.02
Potential mechanisms of the human polyomavirus JC in neural oncogenesis. J Neuropathol Exp Neurol (2008) 0.98
Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating disease. Acta Neuropathol (2010) 0.98
JC virus mediates invasion and migration in colorectal metastasis. PLoS One (2009) 0.97
Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer. World J Gastroenterol (2007) 0.96
Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies. Clin Microbiol Infect (2011) 0.96
Members of the AP-1 family, c-Jun and c-Fos, functionally interact with JC virus early regulatory protein large T antigen. J Virol (2003) 0.96
Promoter methylation in the genesis of gastrointestinal cancer. Yonsei Med J (2009) 0.93
Prospective study of JC virus seroreactivity and the development of colorectal cancers and adenomas. Cancer Epidemiol Biomarkers Prev (2009) 0.92
JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process? Virol J (2010) 0.86
Significance of infectious agents in colorectal cancer development. J Cancer (2013) 0.85
Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-catenin in colon cancer. PLoS One (2014) 0.85
JC [corrected] virus detection in human tissue specimens. J Clin Pathol (2007) 0.85
JC virus infection in colorectal neoplasia that develops after liver transplantation. Clin Cancer Res (2008) 0.85
JC virus and human colon carcinoma: an intriguing and inconclusive association. Gastroenterology (2003) 0.84
John Cunningham virus T-antigen expression in anal carcinoma. Cancer (2010) 0.83
The molecular biology of gastrointestinal cancer: implications for diagnosis and therapy. Gastrointest Endosc Clin N Am (2008) 0.82
Chromosomal instability and cancer: not just one CINgle mechanism. Gut (2009) 0.82
Detection of human polyomavirus proteins, T-antigen and agnoprotein, in human tumor tissue arrays. J Med Virol (2010) 0.82
Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model. Oncol Rep (2013) 0.81
Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen. World J Gastroenterol (2009) 0.80
Prevalence of JC virus in Chinese patients with colorectal cancer. PLoS One (2012) 0.80
Presence of JC virus DNA in the tumor tissue and normal mucosa of patients with sporadic colorectal cancer (CRC) or with positive family history and Bethesda criteria. Dig Dis Sci (2011) 0.79
JC Virus, Helicobacter pylori, and oesophageal achalasia: preliminary results from a retrospective case-control study. Dig Dis Sci (2012) 0.78
Convicting a human tumor virus: guilt by association? Proc Natl Acad Sci U S A (1999) 0.78
MicroRNA miR-J1-5p as a potential biomarker for JC virus infection in the gastrointestinal tract. PLoS One (2014) 0.77
JC virus infection: a cause of colorectal cancer? J Clin Gastroenterol (2010) 0.77
Systematic analysis of human oncogenic viruses in colon cancer revealed EBV latency in lymphoid infiltrates. Infect Agent Cancer (2014) 0.76
Immune response to JC virus T antigen in patients with and without colorectal neoplasia. Gut Microbes (2014) 0.75
Human JCV infections as a bio-anthropological marker of the formation of Brazilian Amazonian populations. PLoS One (2012) 0.75
Association between hMLH1 hypermethylation and JC virus (JCV) infection in human colorectal cancer (CRC). Clin Epigenetics (2010) 0.75
Review on the role of the human Polyomavirus JC in the development of tumors. Infect Agent Cancer (2017) 0.75
Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions. Oncol Lett (2016) 0.75
Clement Richard Boland, Jr., MD: a conversation with the editor. Interview by William Clifford Roberts. Proc (Bayl Univ Med Cent) (2004) 0.75
Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals. Cancer Genomics Proteomics (2016) 0.75
JC virus T-Antigen DNA in gastrointestinal mucosa of immunosuppressed patients: a prospective, controlled study. Dig Dis Sci (2009) 0.75
Could JC virus provoke metastasis in colon cancer? World J Gastroenterol (2014) 0.75
Molecular prevalence of JC virus in Tehran, Iran. Gastroenterol Hepatol Bed Bench (2012) 0.75
Genetic instability in colorectal cancers. Nature (1997) 12.51
THE CYCLIC HELIX AND CYCLIC COIL FORMS OF POLYOMA VIRAL DNA. Proc Natl Acad Sci U S A (1963) 11.10
Determination of the number of superhelical turns in simian virus 40 DNA by gel electrophoresis. Proc Natl Acad Sci U S A (1975) 8.75
Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes. Science (1993) 8.49
Human polyomavirus JC virus genome. J Virol (1984) 5.87
Structure and function of simian virus 40 large tumor antigen. Annu Rev Biochem (1992) 4.84
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev (1992) 3.32
Cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst (1999) 3.20
Human papovavirus (JC): induction of brain tumors in hamsters. Science (1973) 3.05
The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell (1989) 2.98
JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. J Virol (1996) 2.60
Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol (1998) 2.43
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol (1990) 2.40
DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med (1992) 2.28
Simian virus 40-like DNA sequences in human pleural mesothelioma. Oncogene (1994) 2.21
SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals. Cancer Res (1996) 2.17
New human papovaviruses. Prog Med Virol (1976) 2.14
Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol (1992) 2.07
Simian virus-40 large-T antigen binds p53 in human mesotheliomas. Nat Med (1997) 2.01
Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med (1995) 1.91
Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody prevalence among remote peoples of the world. Am J Epidemiol (1975) 1.76
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas. Nat Med (1997) 1.69
Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus). Science (1978) 1.60
Prevalence rate and age of acquisition of antibodies against JC virus and BK virus in human sera. Microbiol Immunol (1982) 1.56
Distribution of nonintegrated DNA from JC papovavirus in organs of patients with progressive multifocal leukoencephalopathy. J Infect Dis (1983) 1.44
Simian virus 40 and pleural mesothelioma in humans. Cancer Epidemiol Biomarkers Prev (1996) 1.38
Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. Virology (1995) 1.37
Transformation of primary hamster brain cells with JC virus and its DNA. J Virol (1980) 1.36
SV40-like sequences in human bone tumors. Oncogene (1996) 1.33
Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue. Thorax (1996) 1.22
Hypothesis: "Rogue cell"-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis. Proc Natl Acad Sci U S A (1996) 1.17
Association of polyomaviruses JC, SV40, and BK with human brain tumors. Virology (1987) 1.17
Replication activity of JC virus large T antigen phosphorylation and zinc finger domain mutants. J Neurovirol (1996) 1.16
Analysis of human tumors and human malignant cell lines for BK virus-specific DNA sequences. Proc Natl Acad Sci U S A (1978) 1.11
Association of BK virus with human brain tumors and tumors of pancreatic islets. Int J Cancer (1987) 1.06
Latent BK virus infection and Kaposi's sarcoma pathogenesis. Int J Cancer (1996) 1.02
Review: JC virus infection of lymphocytes--revisited. J Infect Dis (1997) 1.01
Evaluation of normal and neoplastic human tissue for BK virus. Virology (1978) 0.93
High titers of antibodies to two human polyomaviruses, JCV and BKV, correlate with increased frequency of chromosomal damage in human lymphocytes. Cancer Lett (1996) 0.90
High incidence of BK virus large-T-antigen-coding sequences in normal human tissues and tumors of different histotypes. Int J Cancer (1995) 0.87
Lack of association of human polyomaviruses with human brain tumors. J Neurooncol (1994) 0.82
An association, in adult Japanese, between the occurrence of rogue cells among cultured lymphocytes (JC virus activity) and the frequency of "simple" chromosomal damage among the lymphocytes of persons exhibiting these rogue cells. Am J Hum Genet (1998) 0.81
New aspects in the pathogenesis of polyomavirus-induced disease. Adv Virus Res (1997) 0.81
The detection of the genetic carriers of hereditary disease. Am J Hum Genet (1949) 15.66
Asian affinities and continental radiation of the four founding Native American mtDNAs. Am J Hum Genet (1993) 6.81
The incidence of consanguineous matings in Japan, with remarks on the estimation of comparative gene frequencies and the expected rate of appearance of induced recessive mutations. Am J Hum Genet (1949) 5.72
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst (1997) 5.68
The Inheritance of Sickle Cell Anemia. Science (1949) 5.26
The genetic structure of a tirbal population, the Vanomama Indians. II. Eleven blood-group systems and the ABH-Le secretor traits. Ann Hum Genet (1972) 4.87
Immune reconstitution inflammatory syndrome in natalizumab-associated PML. Neurology (2011) 4.63
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet (2009) 3.99
Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology (1993) 3.76
The costs of human inbreeding and their implications for variations at the DNA level. Nat Genet (1994) 3.69
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res (1994) 3.63
The genetic structure of a tribal population, the Yanomama Indians. XII. Biodemographic studies. Am J Phys Anthropol (1975) 3.40
Indirect estimates of mutation rates in tribal Amerindians. Proc Natl Acad Sci U S A (1978) 3.36
Conversion of diploidy to haploidy. Nature (2000) 3.28
Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology (1999) 3.06
Establishment of a line of human fetal glial cells that supports JC virus multiplication. Proc Natl Acad Sci U S A (1985) 2.93
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci U S A (1998) 2.89
DNA repair and colorectal cancer. Gastroenterol Clin North Am (1996) 2.88
Regional linguistic and genetic differences among Yanomama indians. Science (1974) 2.87
Mitochondrial DNA "clock" for the Amerinds and its implications for timing their entry into North America. Proc Natl Acad Sci U S A (1994) 2.86
The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis, and proposed use. Am J Hum Genet (1967) 2.81
Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer. Gastroenterology (1992) 2.78
"Private" genetic variants and the frequency of mutation among South American Indians. Proc Natl Acad Sci U S A (1973) 2.64
Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst (1995) 2.62
JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. J Virol (1996) 2.60
The influence of cultural factors on the demography and pattern of gene flow from the Makiritare to the Yanomama Indians. Am J Phys Anthropol (1970) 2.59
Congenital Aniridia. Am J Hum Genet (1960) 2.50
Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol (1998) 2.43
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol (1990) 2.40
Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res (1996) 2.37
Children of incest. Pediatrics (1967) 2.32
Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med (1988) 2.32
Probability of founder effect in a tribal population. Proc Natl Acad Sci U S A (1978) 2.29
The genetic structure of a tribal population, the Yanomama Indians XI. Gene frequencies for 10 blood groups and the ABH-Le secretor traits in the Yanomama and their neighbors; the uniqueness of the tribe. Am J Hum Genet (1975) 2.28
Genetic effects of the atomic bombs: a reappraisal. Science (1981) 2.27
BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer (2003) 2.26
The genetic structure of a tribal population, the Yanomama Indians. XV. Patterns inferred by autocorrelation analysis. Genetics (1986) 2.18
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res (1995) 2.17
Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation. Proc Natl Acad Sci U S A (1982) 2.17
Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a "no-salt" culture. Circulation (1975) 2.17
Allelic disequilibrium and allele frequency distribution as a function of social and demographic history. Am J Hum Genet (1997) 2.14
Population amalgamation and genetic variation: observations on artificially agglomerated tribal populations of Central and South America. Am J Hum Genet (1988) 2.13
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes Dev (2001) 2.11
Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol (1992) 2.07
Founder effect and number of private polymorphisms observed in Amerindian tribes. Proc Natl Acad Sci U S A (1978) 2.06
Description and validation of a method for simultaneous estimation of effective population size and mutation rate from human population data. Proc Natl Acad Sci U S A (1989) 2.02
Lessons from a "primitive" people. Science (1970) 2.01
Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus. Proc Natl Acad Sci U S A (1973) 2.01
Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study. J Clin Oncol (2001) 1.97
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res (1997) 1.96
Rare variants, private polymorphisms, and locus heterozygosity in Amerindian populations. Am J Hum Genet (1978) 1.96
I. Demographic data on two additional villages: Genetic structure of the tribe. Am J Hum Genet (1967) 1.95
Multiple-locus departures from panmictic equilibrium within and between village gene pools of Amerindian tribes at different stages of agglomeration. Genetics (1983) 1.93
Village and tribal genetic distances among American Indians, and the possible implications for human evolution. Proc Natl Acad Sci U S A (1970) 1.92
The detection of increased mutation rates in human populations. Perspect Biol Med (1971) 1.91
Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology (1998) 1.90
Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon. J Biol Chem (1999) 1.90
HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology (1994) 1.86
Microevolution in lower Central America: genetic characterization of the Chibcha-speaking groups of Costa Rica and Panama, and a consensus taxonomy based on genetic and linguistic affinity. Am J Hum Genet (1990) 1.86
The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides. Proc Natl Acad Sci U S A (1986) 1.85
Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS. Neurology (2011) 1.83
Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology (1994) 1.83
Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report. Proc Natl Acad Sci U S A (1980) 1.80
The blood groups and secretor types in five potentially fatal diseases of Caucasian children. Acta Genet Stat Med (1965) 1.78
Gene frequencies and microdifferentiation among the Makiritare Indians. IV. A comparison of a genetic network with ethnohistory and migration matrices; a new index of genetic isolation. Am J Hum Genet (1970) 1.78
The phylogenic relationships of some Indian tribes of Central and South America. Am J Hum Genet (1969) 1.77
Progressive multifocal leukoencephalopathy. Semin Neurol (1999) 1.75
Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res (1996) 1.74
Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science (1996) 1.73
A classification scheme for human polyomavirus JCV variants based on the nucleotide sequence of the noncoding regulatory region. J Neurovirol (2001) 1.72
Gene frequencies and microdifferentiation among the Makiritare Indians. I. Eleven blood group systems and the ABH-Le secretor traits: a note on Rh gene frequency determinations. Am J Hum Genet (1970) 1.72
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res (2001) 1.70
JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology (2000) 1.68
Steady-state regulation of the human DNA mismatch repair system. J Biol Chem (2000) 1.66
HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. J Immunol (1999) 1.63
Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigens. J Virol (1981) 1.63
Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. J Clin Microbiol (2000) 1.63
Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. J Biol Chem (1999) 1.62
Microevolution of the Chibcha-speaking peoples of lower Central America: rare genes in an Amerindian complex. Am J Hum Genet (1992) 1.61
hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. EMBO J (1998) 1.60
Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. Am J Hum Genet (1990) 1.59
JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut (2008) 1.59
The genetic structure of a tribal population, the Yanomama Indians. IX. Gene frequencies for 18 serum protein and erythrocyte enzyme systems in the Yanomama and five neighboring tribes: nine new variants. Am J Hum Genet (1973) 1.59
Multivariate analysis of gametic disequilibrium in the Yanomama. Genetics (1977) 1.57
Further studies on the Xavante Indians. X. Some hypotheses-generalizations resulting from these studies. Am J Hum Genet (1967) 1.55
Our twenty-fifth. Am J Hum Genet (1974) 1.53
Mortality in the children of atomic bomb survivors and controls. Genetics (1974) 1.51
Persistent tubular resistance to aldosterone in infants with congenital hydronephrosis corrected neonatally. J Pediatr (1987) 1.51
Some further observations on the sex ratio among infants born to survivors of the atomic bombings of Hiroshima and Nagasaki. Am J Hum Genet (1966) 1.51
The effects of parental consanguinity and inbreeding in Hirado, Japan. V. Summary and interpretation. Am J Hum Genet (1972) 1.50
Developments in monitoring human populations for mutation rates. Mutat Res (1974) 1.50
Genetic studies on the Ticuna, an enigmatic tribe of Central Amazonas. Ann Hum Genet (1980) 1.49
Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine. J Clin Invest (1996) 1.49