Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects.

PubWeight™: 1.95‹?› | Rank: Top 2%

🔗 View Article (PMC 22120)

Published in Proc Natl Acad Sci U S A on June 22, 1999

Authors

K A Sheikh1, J Sun, Y Liu, H Kawai, T O Crawford, R L Proia, J W Griffin, R L Schnaar

Author Affiliations

1: Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Articles citing this

The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol (2002) 2.08

Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. Proc Natl Acad Sci U S A (2007) 1.84

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci U S A (2001) 1.63

Gangliosides in cell recognition and membrane protein regulation. Curr Opin Struct Biol (2009) 1.57

Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration. Proc Natl Acad Sci U S A (2002) 1.54

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc Natl Acad Sci U S A (2005) 1.43

The role of glycosphingolipid metabolism in the developing brain. J Lipid Res (2008) 1.37

The chemical neurobiology of carbohydrates. Chem Rev (2008) 1.33

Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice. Exp Neurol (2005) 1.32

Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev (2014) 1.32

Brain gangliosides in axon-myelin stability and axon regeneration. FEBS Lett (2009) 1.30

Biosynthesis and degradation of mammalian glycosphingolipids. Philos Trans R Soc Lond B Biol Sci (2003) 1.29

Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res (2010) 1.22

Myelin-associated glycoprotein and its axonal receptors. J Neurosci Res (2009) 1.20

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron (2014) 1.19

Functional roles of glycosphingolipids in signal transduction via lipid rafts. Glycoconj J (2001) 1.16

Traveling for the glycosphingolipid path. Glycoconj J (2001) 1.16

Functional characterization of wild-type and mutant human sialin. EMBO J (2004) 1.16

Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia. Am J Hum Genet (2013) 1.15

Functional roles of gangliosides in neurodevelopment: an overview of recent advances. Neurochem Res (2012) 1.14

Structures, biosynthesis, and functions of gangliosides--an overview. J Oleo Sci (2011) 1.11

Glycosphingolipid functions: insights from engineered mouse models. Philos Trans R Soc Lond B Biol Sci (2003) 1.03

Node of Ranvier disruption as a cause of neurological diseases. ASN Neuro (2013) 1.01

Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction. J Physiol (2009) 1.01

Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. Am J Pathol (2009) 1.00

Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium. Proc Natl Acad Sci U S A (2001) 0.98

Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proc Natl Acad Sci U S A (2009) 0.97

Effects of detergents on the redistribution of gangliosides and GPI-anchored proteins in brain tissue sections. J Histochem Cytochem (2007) 0.94

Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis. Brain (2013) 0.93

A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. Hum Mol Genet (2013) 0.93

Glycolipid and ganglioside metabolism imbalances in Huntington's disease. Neurobiol Dis (2007) 0.93

The lysosomal sialic acid transporter sialin is required for normal CNS myelination. J Neurosci (2009) 0.93

Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci U S A (2002) 0.92

GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice. J Lipid Res (2008) 0.91

Concepts for regulation of axon integrity by enwrapping glia. Front Cell Neurosci (2013) 0.91

Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia (2010) 0.90

Fluorescently-tagged anti-ganglioside antibody selectively identifies peripheral nerve in living animals. Sci Rep (2015) 0.89

Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J (2004) 0.89

The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. J Neurosci (2013) 0.89

Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth. J Neurosci (2011) 0.89

Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons. J Biol Chem (2011) 0.89

Ganglioside biochemistry. ISRN Biochem (2012) 0.89

Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res (2011) 0.88

Synthesis, Processing, and Function of N-glycans in N-glycoproteins. Adv Neurobiol (2014) 0.87

Fcγ receptor-mediated inflammation inhibits axon regeneration. PLoS One (2014) 0.87

Oligodendrocyte development and myelin biogenesis: parsing out the roles of glycosphingolipids. Physiology (Bethesda) (2009) 0.86

Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid. Br J Cancer (2004) 0.86

Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism. ACS Chem Neurosci (2010) 0.86

Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. Proc Natl Acad Sci U S A (2013) 0.86

Passive transfer of IgG anti-GM1 antibodies impairs peripheral nerve repair. J Neurosci (2010) 0.85

The pre-synaptic motor nerve terminal as a site for antibody-mediated neurotoxicity in autoimmune neuropathies and synaptopathies. J Anat (2013) 0.84

Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis. Glycoconj J (2010) 0.84

The role of gangliosides in neurodevelopment. Nutrients (2015) 0.83

Erythropoietin enhances nerve repair in anti-ganglioside antibody-mediated models of immune neuropathy. PLoS One (2011) 0.83

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. Dis Model Mech (2015) 0.82

Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. J Neurosci (2014) 0.82

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2015) 0.81

Sphingolipids and membrane biology as determined from genetic models. Prostaglandins Other Lipid Mediat (2007) 0.81

Differential distribution of major brain gangliosides in the adult mouse central nervous system. PLoS One (2013) 0.81

Human genetic disorders of sphingolipid biosynthesis. J Inherit Metab Dis (2014) 0.81

Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain? Top Curr Chem (2015) 0.81

Gangliosides of the Vertebrate Nervous System. J Mol Biol (2016) 0.80

Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function. Glycoconj J (2014) 0.80

The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease. Biomed Res Int (2014) 0.79

Distinct contributions of Galgt1 and Galgt2 to carbohydrate expression and function at the mouse neuromuscular junction. Mol Cell Neurosci (2012) 0.79

Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization. Glycoconj J (2004) 0.78

Sialylation regulates brain structure and function. FASEB J (2015) 0.78

A role for Galgt1 in skeletal muscle regeneration. Skelet Muscle (2015) 0.78

GD1b-derived gangliosides modulate FcεRI endocytosis in mast cells. J Histochem Cytochem (2011) 0.77

hnRNP A1 and secondary structure coordinate alternative splicing of Mag. RNA (2013) 0.76

Human-derived natural antibodies: biomarkers and potential therapeutics. Future Neurol (2015) 0.76

The consequences of genetic and pharmacologic reduction in sphingolipid synthesis. J Inherit Metab Dis (2014) 0.76

Apprehending ganglioside diversity: a comprehensive methodological approach. J Lipid Res (2015) 0.76

Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency. Proc Natl Acad Sci U S A (2016) 0.75

Sialic Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG. Front Mol Neurosci (2016) 0.75

A monoclonal natural human IgM protects axons in the absence of remyelination. J Neuroinflammation (2016) 0.75

Physiological Exploration of the Long-term Evolutionary Selection Against Expression of N-glycolylneuraminic Acid in the Brain. J Biol Chem (2017) 0.75

Impaired Levels of Gangliosides in the Corpus Callosum of Huntington Disease Animal Models. Front Neurosci (2016) 0.75

Glycosphingolipid-Protein Interaction in Signal Transduction. Int J Mol Sci (2016) 0.75

Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord. J Neuroinflammation (2014) 0.75

Axonal degeneration in dorsal columns of spinal cord does not induce recruitment of hematogenous macrophages. Exp Neurol (2013) 0.75

GD3- and O-acetylated GD3-gangliosides in the GM2 synthase-deficient mouse brain and their immunohistochemical localization. Proc Jpn Acad Ser B Phys Biol Sci (2006) 0.75

Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination. Brain (2017) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Altering the genome by homologous recombination. Science (1989) 12.73

A theory of the effects of fibre size in medullated nerve. J Physiol (1951) 10.15

Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell (1996) 7.70

Myelination in rat brain: method of myelin isolation. J Neurochem (1973) 4.01

Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci (1998) 2.43

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Proc Natl Acad Sci U S A (1996) 2.10

A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder. J Clin Invest (1999) 1.96

Relative conduction velocities of small myelinated and non-myelinated fibres in the central nervous system. Nat New Biol (1972) 1.80

A new procedure for the extraction, purification and fractionation of brain gangliosides. Biochim Biophys Acta (1973) 1.79

Myelinated nerve fibres in the CNS. Prog Neurobiol (1993) 1.79

Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron (1994) 1.71

Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin. Proc Natl Acad Sci U S A (1977) 1.61

Ganglioside metabolism. Enzymology, Topology, and regulation. J Biol Chem (1993) 1.59

The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J Cell Biol (1989) 1.52

Sampling schemes for estimating nerve fibre size. I. Methods for nerve trunks of mixed fascicularity. J Anat (1984) 1.50

Gangliosides are neuronal ligands for myelin-associated glycoprotein. Proc Natl Acad Sci U S A (1996) 1.46

Subunit composition of neurofilaments specifies axonal diameter. J Cell Biol (1996) 1.39

Specificity of mouse and human monoclonal antibodies to myelin-associated glycoprotein. Neurology (1984) 1.30

Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J Neurosci (1996) 1.28

Myelin-associated glycoprotein. Location and potential functions. Ann N Y Acad Sci (1990) 1.26

On the relation between fibre diameter and conduction velocity in myelinated nerve fibres. Proc R Soc Lond B Biol Sci (1982) 1.23

Designation and schematic structure of gangliosides and allied glycosphingolipids. Prog Brain Res (1994) 1.21

Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci (1995) 1.20

Sampling schemes for estimating nerve fibre size. II. Methods for unifascicular nerve trunks. J Anat (1984) 1.10

Sialic acid specificity of myelin-associated glycoprotein binding. J Biol Chem (1997) 1.09

Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). Brain Res (1997) 1.05

The distribution of ganglioside-like moieties in peripheral nerves. Brain (1999) 1.05

An efficient sampling scheme for estimating fibre number from nerve cross sections: the fractionator. J Anat (1988) 1.05

Galactosphingolipids and axono-glial interaction in myelin of the central nervous system. Cell Tissue Res (1998) 1.02

The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J Neurosci (1998) 1.01

Epidermal denervation and its effects on keratinocytes and Langerhans cells. J Neurocytol (1996) 0.98

Glycosphingolipids in cell surface recognition. Glycobiology (1991) 0.94

beta-1,4-N-Acetylgalactosaminyltransferase involved in ganglioside synthesis: cDNA sequence, expression, and chromosome mapping of the mouse gene. Genomics (1995) 0.91

Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein. Glia (1995) 0.87

Myelin associated glycoprotein modulates glia-axon contact in vivo. J Neurosci Res (1998) 0.86

Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein. J Neurocytol (1996) 0.84

Possible involvement of polysialogangliosides in nerve sprouting and cell contact formation: an ultracytochemical in vitro study. J Neurochem (1989) 0.82

High-resolution mapping of GenS3 and B11F7 epitopes on myelin-associated glycoprotein by expression PCR. J Neurochem (1994) 0.79

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61

Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology (2007) 8.08

Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest (2000) 5.48

Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28

HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96

The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88

The survival motor neuron protein in spinal muscular atrophy. Hum Mol Genet (1997) 4.86

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58

Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53

The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39

Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood (1989) 4.17

Transmission of electrical signals by spin-wave interconversion in a magnetic insulator. Nature (2010) 4.10

Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00

Smoking cessation with and without assistance: a population-based analysis. Am J Prev Med (2000) 3.92

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84

Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75

Antibody-mediated clearance of alphavirus infection from neurons. Science (1991) 3.70

Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65

Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63

The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology (2003) 3.60

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59

Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40

Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol (1998) 3.39

Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem (2000) 3.34

Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32

Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26

Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem (2001) 3.24

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22

Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron (1989) 3.06

Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06

Spin Seebeck insulator. Nat Mater (2010) 3.01

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99

Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. EMBO J (1993) 2.92

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91

Nanostructured high-strength molybdenum alloys with unprecedented tensile ductility. Nat Mater (2013) 2.90

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90

Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82

Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81

Studies on the biochemical basis of spontaneous mutation. II. The incorporation of a base and its analogue into DNA by wild-type, mutator and antimutator DNA polymerases. J Mol Biol (1974) 2.79

Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71

Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet (1995) 2.64

The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62

Guillain-Barré syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies. Brain (1995) 2.61

Molecular characterization and transcriptional analysis of type 8 capsule genes in Staphylococcus aureus. J Bacteriol (1997) 2.58

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53

Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53

Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol (1992) 2.52

Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50

Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48

On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47

Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47

Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47

Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46

Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci (1998) 2.43

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther (2004) 2.42

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41

The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell (2000) 2.41

Membrane receptors for bacterial toxins. Microbiol Rev (1983) 2.41

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell (1993) 2.40

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36

Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36

Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34

Multifocal motor neuropathy: response to human immune globulin. Ann Neurol (1993) 2.32

Patterns of Guillain-Barre syndrome in children: results from a Mexican population. Neurology (2007) 2.32

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32

The transcriptome of the arbuscular mycorrhizal fungus Glomus intraradices (DAOM 197198) reveals functional tradeoffs in an obligate symbiont. New Phytol (2011) 2.29

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26

Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity (1996) 2.24

Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol (1993) 2.23

Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol (2001) 2.23

Odd-parity superconductivity in Sr2RuO4. Science (2004) 2.22

Systemic gene expression after intravenous DNA delivery into adult mice. Science (1993) 2.21

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21

Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EMBO J (2001) 2.19

Adrenomyeloneuropathy: a probable variant of adrenoleukodystrophy. I. Clinical and endocrinologic aspects. Neurology (1977) 2.19

Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity (1999) 2.18

A novel cDNA detects homozygous microdeletions in greater than 50% of type I spinal muscular atrophy patients. Nat Genet (1995) 2.17

Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke (2001) 2.16