Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation.

PubWeight™: 2.19‹?› | Rank: Top 2%

🔗 View Article (PMID 10379865)

Published in Genes Chromosomes Cancer on July 01, 1999

Authors

T Ried1, K Heselmeyer-Haddad, H Blegen, E Schröck, G Auer

Author Affiliations

1: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

Articles citing this

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer (2000) 2.73

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS One (2010) 2.21

Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene (2007) 2.14

Retracted Novel management of oral cancer: a paradigm of predictive oncology. Clin Med Res (2004) 2.14

Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res (2007) 2.12

Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer. Thyroid (2010) 2.05

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80

Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res (2004) 1.74

The universal dynamics of tumor growth. Biophys J (2003) 1.73

Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res (2007) 1.53

Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am J Pathol (1999) 1.36

Mechanisms of metastasis. Breast Cancer Res (2008) 1.34

Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia. Am J Pathol (2003) 1.33

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Res (2004) 1.32

Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer. Am J Pathol (2005) 1.32

Aneuploidy-dependent massive deregulation of the cellular transcriptome and apparent divergence of the Wnt/beta-catenin signaling pathway in human rectal carcinomas. Cancer Res (2006) 1.31

Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc Natl Acad Sci U S A (2002) 1.30

Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma. BMC Cancer (2005) 1.27

A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. PLoS One (2008) 1.14

Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma. Cancer Res (2012) 1.05

Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. Br J Cancer (2007) 1.04

Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines. PLoS One (2012) 1.03

Aneuploidy and malignancy: an unsolved equation. J Clin Pathol (2004) 1.00

Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer. Front Oncol (2014) 1.00

Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues. BMC Cancer (2010) 0.99

The consequences of chromosomal aneuploidy on the transcriptome of cancer cells. Biochim Biophys Acta (2012) 0.97

Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. Cancer Res (2013) 0.95

Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance. Neoplasia (2008) 0.94

Karyotypic "state" as a potential determinant for anticancer drug discovery. Proc Natl Acad Sci U S A (2005) 0.93

Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances. Genes Chromosomes Cancer (2011) 0.92

Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers. Int J Colorectal Dis (2006) 0.92

Centrosome and retroviruses: the dangerous liaisons. Retrovirology (2007) 0.90

Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer. Int J Clin Exp Pathol (2013) 0.88

Multi-layered cancer chromosomal instability phenotype. Front Oncol (2013) 0.88

A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types. Int J Biol Markers (2010) 0.86

Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy. Cancer Genet Cytogenet (2009) 0.86

Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea. Proc Natl Acad Sci U S A (2002) 0.86

Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7. Cancer Genet Cytogenet (2006) 0.85

Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics. Am J Pathol (2001) 0.85

Cytogenetic profile of unknown primary tumors: clues for their pathogenesis and clinical management. Neoplasia (2003) 0.85

A new whole genome amplification method for studying clonal evolution patterns in malignant colorectal polyps. Genes Chromosomes Cancer (2012) 0.85

Molecular cytogenetics of mouse models of breast cancer. Breast Dis (2004) 0.85

Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization. PLoS One (2013) 0.85

Targeting karyotypic complexity and chromosomal instability of cancer cells. Curr Drug Targets (2010) 0.84

Genetic aberrations of c-myc and CCND1 in the development of invasive bladder cancer. Br J Cancer (2002) 0.84

Anatomic site based ploidy analysis of oral premalignant lesions. Head Neck Pathol (2009) 0.83

Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer. Crit Rev Oncol Hematol (2009) 0.83

Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes. Mol Cancer (2011) 0.83

Finding exclusively deleted or amplified genomic areas in lung adenocarcinomas using a novel chromosomal pattern analysis. BMC Med Genomics (2009) 0.82

Genetic imbalances in precursor lesions of endometrial cancer detected by comparative genomic hybridization. Am J Pathol (2000) 0.81

Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis. BMC Cancer (2015) 0.80

Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells. Environ Mol Mutagen (2009) 0.80

Highly comprehensive karyotype analysis by a combination of spectral karyotyping (SKY), microdissection, and reverse painting (SKY-MD). Chromosome Res (2001) 0.79

Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization. PLoS One (2011) 0.79

Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells. Carcinogenesis (2013) 0.79

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma. J Transl Med (2013) 0.78

Advanced molecular cytogenetics in human and mouse. Expert Rev Mol Diagn (2004) 0.78

Mouse models of colorectal cancer. Chin J Cancer (2011) 0.78

Genomic profiling of submucosal-invasive gastric cancer by array-based comparative genomic hybridization. PLoS One (2011) 0.77

The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Dig Dis Sci (2014) 0.76

Impact of gene dosage on gene expression, biological processes and survival in cervical cancer: a genome-wide follow-up study. PLoS One (2014) 0.76

A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis. Math Biosci (2005) 0.75

Articles by these authors

Role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harb Symp Quant Biol (1993) 3.38

Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer (1996) 3.30

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet (1997) 3.11

Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping. Cancer Res (1999) 3.06

Multicolour spectral karyotyping of mouse chromosomes. Nat Genet (1996) 2.90

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci U S A (1996) 2.81

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer (2000) 2.73

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet (1993) 2.64

Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood (1998) 2.36

Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization. Cancer Res (1994) 2.31

Stereotactic fine-needle biopsy in 2594 mammographically detected non-palpable lesions. Lancet (1989) 2.22

Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q. Genes Chromosomes Cancer (1997) 2.06

Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res (1995) 2.04

Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumors by comparative genomic hybridization after universal DNA-amplification. Hum Mol Genet (1993) 1.91

Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X chromosome territories have similar volumes but differ in shape and surface structure. J Cell Biol (1996) 1.82

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. Science (1996) 1.82

Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. Gut (2008) 1.77

Quantitative analysis of comparative genomic hybridization. Cytometry (1995) 1.72

Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. FEBS Lett (1999) 1.68

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol (1994) 1.62

Prevention of tumour cell dissemination in diagnostic needle procedures. Br J Cancer (2010) 1.57

Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. Nat Genet (1997) 1.57

Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms. Genes Chromosomes Cancer (2001) 1.38

Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). Nat Genet (1994) 1.36

Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am J Pathol (1999) 1.36

PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas. Br J Cancer (2007) 1.34

A recurring pattern of chromosomal aberrations in mammary gland tumors of MMTV-cmyc transgenic mice. Genes Chromosomes Cancer (1999) 1.26

Laminin-5 as a marker of invasiveness in cervical lesions. J Natl Cancer Inst (1999) 1.25

Prognostic significance of nuclear DNA content in mammary adenocarcinomas in humans. Cancer Res (1984) 1.23

Epithelial-myoepithelial duct carcinoma of salivary glands: a follow-up and cytophotometric study of 21 cases. J Oral Pathol Med (1989) 1.23

Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy. Cancer Res (1996) 1.23

Prognostic factors for adenoid cystic carcinoma of the head and neck: a retrospective evaluation of 96 cases. J Oral Pathol Med (1990) 1.20

The interactions of the flavivirus envelope proteins: implications for virus entry and release. Arch Virol Suppl (1994) 1.20

Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg (1992) 1.19

Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth. J Biol Chem (1996) 1.18

Primary small-cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations. Int J Cancer (1997) 1.16

Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors. Int J Cancer (1997) 1.15

Proliferative activity and cytochemical properties of nuclear chromatin related to local cell density of epithelial cells. Exp Cell Res (1970) 1.13

Identification of de novo chromosomal markers and derivatives by spectral karyotyping. Hum Genet (1998) 1.11

Cancer proteomics: from identification of novel markers to creation of artifical learning models for tumor classification. Electrophoresis (2000) 1.11

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients. Br J Cancer (2008) 1.09

Assessment of malignancy potential in so-called interval mammary carcinomas. Breast Cancer Res Treat (1985) 1.08

Tumor cytogenetics revisited: comparative genomic hybridization and spectral karyotyping. J Mol Med (Berl) (1998) 1.07

Spectral karyotyping, a 24-colour FISH technique for the identification of chromosomal rearrangements. Histochem Cell Biol (1998) 1.06

Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts. Carcinogenesis (1996) 1.05

Expression of tropomyosin isoforms in benign and malignant human breast lesions. Br J Cancer (1996) 1.05

Sequential proteome alterations during genesis and progression of colon cancer. Cell Mol Life Sci (2004) 1.04

Comparative genomic hybridization analysis of human parathyroid tumors. Cancer Genet Cytogenet (1998) 1.04

Quantitative cytochemical aspects of a combined feulgen-naphthol yellow S staining procedure for the simultaneous determination of nuclear and cytoplasmic proteins and DNA in mammalian cells. Exp Cell Res (1975) 1.02

ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation. Clin Exp Metastasis (1999) 1.01

Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping. Cancer Res (1997) 1.00

Correlation between stromelysin-3 mRNA level and outcome of human breast cancer. Int J Cancer (1994) 1.00

Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics (1996) 0.99

Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL. Genes Chromosomes Cancer (1998) 0.99

Chromosome painting: a useful art. Hum Mol Genet (1998) 0.98

Analysis of polypeptide expression in benign and malignant human breast lesions. Electrophoresis (1997) 0.98

Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2. Br J Haematol (2001) 0.97

Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease. World J Surg (1999) 0.97

Identification of two distinct deleted regions on chromosome 13 in prostate cancer. Oncogene (1998) 0.96

Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins. Br J Cancer (1996) 0.96

Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas. Br J Cancer (2006) 0.95

Characterization of gene expression in clinical lung cancer materials by two-dimensional polyacrylamide gel electrophoresis. Electrophoresis (1994) 0.95

Genesis of squamous cell lung carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expression. Am J Pathol (1994) 0.94

In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. Br J Cancer (2010) 0.94

Characterisation of breast fine-needle aspiration biopsies by centrosome aberrations and genomic instability. Br J Cancer (2005) 0.93

Application of confocal laser microscopy and three-dimensional Voronoi diagrams for volume and surface estimates of interphase chromosomes. J Microsc (1995) 0.93

Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability. J Med Genet (2005) 0.93

Prenatal diagnosis of a mosaic extra structurally abnormal chromosome by spectral karyotyping. Prenat Diagn (1999) 0.93

Reversibility of bronchial cell atypia. Cancer Res (1982) 0.93

Proteomic identification of p53-dependent protein phosphorylation. Oncogene (2008) 0.92

Classification of human ovarian tumors using multivariate data analysis of polypeptide expression patterns. Int J Cancer (2000) 0.91

Distinct deleted regions on chromosome segment 16q23-24 associated with metastases in prostate cancer. Genes Chromosomes Cancer (1999) 0.91

Laminin-5 gamma 2 chain expression correlates with unfavorable prognosis in colon carcinomas. Anal Cell Pathol (2001) 0.91

Identification of gel-separated tumor marker proteins by mass spectrometry. Electrophoresis (2000) 0.91

Analysis of B-cell neoplasias by spectral karyotyping (SKY). Curr Top Microbiol Immunol (1999) 0.91

Relationship between TA01 and TA02 polypeptides associated with lung adenocarcinoma and histocytological features. Br J Cancer (1997) 0.91

MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion. Br J Cancer (2013) 0.91

Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions. Mod Pathol (2001) 0.91

Detection of polypeptides associated with the histopathological differentiation of primary lung carcinoma. Br J Cancer (1995) 0.90

Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. Br J Cancer (2010) 0.90

Histopathologic characteristics and nuclear DNA content as prognostic factors in medullary thyroid carcinoma. A nationwide study in Sweden. The Swedish MTC Study Group. Cancer (1989) 0.90

Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping. Genes Chromosomes Cancer (1999) 0.89

Undifferentiated pelvic adenocarcinomas: diagnostic potential of protein profiling and multivariate analysis. Int J Colorectal Dis (2008) 0.88

Analysis of ovarian borderline tumors using comparative genomic hybridization and fluorescence in situ hybridization. Genes Chromosomes Cancer (1999) 0.88

Tumour budding detected by laminin-5 {gamma}2-chain immunohistochemistry is of prognostic value in epidermoid anal cancer. Ann Oncol (2005) 0.87

Genomic instability and proliferative activity as risk factors for distant metastases in breast cancer. Br J Cancer (2008) 0.87

Different risk groups in node-negative breast cancer: prognostic value of cytophotometrically assessed DNA, morphometry and texture. Int J Cancer (1995) 0.87

Protein expression patterns in primary carcinoma of the vagina. Br J Cancer (2004) 0.87

Requirement for mevalonate in the control of proliferation of human breast cancer cells. Anticancer Res (1992) 0.87