Stability, precision, and near-24-hour period of the human circadian pacemaker.

PubWeight™: 7.74‹?› | Rank: Top 0.1%

🔗 View Article (PMID 10381883)

Published in Science on June 25, 1999

Authors

C A Czeisler1, J F Duffy, T L Shanahan, E N Brown, J F Mitchell, D W Rimmer, J M Ronda, E J Silva, J S Allan, J S Emens, D J Dijk, R E Kronauer

Author Affiliations

1: Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.

Associated clinical trials:

Effects of Chronic Sleep Restriction in Young and Older People | NCT00506428

Articles citing this

(truncated to the top 100)

The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65

Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A (2009) 6.67

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol (2000) 4.39

Implementing a 48 h EWTD-compliant rota for junior doctors in the UK does not compromise patients' safety: assessor-blind pilot comparison. QJM (2009) 4.23

History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles (2013) 4.05

A phase response curve to single bright light pulses in human subjects. J Physiol (2003) 3.29

Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med (2012) 3.08

A detailed predictive model of the mammalian circadian clock. Proc Natl Acad Sci U S A (2003) 3.07

Sleep complaints in community-living older persons: a multifactorial geriatric syndrome. J Am Geriatr Soc (2007) 2.66

Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell (2007) 2.63

Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review. Sleep (2007) 2.43

Effects of aging on central and peripheral mammalian clocks. Proc Natl Acad Sci U S A (2002) 2.38

The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol (2005) 2.13

Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proc Natl Acad Sci U S A (2011) 1.97

Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases. Am J Pathol (2001) 1.94

Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A (2010) 1.83

Temporal disorganization of circadian rhythmicity and sleep-wake regulation in mechanically ventilated patients receiving continuous intravenous sedation. Sleep (2012) 1.82

A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol (2012) 1.79

Entrainment of the human circadian pacemaker to longer-than-24-h days. Proc Natl Acad Sci U S A (2007) 1.70

Uncovering residual effects of chronic sleep loss on human performance. Sci Transl Med (2010) 1.66

Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans. Proc Natl Acad Sci U S A (2001) 1.66

Non-random fluctuations and multi-scale dynamics regulation of human activity. Physica A (2004) 1.63

Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics. Proc Natl Acad Sci U S A (2007) 1.61

Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans. J Biol Rhythms (2005) 1.56

Is there an intrinsic period of the circadian clock? Science (2000) 1.55

Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Sci (2006) 1.52

How to trick mother nature into letting you fly around or stay up all night. J Biol Rhythms (2005) 1.50

Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans. Am J Physiol Endocrinol Metab (2004) 1.50

Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms. Clin Psychol Rev (2010) 1.48

The Gordon Wilson Lecture: work hours, sleep and patient safety in residency training. Trans Am Clin Climatol Assoc (2006) 1.44

Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J Clin Endocrinol Metab (2010) 1.43

Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. Sleep Med Clin (2009) 1.42

Circadian system, sleep and endocrinology. Mol Cell Endocrinol (2011) 1.38

Age-related decline in circadian output. J Neurosci (2011) 1.38

Preflight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light. J Biol Rhythms (2003) 1.38

Urinary 6-sulfatoxymelatonin levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst (2008) 1.37

Cycling behavior and memory formation. J Neurosci (2009) 1.37

Human blood metabolite timetable indicates internal body time. Proc Natl Acad Sci U S A (2012) 1.37

An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. J Biol Rhythms (2008) 1.36

Breast cancer and circadian disruption from electric lighting in the modern world. CA Cancer J Clin (2013) 1.31

Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc Natl Acad Sci U S A (2014) 1.30

Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior. Proc Natl Acad Sci U S A (2004) 1.30

How jet lag impairs Major League Baseball performance. Proc Natl Acad Sci U S A (2017) 1.24

Human phase response curve to a 1 h pulse of bright white light. J Physiol (2012) 1.23

Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis. Proc Natl Acad Sci U S A (2008) 1.22

Plasticity of the intrinsic period of the human circadian timing system. PLoS One (2007) 1.21

Urinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohort. Cancer Epidemiol Biomarkers Prev (2010) 1.20

Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J Clin Endocrinol Metab (2005) 1.20

Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing. Proc Natl Acad Sci U S A (2013) 1.19

Racial differences in the human endogenous circadian period. PLoS One (2009) 1.16

Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects. Neurobiol Aging (2006) 1.15

The impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res (2012) 1.11

Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res (2011) 1.10

Circadian rhythms, sleep deprivation, and human performance. Prog Mol Biol Transl Sci (2013) 1.10

Circadian misalignment and health. Int Rev Psychiatry (2014) 1.08

Scheduled bright light for treatment of insomnia in older adults. J Am Geriatr Soc (2009) 1.07

Visual impairment and circadian rhythm disorders. Dialogues Clin Neurosci (2007) 1.07

The impact of a week of simulated night work on sleep, circadian phase, and performance. Occup Environ Med (2003) 1.06

The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One (2010) 1.05

Sleep, wake and phase dependent changes in neurobehavioral function under forced desynchrony. Sleep (2011) 1.04

Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med (2015) 1.03

Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. Sleep (2013) 1.03

Lack of short-wavelength light during the school day delays dim light melatonin onset (DLMO) in middle school students. Neuro Endocrinol Lett (2010) 1.03

Circadian and wake-dependent influences on subjective sleepiness, cognitive throughput, and reaction time performance in older and young adults. Sleep (2010) 1.03

A mathematical model of the sleep/wake cycle. J Math Biol (2009) 1.02

Effect of Light on Human Circadian Physiology. Sleep Med Clin (2009) 1.02

The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PLoS One (2011) 1.02

The Per2 negative feedback loop sets the period in the mammalian circadian clock mechanism. PLoS Comput Biol (2007) 1.02

Blacks (African Americans) have shorter free-running circadian periods than whites (Caucasian Americans). Chronobiol Int (2012) 1.02

How To Travel the World Without Jet lag. Sleep Med Clin (2009) 1.01

Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One (2012) 1.00

Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. Sleep (2007) 1.00

Light and chronobiology: implications for health and disease. Dialogues Clin Neurosci (2012) 0.99

An endogenous circadian rhythm of respiratory control in humans. J Physiol (2000) 0.98

Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin. FASEB J (2012) 0.97

Neuroimaging, cognition, light and circadian rhythms. Front Syst Neurosci (2014) 0.97

Maternal feeding controls fetal biological clock. PLoS One (2008) 0.96

PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase. Am J Physiol Heart Circ Physiol (2008) 0.96

Cell cycle regulation by light in Prochlorococcus strains. Appl Environ Microbiol (2001) 0.96

Comparison of subjective and objective assessments of sleep in healthy older subjects without sleep complaints. J Sleep Res (2009) 0.96

Responsiveness of the aging circadian clock to light. Neurobiol Aging (2005) 0.96

Intrinsically photosensitive retinal ganglion cell function in relation to age: a pupillometric study in humans with special reference to the age-related optic properties of the lens. BMC Ophthalmol (2012) 0.95

Human tau in an ultradian light-dark cycle. J Biol Rhythms (2008) 0.95

Phase angle of entrainment in morning- and evening-types under naturalistic conditions. Chronobiol Int (2009) 0.95

Analysis method and experimental conditions affect computed circadian phase from melatonin data. PLoS One (2012) 0.95

Human phase response curve to a single 6.5 h pulse of short-wavelength light. J Physiol (2012) 0.95

Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker. J Theor Biol (2007) 0.93

Short nights attenuate light-induced circadian phase advances in humans. J Clin Endocrinol Metab (2005) 0.93

Combination of light and melatonin time cues for phase advancing the human circadian clock. Sleep (2013) 0.93

Relationship between nocturnal serotonin surge and melatonin onset in rodent pineal gland. J Circadian Rhythms (2006) 0.93

Night shift work and levels of 6-sulfatoxymelatonin and cortisol in men. Cancer Epidemiol Biomarkers Prev (2013) 0.92

Circadian rhythms and sleep have additive effects on respiration in the rat. J Physiol (2001) 0.91

Prolonged-release melatonin for insomnia - an open-label long-term study of efficacy, safety, and withdrawal. Ther Clin Risk Manag (2011) 0.91

Evening daylight may cause adolescents to sleep less in spring than in winter. Chronobiol Int (2010) 0.91

Altered circadian rhythmicity in patients in the ICU. Chest (2013) 0.91

Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology. J Biol Rhythms (2011) 0.91

Circadian-related sleep disorders and sleep medication use in the New Zealand blind population: an observational prevalence survey. PLoS One (2011) 0.91

Genetic basis of human circadian rhythm disorders. Exp Neurol (2012) 0.90

Human chronotypes from a theoretical perspective. PLoS One (2013) 0.90

Articles by these authors

Autonomic healing of polymer composites. Nature (2001) 8.87

Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science (1985) 8.53

The spontaneous and evoked release of acetylcholine from the cerebral cortex. J Physiol (1963) 4.45

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol (2000) 4.39

Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients. Science (1985) 3.81

Interpretation of cloud-climate feedback as produced by 14 atmospheric general circulation models. Science (1989) 3.60

Trajectory encoding in the hippocampus and entorhinal cortex. Neuron (2000) 3.48

Tree structures: deducing the principle of mechanical design. J Theor Biol (1976) 3.35

A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses. Science (1986) 3.20

Mosaic genome structure of simian immunodeficiency virus from west African green monkeys. EMBO J (1994) 3.19

External control of 20th century temperature by natural and anthropogenic forcings. Science (2000) 3.14

Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med (1995) 3.08

The effect of electrical stimulation and high potassium concentrations on the efflux of (3H) gamma-aminobutyric acid from brain slices. J Neurochem (1969) 3.05

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients. Science (1985) 3.05

Exposure to bright light and darkness to treat physiologic maladaptation to night work. N Engl J Med (1990) 3.01

The spontaneous release of acetylcholine from the denervated hemidiaphragm of the rat. J Physiol (1963) 2.75

Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science (1989) 2.66

Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. Am J Physiol (1999) 2.60

Dose-response relationships for resetting of human circadian clock by light. Nature (1996) 2.56

Serological evidence for virus related to simian T-lymphotropic retrovirus III in residents of west Africa. Lancet (1986) 2.48

Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature. Am J Physiol (1991) 2.42

Antiserum to a synthetic peptide recognizes the HTLV-III envelope glycoprotein. Science (1986) 2.33

Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease. J Virol (2001) 2.29

Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase. Behav Neurosci (2001) 2.24

Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol (1999) 2.08

Association between human serum-induced crisis forms in cultured Plasmodium falciparum and clinical immunity to malaria in Sudan. Infect Immun (1983) 2.08

Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance. J Sleep Res (1992) 2.07

Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus. J Biol Chem (2000) 2.05

Nodal quasiparticle in pseudogapped colossal magnetoresistive manganites. Nature (2005) 2.04

Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res (2000) 2.01

Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science (1986) 1.98

Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes. J Virol (1995) 1.97

Do plasma melatonin concentrations decline with age? Am J Med (1999) 1.94

New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM). Science (1986) 1.91

Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. J Investig Med (1999) 1.91

EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss. Am J Physiol (1999) 1.83

Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights. Am J Physiol Regul Integr Comp Physiol (2001) 1.76

Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: evidence for cross-species transmission in the wild. J Virol (1994) 1.70

The distribution and axonal transport of free amino acids and related compounds in the dorsal sensory neuron of the rat, as determined by the dansyl reaction. J Neurochem (1973) 1.70

Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans. Proc Natl Acad Sci U S A (2001) 1.66

Factors inducing periodic breathing in humans: a general model. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.65

Repeated partial sleep deprivation progressively changes in EEG during sleep and wakefulness. Sleep (1993) 1.64

Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch Gen Psychiatry (1997) 1.64

A model of human sleep homeostasis based on EEG slow-wave activity: quantitative comparison of data and simulations. Brain Res Bull (1993) 1.64

Sexual transmission of SIVagm in wild grivet monkeys. J Med Primatol (1994) 1.63

Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet (1992) 1.63

Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. Chronobiol Int (2000) 1.62

Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol (1998) 1.62

A highly divergent proviral DNA clone of SIV from a distinct species of African green monkey. Virology (1991) 1.61

The release of gamma-aminobutyric acid during inhibition in the cat visual cortex. J Physiol (1971) 1.59

Construction and analysis of non-Poisson stimulus-response models of neural spiking activity. J Neurosci Methods (2001) 1.58

A comparison of the firing properties of putative excitatory and inhibitory neurons from CA1 and the entorhinal cortex. J Neurophysiol (2001) 1.56

Receptor-mediated activation of immunodeficiency viruses in viral fusion. Science (1991) 1.56

Interactive mathematical models of subjective alertness and cognitive throughput in humans. J Biol Rhythms (1999) 1.53

Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans. Sleep Res Online (1999) 1.49

Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men. Brain Res (1996) 1.46

Spindle frequency activity in the sleep EEG: individual differences and topographic distribution. Electroencephalogr Clin Neurophysiol (1997) 1.45

Quantification of the benefit from integrating MEG and EEG data in minimum l2-norm estimation. Neuroimage (2008) 1.45

Microgravity reduces sleep-disordered breathing in humans. Am J Respir Crit Care Med (2001) 1.43

Dynamics of the sleep EEG after an early evening nap: experimental data and simulations. Am J Physiol (1996) 1.42

The central release of acetylcholine during consciousness and after brain lesions. J Physiol (1967) 1.41

The central release of acetylcholine during stimulation of the visual pathway. J Physiol (1966) 1.41

Low sensitivity of ELISA testing in early HIV infection. N Engl J Med (1986) 1.37

Characterization of new simian foamy viruses from African nonhuman primates. Virology (1997) 1.33

Phase-amplitude resetting of the human circadian pacemaker via bright light: a further analysis. J Biol Rhythms (1994) 1.32

Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women. J Clin Endocrinol Metab (1996) 1.32

Photic resetting of the human circadian pacemaker in the absence of conscious vision. J Biol Rhythms (2002) 1.31

Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia. Am J Physiol (1987) 1.31

A full-length and replication-competent proviral clone of SIVAGM from tantalus monkeys. Virology (1997) 1.30

Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure. Cereb Cortex (2007) 1.29

Time course of sleep inertia dissipation in human performance and alertness. J Sleep Res (1999) 1.29

Magnetic excitation spectra of Sr2IrO4 probed by resonant inelastic x-ray scattering: establishing links to cuprate superconductors. Phys Rev Lett (2012) 1.27

The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. J Clin Endocrinol Metab (1997) 1.26

Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure. J Physiol (1996) 1.25

Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertness. Sleep (1999) 1.24

Nonphotic entrainment of the human circadian pacemaker. Am J Physiol (1998) 1.23

Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans. J Physiol (1997) 1.23