Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species.

PubWeight™: 1.68‹?› | Rank: Top 3%

🔗 View Article (PMID 10385655)

Published in Hepatology on July 01, 1999

Authors

S L Michael1, N R Pumford, P R Mayeux, M R Niesman, J A Hinson

Author Affiliations

1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Articles citing this

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev (2012) 2.76

Macrophages and tissue injury: agents of defense or destruction? Annu Rev Pharmacol Toxicol (2011) 2.28

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol (2008) 1.93

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int (2011) 1.92

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82

Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem Res Toxicol (2009) 1.70

Mechanisms of drug-induced liver injury. AAPS J (2006) 1.65

Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Front Physiol (2012) 1.49

Translational biomarkers of acetaminophen-induced acute liver injury. Arch Toxicol (2015) 1.49

Mechanisms of immune-mediated liver injury. Toxicol Sci (2010) 1.48

The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol Lett (2009) 1.42

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol (2009) 1.21

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem (2010) 1.20

Kupffer cells in the liver. Compr Physiol (2013) 1.12

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. Am J Physiol Gastrointest Liver Physiol (2012) 1.10

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem Pharmacol (2009) 1.10

The role of chemokines in acute liver injury. Front Physiol (2012) 1.09

Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury. Free Radic Biol Med (2013) 1.05

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. Am J Physiol Gastrointest Liver Physiol (2008) 1.04

Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res (2011) 1.01

Retracted A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway. Br J Pharmacol (2002) 1.01

Dendritic cell depletion exacerbates acetaminophen hepatotoxicity. Hepatology (2011) 1.00

A comparison of the effect of nitroparacetamol and paracetamol on liver injury. Br J Pharmacol (2001) 0.97

Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg Nutr (2014) 0.96

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol (2016) 0.95

HCV-related proteins activate Kupffer cells isolated from human liver tissues. Dig Dis Sci (2010) 0.95

Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo. Int J Nanomedicine (2013) 0.94

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis (2015) 0.94

Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. J Surg Res (2009) 0.94

Role of monocytes and macrophages in experimental and human acute liver failure. World J Gastroenterol (2010) 0.93

Attenuation of Kupffer cell function in acute on chronic liver injury enhanced engraftment of transplanted hepatocytes. World J Surg (2007) 0.91

Retracted Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol (2004) 0.90

The potential of cytokines as safety biomarkers for drug-induced liver injury. Eur J Clin Pharmacol (2010) 0.89

Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver. Free Radic Biol Med (2008) 0.88

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis. Clin Exp Immunol (2015) 0.88

Bench-to-beside review: acute-on-chronic liver failure - linking the gut, liver and systemic circulation. Crit Care (2011) 0.87

Methanol extract of Melastoma malabathricum leaves exerted antioxidant and liver protective activity in rats. BMC Complement Altern Med (2013) 0.86

Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol (2012) 0.85

Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol (2012) 0.85

Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. J Pharmacol Exp Ther (2005) 0.84

alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. Br J Pharmacol (2007) 0.84

Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity. Dig Dis Sci (2008) 0.83

Vα14iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism. Biochem Biophys Res Commun (2012) 0.83

Hepatic mtDNA-TLR9-microRNA-223 forms a negative feedback loop to limit neutrophil over-activation and acetaminophen hepatotoxicity. Hepatology (2017) 0.81

Deficiency of interleukin-15 enhances susceptibility to acetaminophen-induced liver injury in mice. PLoS One (2012) 0.81

Inhibition of microsomal lipid peroxidation and protein oxidation by extracts from plants used in Bamun folk medicine (Cameroon) against hepatitis. Afr J Tradit Complement Altern Med (2008) 0.80

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity. Int J Mol Sci (2016) 0.79

Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice. Comp Hepatol (2004) 0.79

5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality. Biomed Res Int (2013) 0.79

The dual role of osteopontin in acetaminophen hepatotoxicity. Acta Pharmacol Sin (2012) 0.78

Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice. PLoS One (2016) 0.77

Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury. Sci Rep (2015) 0.77

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. Redox Biol (2016) 0.77

Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver. Adv Pharmacol (2015) 0.76

Role of the Inflammasome in Acetaminophen-induced Liver Injury and Acute Liver Failure. J Hepatol (2016) 0.75

Comparative Hepatoprotective Activity of Ethanolic Extracts of Cuscuta australis against Acetaminophen Intoxication in Wistar Rats. Int Sch Res Notices (2014) 0.75

Gadolinium chloride attenuates sepsis-induced pulmonary apoptosis and acute lung injury. ISRN Inflamm (2012) 0.75

Iridoid Glycosides Fraction Isolated from Veronica ciliata Fisch. Protects against Acetaminophen-Induced Liver Injury in Mice. Evid Based Complement Alternat Med (2017) 0.75

The Alzheimer pandemic: is paracetamol to blame? Inflamm Allergy Drug Targets (2014) 0.75

Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice. Oxid Med Cell Longev (2016) 0.75

Ly6C(hi) Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury. Front Immunol (2017) 0.75

Ruthenium red protects HepG2 cells overexpressing CYP2E1 against acetaminophen cytotoxicity. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.75

The Impact of Sterile Inflammation in Acute Liver Injury. J Clin Transl Res (2017) 0.75

Liver macrophages in healthy and diseased liver. Pflugers Arch (2017) 0.75

Articles by these authors

Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol Sci (2001) 2.00

Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol (1997) 1.66

Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol (1991) 1.57

Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose. Clin Pharmacol Ther (2008) 1.48

Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol (1998) 1.38

Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice. J Pharmacol Exp Ther (1989) 1.28

Thromboxane, prostaglandin and leukotriene receptors. Annu Rev Pharmacol Toxicol (1989) 1.27

The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study. Arch Biochem Biophys (1988) 1.17

Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide (2001) 1.16

A sensitive immunochemical assay for acetaminophen-protein adducts. J Pharmacol Exp Ther (1987) 1.13

CD4(+) T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice. Toxicol Sci (2000) 1.13

Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice. Biochem Pharmacol (1983) 1.12

Trichloroethylene accelerates an autoimmune response by Th1 T cell activation in MRL +/+ mice. Immunopharmacology (2000) 1.12

Acetaminophen-induced hepatotoxicity. Life Sci (1981) 1.09

Immunochemical detection of oxidized proteins. Chem Res Toxicol (1993) 1.09

Stereoselective formation of bromobenzene glutathione conjugates. Chem Biol Interact (1982) 1.08

Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine. J Pharmacol Exp Ther (2000) 1.04

Covalent binding of xenobiotics to specific proteins in the liver. Drug Metab Rev (1997) 1.03

Generation of reactive metabolites of N-hydroxy-phenacetin by glucoronidation and sulfation. Biochem Pharmacol (1977) 1.02

Oxidative stress and reactive nitrogen species generation during renal ischemia. Toxicol Sci (2001) 1.00

Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther (1989) 0.99

Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. . J Clin Pharmacol (2001) 0.98

Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice. Toxicol Appl Pharmacol (1990) 0.98

Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen. Biochem Pharmacol (1990) 0.98

Mechanism of paracetamol toxicity. Lancet (1990) 0.97

Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice. Toxicol Sci (2000) 0.97

N-Hydroxyacetaminophen: a microsomal metabolite of N-hydroxyphenacetin but apparently not of acetaminophen. Life Sci (1979) 0.96

Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem Pharmacol (2000) 0.96

Oxidant stress in rat liver after lipopolysaccharide administration: effect of inducible nitric-oxide synthase inhibition. J Pharmacol Exp Ther (2000) 0.96

The formation of arylating and alkylating metabolites of phenacetin in hamsters and hamster liver microsomes. Mol Pharmacol (1981) 0.94

Evaluation of Salmonella-vectored Campylobacter peptide epitopes for reduction of Campylobacter jejuni in broiler chickens. Clin Vaccine Immunol (2010) 0.94

Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts. Drug Metab Rev (1995) 0.94

Immunochemical detection of quinol--thioether-derived protein adducts. Chem Res Toxicol (1998) 0.94

Covalent binding of acetaminophen to N-10-formyltetrahydrofolate dehydrogenase in mice. J Pharmacol Exp Ther (1997) 0.93

Deferoxamine delays the development of the hepatotoxicity of acetaminophen in mice. Toxicol Lett (1999) 0.93

Dextran magnetite as a liver contrast agent. Magn Reson Med (1991) 0.93

Role of metabolites in propanil-induced hemolytic anemia. Toxicol Appl Pharmacol (1991) 0.91

Trichloroethylene activates CD4+ T cells: potential role in an autoimmune response. Drug Metab Rev (1999) 0.91

Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network. Clin Pediatr (Phila) (2001) 0.91

Reactions of N-acetyl-p-benzoquinone imine with reduced glutathione, acetaminophen, and NADPH. Mol Pharmacol (1986) 0.90

Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice. Toxicol Sci (2000) 0.90

Contribution of 3,4-dichlorophenylhydroxylamine in propanil-induced hemolytic anemia. Adv Exp Med Biol (1991) 0.89

Hepatic necrosis caused by furosemide. Nature (1974) 0.89

Immunochemical detection of protein adducts in mice treated with trichloroethylene. Chem Res Toxicol (1996) 0.89

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen. Drug Metab Dispos (1982) 0.89

Metabolism of the arylamide herbicide propanil. I. Microsomal metabolism and in vitro methemoglobinemia. Toxicol Appl Pharmacol (1990) 0.89

Lack of a role for inducible nitric oxide synthase in an experimental model of nephrotic syndrome. Biochem Pharmacol (2000) 0.89

A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein. Biochem Biophys Res Commun (1992) 0.88

Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine. Drug Metab Dispos (1996) 0.88

A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity. Biochem Biophys Res Commun (1991) 0.88

Bromobenzene and p-bromophenol toxicity and covalent binding in vivo. Life Sci (1982) 0.87

NO/cGMP signaling modulates regulation of Na+-K+-ATPase activity by angiotensin II in rat proximal tubules. Am J Physiol Renal Physiol (2001) 0.87

The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase. J Biol Chem (1987) 0.87

Reaction of mutagenic phenacetin metabolites with glutathione and DNA. Possible implications for toxicity. Mol Pharmacol (1984) 0.87

Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin. Mol Pharmacol (1977) 0.86

Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein. Toxicol Lett (1997) 0.86

Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress. Chem Res Toxicol (1996) 0.86

Temperature-dependent permeability of large unilamellar liposomes. Chem Phys Lipids (1984) 0.86

Hapten carrier conjugates associated with halothane hepatitis. Adv Exp Med Biol (1991) 0.85

Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Chem Res Toxicol (1995) 0.85

Ciprofloxacin and dexamethasone inhibit the proliferation of human retinal pigment epithelial cells in culture. Curr Eye Res (1991) 0.84

Nitric oxide generation mediates lipid A-induced oxidant injury in renal proximal tubules. Arch Biochem Biophys (1997) 0.84

Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates. Biochem Pharmacol (1978) 0.84

Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents. Clin Pharmacol Ther (2001) 0.84

2,6-Dimethylaniline--hemoglobin adducts from lidocaine in humans. Carcinogenesis (1994) 0.83

Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450. J Biol Chem (1987) 0.83

Compromised liver mitochondrial function and complex activity in low feed efficient broilers are associated with higher oxidative stress and differential protein expression. Poult Sci (2005) 0.83

The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane, and carbon tetrachloride. Drug Metab Dispos (1981) 0.82

Feasibility of blood flow measurement by externally controlled dye delivery. Invest Ophthalmol Vis Sci (1989) 0.82

Hyperthermia and temperature-sensitive liposomes: selective delivery of drugs into the eye. Jpn J Ophthalmol (1989) 0.82

Propanil-induced methemoglobinemia and hemoglobin binding in the rat. Toxicol Appl Pharmacol (1990) 0.82

Feed efficiency and mitochondrial function. Poult Sci (2006) 0.82

Modulation of hepatic sinusoidal endothelial cell function by Kupffer cells: an example of intercellular communication in the liver. Hepatology (1994) 0.82

Elimination of macrophages by liposome-encapsulated dichloromethylene diphosphonate suppresses the endotoxin-induced priming of Kupffer cells. J Leukoc Biol (1994) 0.82

Formation of chemically reactive metabolites of phenacetin and acetaminophen. Adv Exp Med Biol (1981) 0.82

Metabolism of the arylamide herbicide propanil. II. Effects of propanil and its derivatives on hepatic microsomal drug-metabolizing enzymes in the rat. Toxicol Appl Pharmacol (1990) 0.82

Molecular cloning and functional characterization of a vasotocin receptor subtype that is expressed in the shell gland and brain of the domestic chicken. Biol Reprod (2000) 0.82

Epitope characterization of acetaminophen bound to protein and nonprotein sulfhydryl groups by an enzyme-linked immunosorbent assay. J Pharmacol Exp Ther (1989) 0.81

Reactive metabolites of phenacetin and acetaminophen: a review. Environ Health Perspect (1983) 0.81

Evaluation of selected direct-fed microbial candidates on live performance and Salmonella reduction in commercial turkey brooding houses. Poult Sci (2011) 0.81

Glutamate dehydrogenase covalently binds to a reactive metabolite of acetaminophen. Chem Res Toxicol (1996) 0.81

Covalent binding and inhibition of cytochrome P4502E1 by trichloroethylene. Xenobiotica (1997) 0.81

Modulation of water proton relaxation rates by liposomes containing paramagnetic materials. Magn Reson Med (1988) 0.81

A potential method for local drug and dye delivery in the ocular vasculature. Invest Ophthalmol Vis Sci (1988) 0.81