Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubWeight™: 17.09‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 10391210)

Published in Nat Genet on July 01, 1999


M K Halushka1, J B Fan, K Bentley, L Hsie, N Shen, A Weder, R Cooper, R Lipshutz, A Chakravarti

Author Affiliations

1: Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Ohio 44106, USA.

Associated clinical trials:

Family Blood Pressure Program - GenNet Network | NCT00005268

Articles citing this

(truncated to the top 100)

Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45

The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80

Prediction of total genetic value using genome-wide dense marker maps. Genetics (2001) 41.25

Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46

SNPs3D: candidate gene and SNP selection for association studies. BMC Bioinformatics (2006) 21.54

Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52

SNAP predicts effect of mutations on protein function. Bioinformatics (2008) 15.39

Accounting for human polymorphisms predicted to affect protein function. Genome Res (2002) 14.10

Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09

HGBASE: a database of SNPs and other variations in and around human genes. Nucleic Acids Res (2000) 11.75

Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. Am J Hum Genet (2007) 10.92

Positive and negative selection on the human genome. Genetics (2001) 7.25

The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83

Genetic variation in an individual human exome. PLoS Genet (2008) 6.68

Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.). Proc Natl Acad Sci U S A (2001) 6.35

Large-scale identification of single-feature polymorphisms in complex genomes. Genome Res (2003) 6.04

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77

Medical sequencing at the extremes of human body mass. Am J Hum Genet (2007) 5.61

High-throughput variation detection and genotyping using microarrays. Genome Res (2001) 5.24

Categorization of humans in biomedical research: genes, race and disease. Genome Biol (2002) 4.84

Exome sequencing and the genetic basis of complex traits. Nat Genet (2012) 4.11

Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93

Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet (2004) 3.91

Associating genes with gene ontology codes using a maximum entropy analysis of biomedical literature. Genome Res (2002) 3.77

Single-nucleotide polymorphisms in soybean. Genetics (2003) 3.73

Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet (2000) 3.69

High-throughput genotyping with single nucleotide polymorphisms. Genome Res (2001) 3.55

A soybean transcript map: gene distribution, haplotype and single-nucleotide polymorphism analysis. Genetics (2007) 3.54

Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci U S A (2002) 3.25

Impacts of genetic bottlenecks on soybean genome diversity. Proc Natl Acad Sci U S A (2006) 3.23

The theory of discovering rare variants via DNA sequencing. BMC Genomics (2009) 3.12

How many more breast cancer predisposition genes are there? Breast Cancer Res (1999) 3.10

When did the human population size start increasing? Genetics (2000) 2.94

The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data. Am J Hum Genet (2000) 2.91

Genetic epidemiology of single-nucleotide polymorphisms. Proc Natl Acad Sci U S A (1999) 2.81

Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Res (2000) 2.79

Single nucleotide variation analysis in 65 candidate genes for CNS disorders in a representative sample of the European population. Genome Res (2003) 2.75

Determination of single-nucleotide polymorphisms by real-time pyrophosphate DNA sequencing. Genome Res (2000) 2.69

Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22. Proc Natl Acad Sci U S A (2000) 2.67

The amino-acid mutational spectrum of human genetic disease. Genome Biol (2003) 2.55

A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Res (2001) 2.49

Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res (2003) 2.48

Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density. Genetics (2000) 2.46

Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res (2008) 2.46

The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures. Am J Hum Genet (2001) 2.29

High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification. BMC Genomics (2001) 2.25

Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am J Hum Genet (2000) 2.25

Nucleotide diversity and linkage disequilibrium in loblolly pine. Proc Natl Acad Sci U S A (2004) 2.23

Genetic factors of age-related macular degeneration. Prog Retin Eye Res (2004) 2.17

Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays. Genome Res (2000) 2.13

Determinants of CpG islands: expression in early embryo and isochore structure. Genome Res (2001) 2.07

The mosaic structure of human pericentromeric DNA: a strategy for characterizing complex regions of the human genome. Genome Res (2000) 1.97

Neutral substitutions occur at a faster rate in exons than in noncoding DNA in primate genomes. Genome Res (2003) 1.94

Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Am J Hum Genet (2001) 1.91

High throughput SNP discovery and genotyping in grapevine (Vitis vinifera L.) by combining a re-sequencing approach and SNPlex technology. BMC Genomics (2007) 1.86

Global analysis of ATM polymorphism reveals significant functional constraint. Am J Hum Genet (2001) 1.80

A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet (2001) 1.80

Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet (2001) 1.80

Evidence for positive selection and population structure at the human MAO-A gene. Proc Natl Acad Sci U S A (2002) 1.79

Population genetic inference from resequencing data. Genetics (2008) 1.77

Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Res (2000) 1.71

Identification of candidate coding region single nucleotide polymorphisms in 165 human genes using assembled expressed sequence tags. Genome Res (1999) 1.70

Haplotype and missing data inference in nuclear families. Genome Res (2004) 1.69

Inbreeding and the genetic complexity of human hypertension. Genetics (2003) 1.67

Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Hum Genet (2006) 1.66

Genetics of rheumatoid arthritis: confronting complexity. Arthritis Res (1999) 1.63

Larger genetic differences within africans than between Africans and Eurasians. Genetics (2002) 1.62

Microarray-based resequencing of multiple Bacillus anthracis isolates. Genome Biol (2004) 1.61

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A (2001) 1.61

Recent advances in the genetics of rheumatoid arthritis. Curr Opin Rheumatol (2010) 1.58

Analysis of genetically complex epilepsies. Epilepsia (2005) 1.58

A genome-wide comparison of the functional properties of rare and common genetic variants in humans. Am J Hum Genet (2011) 1.56

Flexible use of high-density oligonucleotide arrays for single-nucleotide polymorphism discovery and validation. Genome Res (2001) 1.55

PredictSNP: robust and accurate consensus classifier for prediction of disease-related mutations. PLoS Comput Biol (2014) 1.52

A population threshold for functional polymorphisms. Genome Res (2003) 1.52

Minimal introns are not "junk". Genome Res (2002) 1.49

Heterogeneous patterns of variation among multiple human x-linked Loci: the possible role of diversity-reducing selection in non-africans. Genetics (2004) 1.48

Nucleotide diversity and linkage disequilibrium in cold-hardiness- and wood quality-related candidate genes in Douglas fir. Genetics (2005) 1.41

Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium. Am J Hum Genet (2000) 1.41

The matrix coalescent and an application to human single-nucleotide polymorphisms. Genetics (2002) 1.39

Human population structure and its effects on sampling Y chromosome sequence variation. Genetics (2003) 1.38

Single nucleotide polymorphism seeking long term association with complex disease. Nucleic Acids Res (2002) 1.33

Human genetic variation recognizes functional elements in noncoding sequence. Genome Res (2009) 1.33

Detection of CX3CR1 single nucleotide polymorphism and expression on archived eyes with age-related macular degeneration. Histol Histopathol (2005) 1.32

SNP discovery in pooled samples with mismatch repair detection. Genome Res (2004) 1.28

Functional genomics of membrane transporters in human populations. Genome Res (2005) 1.27

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br J Cancer (2004) 1.27

High-density single-nucleotide polymorphism maps of the human genome. Genomics (2005) 1.27

Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis. J Neurosci (2010) 1.25

Candidate gene case-control association studies: advantages and potential pitfalls. Br J Clin Pharmacol (2001) 1.24

New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev (2012) 1.23

Evolutionary adaptations to dietary changes. Annu Rev Nutr (2010) 1.23

Functional consequences of PRODH missense mutations. Am J Hum Genet (2005) 1.21

Sequence variability of a human pseudogene. Genome Res (2001) 1.18

Single-nucleotide polymorphism genotyping on optical thin-film biosensor chips. Proc Natl Acad Sci U S A (2003) 1.16

Electrochemically directed synthesis of oligonucleotides for DNA microarray fabrication. Nucleic Acids Res (2005) 1.15

Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry (2009) 1.15

A cSNP map and database for human chromosome 21. Genome Res (2001) 1.15

CanProVar: a human cancer proteome variation database. Hum Mutat (2010) 1.15

Single nucleotide polymorphisms and linkage disequilibrium in sunflower. Genetics (2007) 1.14

Articles by these authors

Identification of the cystic fibrosis gene: genetic analysis. Science (1989) 33.61

Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24

Estimating African American admixture proportions by use of population-specific alleles. Am J Hum Genet (1998) 22.90

Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23

Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science (2001) 15.54

A gene map of the human genome. Science (1996) 14.32

Comparative analyses of multi-species sequences from targeted genomic regions. Nature (2003) 13.31

Using oligonucleotide probe arrays to access genetic diversity. Biotechniques (1995) 12.18

New goals for the U.S. Human Genome Project: 1998-2003. Science (1998) 8.30

Nonuniform recombination within the human beta-globin gene cluster. Am J Hum Genet (1984) 7.97

DNA duplication associated with Charcot-Marie-Tooth disease type 1A. Cell (1991) 7.93

A DNA polymorphism discovery resource for research on human genetic variation. Genome Res (1998) 7.44

Methods to increase response rates to postal questionnaires. Cochrane Database Syst Rev (2007) 7.13

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene (2006) 6.54

Senior house officer training: is it getting better? A questionnaire survey. BMJ (1997) 5.61

Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat Med (1996) 5.35

High-throughput variation detection and genotyping using microarrays. Genome Res (2001) 5.24

Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79

Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66

Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nat Genet (1994) 4.19

Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet (2007) 4.13

The biological concept of race and its application to public health and epidemiology. J Health Polit Policy Law (1986) 4.02

An electrophoretic karyotype for Schizosaccharomyces pombe by pulsed field gel electrophoresis. Nucleic Acids Res (1987) 3.59

An STS-based radiation hybrid map of the human genome. Genome Res (1997) 3.57

Basic fallacies in the formulation of the paternity index. Am J Hum Genet (1985) 3.18

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet (1998) 3.00

Evidence for increased recombination near the human insulin gene: implication for disease association studies. Proc Natl Acad Sci U S A (1986) 2.96

Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis. Proc Natl Acad Sci U S A (2000) 2.94

Estimating the prior probability of paternity from the results of exclusion tests. Forensic Sci Int (1984) 2.91

Similarity of DNA fingerprints due to chance and relatedness. Hum Hered (1993) 2.90

Agmatine: an endogenous clonidine-displacing substance in the brain. Science (1994) 2.83

Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Res (2000) 2.79

Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. Am J Hum Genet (1990) 2.77

Trends in hospitalization rates for heart failure in the United States, 1973-1986. Evidence for increasing population prevalence. Arch Intern Med (1990) 2.65

Precipitating factors leading to decompensation of heart failure. Traits among urban blacks. Arch Intern Med (1988) 2.65

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. J Clin Invest (1997) 2.57

Assessment of the association between habitual salt intake and high blood pressure: methodological problems. Am J Epidemiol (1979) 2.56

Patterns of polymorphism and linkage disequilibrium suggest independent origins of the human growth hormone gene cluster. Proc Natl Acad Sci U S A (1984) 2.47

A note on the biologic concept of race and its application in epidemiologic research. Am Heart J (1984) 2.43

The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42

Patterns of genetic variation in Mendelian and complex traits. Annu Rev Genomics Hum Genet (2000) 2.37

Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial. JAMA (1999) 2.36

A genetic study of Hirschsprung disease. Am J Hum Genet (1990) 2.30

It's raining SNPs, hallelujah? Nat Genet (1998) 2.30

Waiting time for breast cancer surgery in Quebec. CMAJ (2001) 2.29

Evidence for reduced recombination on the nondisjoined chromosomes 21 in Down syndrome. Science (1987) 2.27

Evidence for multiple origins of the beta E-globin gene in Southeast Asia. Proc Natl Acad Sci U S A (1982) 2.24

Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray. Genes Immun (2003) 2.23

Bovine beta-lactoglobulin at 1.8 A resolution--still an enigmatic lipocalin. Structure (1997) 2.23

Coronary arteriography and coronary bypass survey among whites and other racial groups relative to hospital-based incidence rates for coronary artery disease: findings from NHDS. Am J Public Health (1989) 2.21

Rising death rates in the Soviet Union: the impact of coronary heart disease. N Engl J Med (1981) 2.17

Divergence of the recent trends in coronary mortality for the four major race-sex groups in the United States. Am J Public Health (1988) 2.16

A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter. Nucleic Acids Res (2000) 2.16

PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. J Clin Invest (1999) 2.14

Immune deficiency syndrome in children. JAMA (1983) 2.12

Endoscopic ultrasound in the evaluation of Barrett's esophagus: a preliminary report. Am J Gastroenterol (1994) 2.11

Cigarette smoking and ill health among black Americans. N Y State J Med (1985) 2.04

Multiplex PCR of three dinucleotide repeats in the Prader-Willi/Angelman critical region (15q11-q13): molecular diagnosis and mechanism of uniparental disomy. Hum Mol Genet (1993) 2.02

Standardization of blood pressure measurement in an international comparative study. J Clin Epidemiol (1996) 1.99

Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia. Blood (2001) 1.98

Proposed preliminary core set measures for disease outcome assessment in adult and juvenile idiopathic inflammatory myopathies. Rheumatology (Oxford) (2001) 1.96

The decline in mortality from coronary heart disease, U.S.A., 1968--1975. J Chronic Dis (1978) 1.92

Recent trends in coronary risk factors in the USSR. Am J Public Health (1982) 1.84

Recombination within and between the human insulin and beta-globin gene loci. Proc Natl Acad Sci U S A (1983) 1.82

Polymorphic DNA haplotypes at the LDL receptor locus. Am J Hum Genet (1989) 1.82

Allele frequency distributions in pooled DNA samples: applications to mapping complex disease genes. Genome Res (1998) 1.81

Mean and variance of FST in a finite number of incompletely isolated populations. Theor Popul Biol (1977) 1.79

Molecular characterization of two proximal deletion breakpoint regions in both Prader-Willi and Angelman syndrome patients. Am J Hum Genet (1995) 1.78

Blood vitamin concentrations during the acute-phase response. Crit Care Med (1992) 1.77

Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nat Genet (1996) 1.77

A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus. Proc Natl Acad Sci U S A (2000) 1.76

Induction of mammary gland development in estrogen receptor-alpha knockout mice. Endocrinology (2000) 1.75

International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease. Rheumatology (Oxford) (2003) 1.71

To a future of genetic medicine. Nature (2001) 1.70

Parental origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and association with the partial hydatidiform mole. Am J Hum Genet (2000) 1.69

Reversible immortalization of human myogenic cells by site-specific excision of a retrovirally transferred oncogene. Hum Gene Ther (1999) 1.66

Landmark-driven fundus perimetry using the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci (1995) 1.65

Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. Am J Hum Genet (2000) 1.65

A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome). Nat Genet (1996) 1.65

The association between urinary sodium excretion and blood pressure in children. Circulation (1980) 1.64

Racism, society, and disease: an exploration of the social and biological mechanisms of differential mortality. Int J Health Serv (1981) 1.62

Multipoint gene mapping using seriation. I. General methods. Am J Hum Genet (1987) 1.61

In-hospital mortality rates from acute myocardial infarction by race in U.S. hospitals: findings from the National Hospital Discharge Survey. Circulation (1987) 1.60

Detection of tandem duplications and implications for linkage analysis. Am J Hum Genet (1994) 1.60

Trends in mortality from cerebrovascular diseases in the United States, 1960 to 1975. Stroke (1979) 1.58

Occurrence of Cryptosporidium oocysts in fecal samples submitted for routine microbiological examination. J Clin Microbiol (1985) 1.57

Microsatellite polymorphism linkage map of human chromosome 13q. Genomics (1993) 1.56

Elevated frequency of Tay-Sachs disease among Ashkenazic Jews unlikely by genetic drift alone. Am J Hum Genet (1978) 1.55

Flexible use of high-density oligonucleotide arrays for single-nucleotide polymorphism discovery and validation. Genome Res (2001) 1.55

Improved mortality among U.S. Blacks, 1968-1978: the role of antiracist struggle. Int J Health Serv (1981) 1.53

The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. Genome Res (1999) 1.53

Pain following craniotomy: a preliminary study comparing PCA morphine with intramuscular codeine phosphate. Anaesthesia (1996) 1.51

Help of the fire brigade in a case of a strangulated penis. Ann R Coll Surg Engl (2001) 1.51

Hypertension in populations of West African origin: is there a genetic predisposition? J Hypertens (1994) 1.50

A genetic linkage map of 17 markers on human chromosome 21. Genomics (1989) 1.50