Mouse dendritic cells express the P2X7 purinergic receptor: characterization and possible participation in antigen presentation.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 10438932)

Published in J Immunol on August 15, 1999

Authors

C Mutini1, S Falzoni, D Ferrari, P Chiozzi, A Morelli, O R Baricordi, G Collo, P Ricciardi-Castagnoli, F Di Virgilio

Author Affiliations

1: Section of General Pathology, Department of Experimental and Diagnostic Medicine, Biotechnology Center, University of Ferrara, Italy.

Articles citing this

Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J (2001) 2.34

P2X7 mediates ATP-driven invasiveness in prostate cancer cells. PLoS One (2014) 1.48

P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev (2003) 1.41

Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med (2010) 1.25

P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J Immunol (2009) 1.25

Purinergic mechanism in the immune system: A signal of danger for dendritic cells. Purinergic Signal (2005) 1.10

Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer. Oncoimmunology (2012) 1.00

Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control. Am J Respir Crit Care Med (2008) 0.98

Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. J Immunol (2012) 0.97

The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis (2012) 0.95

Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells. Br J Pharmacol (2001) 0.94

The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity. Front Immunol (2013) 0.94

Purinergic signalling and immune cells. Purinergic Signal (2014) 0.94

P2 receptors and immunity. Microbes Infect (2012) 0.93

P2 purinergic receptor modulation of cytokine production. Purinergic Signal (2007) 0.93

P2X(7) receptor and polykarion formation. Mol Biol Cell (2000) 0.92

Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.89

Expression of P2X receptors on immune cells in the rat liver during postnatal development. Histochem Cell Biol (2006) 0.84

Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice. BMC Cancer (2009) 0.84

CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice. Hepatology (2013) 0.82

Noncanonical roles of the immune system in eliciting oncogene addiction. Curr Opin Immunol (2013) 0.80

Targeting ion channels for the treatment of autoimmune neuroinflammation. Ther Adv Neurol Disord (2013) 0.78

Release of IL-1beta via IL-1beta-converting enzyme in a skin dendritic cell line exposed to 2,4-dinitrofluorobenzene. Mediators Inflamm (2005) 0.77

Purinergic Signaling and the Immune Response in Sepsis: A Review. Clin Ther (2016) 0.76

Shaping immune responses through the activation of dendritic cells' P2 receptors. Purinergic Signal (2006) 0.76

Functional variant of the P2X7 receptor gene is associated with human papillomavirus-16 positive cervical squamous cell carcinoma. Oncotarget (2016) 0.75

Predictions suggesting a participation of beta-sheet configuration in the M2 domain of the P2X(7) receptor: a novel conformation? Biophys J (2009) 0.75

P2×7 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression. Sci Rep (2015) 0.75

Conditioning neoadjuvant therapies for improved immunotherapy of cancer. Biochem Pharmacol (2017) 0.75

Articles by these authors

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 11.07

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med (1998) 6.36

Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol (2001) 6.32

Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med (1999) 5.55

Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med (1999) 4.92

Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol (1999) 4.87

Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nat Cell Biol (1999) 4.53

Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature (1995) 4.18

Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med (1997) 4.04

Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther (2006) 3.93

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J (2001) 3.85

Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood (2001) 3.84

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol (2001) 3.59

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells. J Cell Biol (2000) 3.35

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem (1985) 3.31

Apoptosis signaling by death receptors. Eur J Biochem (1998) 3.06

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. Proc Natl Acad Sci U S A (2000) 3.03

Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med (2000) 2.99

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol (1997) 2.81

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J Biol Chem (1997) 2.78

Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nat Immunol (2001) 2.77

Twenty four hour manometric recording of colonic motor activity in healthy man. Gut (1987) 2.75

Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med (1998) 2.66

Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med (1997) 2.52

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J Biol Chem (1993) 2.50

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels. Nature (1984) 2.49

An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J (1996) 2.48

Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol (1998) 2.27

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18). J Exp Med (2001) 2.12

Developmental plasticity of CNS microglia. Proc Natl Acad Sci U S A (2001) 1.95

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J Cell Biol (2001) 1.87

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84

Dendritic cells shuttle microbes across gut epithelial monolayers. Immunobiology (2001) 1.83

Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses. J Exp Med (2000) 1.83

Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle. Nature (1985) 1.78

Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells. Proc Natl Acad Sci U S A (1998) 1.74

The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J Clin Invest (1995) 1.73

Ca2+-dependent and Ca2+-independent phagocytosis in human neutrophils. Nature (1985) 1.71

Prevention of cardiac surgery-associated acute kidney injury. Int J Artif Organs (2008) 1.69

P2 purinoceptors in the immune system. Ciba Found Symp (1996) 1.68

Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study. Br J Anaesth (2006) 1.64

Monokine production by microglial cell clones. Eur J Immunol (1989) 1.64

Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. J Biol Chem (1988) 1.62

Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J Immunol (2000) 1.61

Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci U S A (1991) 1.61

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP. J Immunol (1996) 1.60

Gastric acidity and gastroesophageal reflux patterns in patients with esophagitis. Gastroenterology (1992) 1.58

Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli. J Exp Med (2000) 1.56

Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J Exp Med (2000) 1.54

P2X receptors: an emerging channel family. Eur J Neurosci (1996) 1.53

Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology (1997) 1.50

Cytolytic P2X purinoceptors. Cell Death Differ (1998) 1.50

Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor. J Biol Chem (1999) 1.48

ATP-mediated cytotoxicity in microglial cells. Neuropharmacology (1997) 1.48

Giardia lamblia infestation reveals underlying Whipple's disease in a patient with longstanding constipation. Am J Gastroenterol (1991) 1.48

Responses of mouse lymphocytes to extracellular ATP. II. Extracellular ATP causes cell type-dependent lysis and DNA fragmentation. J Immunol (1990) 1.47

Coordinated events during bacteria-induced DC maturation. Immunol Today (1999) 1.47

Hepatitis B virus antigens in peripheral blood mononuclear cells during the course of viral infection. Clin Immunol Immunopathol (1994) 1.46

Blockade of human P2X7 receptor function with a monoclonal antibody. Blood (1998) 1.45

Selective endoscopic retrograde cholangiography and preoperative bile duct stone removal in patients scheduled for laparoscopic cholecystectomy: a prospective study. Am J Gastroenterol (1996) 1.45

Chronic inflammation in the pathogenesis of benign prostatic hyperplasia. Int J Androl (2009) 1.43

Effect of omeprazole and high doses of ranitidine on gastric acidity and gastroesophageal reflux in patients with moderate-severe esophagitis. Am J Gastroenterol (1990) 1.41

Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes. Eur J Immunol (1996) 1.39

Esophageal motor disorders in patients evaluated for dysphagia and/or noncardiac chest pain. Dysphagia (1992) 1.39

Intragastric pH monitoring during antisecretory therapy in patient with gastrointestinal bleeding. Am J Gastroenterol (1989) 1.38

Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J Immunol (2001) 1.37

Inositol phosphate formation in fMet-Leu-Phe-stimulated human neutrophils does not require an increase in the cytosolic free Ca2+ concentration. Biochem J (1985) 1.37

Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide. Dig Dis Sci (1986) 1.37

Colonic mass movements in idiopathic chronic constipation. Gut (1988) 1.36

Establishment, characterization and virus expression of cell lines derived from radiation- and virus-induced lymphomas of C57BL/Ka mice. Int J Cancer (1979) 1.35

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells. Biochem Biophys Res Commun (1985) 1.32

NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci U S A (2001) 1.31