Published in Genes Dev on August 15, 1999
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell (2010) 4.99
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Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol (2011) 3.51
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev (2001) 3.43
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev (2004) 3.33
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions. Cell (2015) 3.10
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev (2002) 2.75
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest (2001) 2.49
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol (2003) 2.31
Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell (2012) 2.28
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A (2003) 2.25
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev (2003) 2.21
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev (2004) 2.16
Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis (2007) 2.01
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol (2003) 1.99
Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development (2007) 1.97
Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. Proc Natl Acad Sci U S A (2010) 1.96
Development of the endochondral skeleton. Cold Spring Harb Perspect Biol (2013) 1.89
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev (2007) 1.87
Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A (2008) 1.86
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A (2007) 1.85
Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development (2005) 1.84
Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest (2005) 1.82
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78
The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75
Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest (2004) 1.74
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Am J Hum Genet (2007) 1.72
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med (2013) 1.66
Bmp2 transcription in osteoblast progenitors is regulated by a distant 3' enhancer located 156.3 kilobases from the promoter. Mol Cell Biol (2007) 1.66
Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer (2010) 1.63
Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med (2002) 1.63
Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59
Mechanism and evolution of cytosolic Hedgehog signal transduction. Development (2010) 1.58
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J Cell Biol (2011) 1.58
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell (2007) 1.57
rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair. J Bone Miner Res (2010) 1.56
Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev (2010) 1.54
Regulation of chondrogenesis and chondrocyte differentiation by stress. J Clin Invest (2008) 1.53
Genetic disorders of the skeleton: a developmental approach. Am J Hum Genet (2003) 1.52
Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A (2006) 1.46
Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol (2004) 1.45
Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol (2007) 1.44
The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development (2009) 1.41
Isometric Scaling in Developing Long Bones Is Achieved by an Optimal Epiphyseal Growth Balance. PLoS Biol (2015) 1.39
Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development (2010) 1.37
The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol (2006) 1.36
Skeletogenesis in the swell shark Cephaloscyllium ventriosum. J Anat (2007) 1.35
Deletion and point mutations of PTHLH cause brachydactyly type E. Am J Hum Genet (2010) 1.35
Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS One (2009) 1.35
Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci U S A (2003) 1.33
Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A (2006) 1.30
Vertebrate skeletogenesis. Curr Top Dev Biol (2010) 1.30
Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation. PLoS Genet (2011) 1.30
An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. J Clin Invest (2005) 1.29
Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage. Dev Cell (2014) 1.28
Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development (2009) 1.27
Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Proc Natl Acad Sci U S A (2009) 1.27
Dysregulation of chondrogenesis in human cleidocranial dysplasia. Am J Hum Genet (2005) 1.27
Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx. J Orthop Surg Res (2010) 1.27
Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One (2010) 1.26
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc Natl Acad Sci U S A (2005) 1.26
FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol (2007) 1.26
The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network. Mol Cell Endocrinol (2011) 1.23
Indian hedgehog roles in post-natal TMJ development and organization. J Dent Res (2010) 1.22
Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev (2008) 1.22
Current insights on the regenerative potential of the periosteum: molecular, cellular, and endogenous engineering approaches. J Orthop Res (2012) 1.21
Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol (2007) 1.21
Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Dev Biol (2005) 1.20
Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification. Pediatr Nephrol (2009) 1.19
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation. Development (2015) 1.19
Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol (2007) 1.19
The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One (2011) 1.18
Clock genes influence gene expression in growth plate and endochondral ossification in mice. J Biol Chem (2012) 1.18
Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors. J Clin Invest (2014) 1.18
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
Signaling hierarchy regulating human endothelial cell development. Arterioscler Thromb Vasc Biol (2009) 1.17
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet (2011) 1.16
Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. J Bone Miner Res (2012) 1.15
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol (2009) 1.15
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res (2011) 1.15
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet (2008) 1.15
Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development (2009) 1.15
The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation. BMC Dev Biol (2008) 1.13
Of hedgehogs and hereditary bone tumors: re-examination of the pathogenesis of osteochondromas. Iowa Orthop J (2003) 1.13
Aggrecan modulation of growth plate morphogenesis. Dev Biol (2009) 1.13
Generation and characterization of Col10a1-mcherry reporter mice. Genesis (2011) 1.12
mTOR signaling contributes to chondrocyte differentiation. Dev Dyn (2008) 1.12
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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell (1997) 16.78
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science (1996) 8.14
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86
Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron (1999) 7.80
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Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science (1996) 6.33
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