MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.

PubWeight™: 5.61‹?› | Rank: Top 1%

🔗 View Article (PMID 10471499)

Published in Nat Genet on September 01, 1999

Authors

H H Ng1, Y Zhang, B Hendrich, C A Johnson, B M Turner, H Erdjument-Bromage, P Tempst, D Reinberg, A Bird

Author Affiliations

1: Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, Edinburgh EH9 3JR, UK.

Articles citing this

(truncated to the top 100)

Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50

Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev (2001) 3.41

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J (2001) 3.36

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A (2002) 3.29

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol (2006) 3.05

Methylation matters. J Med Genet (2001) 3.00

5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A (2000) 2.98

Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev (2001) 2.96

The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A (2000) 2.92

The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev (2001) 2.91

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol (2009) 2.87

Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. Proc Natl Acad Sci U S A (2003) 2.70

DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases. Proc Natl Acad Sci U S A (2006) 2.68

Sin3: a flexible regulator of global gene expression and genome stability. Curr Genet (2004) 2.60

DNA methylation dynamics in health and disease. Nat Struct Mol Biol (2013) 2.58

GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J (2005) 2.56

FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53

The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev (2001) 2.48

Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation. Proc Natl Acad Sci U S A (2006) 2.46

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res (2003) 2.41

Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J (2002) 2.40

GADD45A does not promote DNA demethylation. PLoS Genet (2008) 2.36

RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol Cell Biol (2001) 2.14

DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma (2009) 2.13

Active repression of methylated genes by the chromosomal protein MBD1. Mol Cell Biol (2000) 2.12

Blocking histone deacetylation in Arabidopsis induces pleiotropic effects on plant gene regulation and development. Proc Natl Acad Sci U S A (2001) 2.05

Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation. Mol Cell Biol (2000) 1.98

Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc Natl Acad Sci U S A (2001) 1.93

Cancer epigenetics: linking basic biology to clinical medicine. Cell Res (2011) 1.88

Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest (2004) 1.87

WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A (2003) 1.78

DNA methylation and its basic function. Neuropsychopharmacology (2012) 1.76

Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol Cell Biol (2004) 1.74

Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury. Circulation (2011) 1.74

Molecular mechanisms of gene silencing mediated by DNA methylation. Mol Cell Biol (2002) 1.73

Comparative study of methyl-CpG-binding domain proteins. BMC Genomics (2003) 1.70

Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation. Mol Cell Biol (2001) 1.70

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19. Genes Dev (2000) 1.70

Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol (2006) 1.67

Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription. Nucleic Acids Res (2001) 1.64

DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle (2009) 1.64

Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci U S A (2000) 1.64

GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells. Am J Pathol (2001) 1.60

A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements. Genome Res (2008) 1.60

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging (2008) 1.60

DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol (2001) 1.55

Regulation of airway mucin gene expression. Annu Rev Physiol (2008) 1.53

Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Mol Cell Biol (2000) 1.53

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol (2002) 1.46

Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol Cell Biol (2005) 1.45

Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis. PLoS One (2012) 1.43

Rett syndrome and MeCP2: linking epigenetics and neuronal function. Am J Hum Genet (2002) 1.42

Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks. Proc Natl Acad Sci U S A (2006) 1.40

Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin? Cell Mol Life Sci (2008) 1.39

Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39

DNA methylation of cancer genome. Birth Defects Res C Embryo Today (2009) 1.39

Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. J Biol Chem (2002) 1.35

MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery. Nucleic Acids Res (2000) 1.34

DNA methylation has a local effect on transcription and histone acetylation. Mol Cell Biol (2002) 1.34

Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics (2008) 1.31

Modulation of DNA binding protein affinity directly affects target site demethylation. Mol Cell Biol (2000) 1.31

The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes. Mol Cell Biol (2005) 1.30

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA. Nucleic Acids Res (2010) 1.26

Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein. Mol Cell Biol (2005) 1.26

Aberrant promoter methylation of the ABCG2 gene in renal carcinoma. Mol Cell Biol (2006) 1.26

Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26

Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. Mol Cell Biol (2007) 1.25

Methylation-dependent silencing at the H19 imprinting control region by MeCP2. Nucleic Acids Res (2002) 1.25

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med (2011) 1.25

Cross-talk between site-specific transcription factors and DNA methylation states. J Biol Chem (2013) 1.24

Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. Mol Cell Biol (2007) 1.24

Interactions within the mammalian DNA methyltransferase family. BMC Mol Biol (2003) 1.23

Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res (2008) 1.22

T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A (2005) 1.22

MCAF mediates MBD1-dependent transcriptional repression. Mol Cell Biol (2003) 1.22

Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Mol Cell Biol (2007) 1.22

Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mol Cell Biol (2003) 1.20

Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res (2000) 1.20

Enjoy the Silence: The Story of let-7 MicroRNA and Cancer. Curr Genomics (2007) 1.19

Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol Cell Biol (2002) 1.18

Control of the DNA methylation system component MBD2 by protein arginine methylation. Mol Cell Biol (2006) 1.18

The NuRD architecture. Cell Mol Life Sci (2013) 1.18

Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J (2009) 1.16

Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol Cell Biol (2003) 1.16

Effects of histone acetylation and DNA methylation on p21( WAF1) regulation. World J Gastroenterol (2002) 1.15

The effect of interspecific oocytes on demethylation of sperm DNA. Proc Natl Acad Sci U S A (2004) 1.14

Transposons and genome evolution in plants. Proc Natl Acad Sci U S A (2000) 1.14

Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. Mol Cell Biol (2000) 1.14

Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos. EMBO J (2001) 1.13

In vitro nuclear interactome of the HIV-1 Tat protein. Retrovirology (2009) 1.13

TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. Nucleic Acids Res (2006) 1.12

MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. Mol Cell Biol (2003) 1.12

p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. Nucleic Acids Res (2006) 1.12

CpG binding protein is crucial for early embryonic development. Mol Cell Biol (2001) 1.11

DNA methylation: a mechanism for embedding early life experiences in the genome. Child Dev (2012) 1.11

The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. Mol Cell Biol (2003) 1.11

Rett syndrome: the complex nature of a monogenic disease. J Mol Med (Berl) (2003) 1.10

Articles by these authors

Electric field effect in atomically thin carbon films. Science (2004) 45.10

SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature (1998) 18.36

Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97

IntAct--open source resource for molecular interaction data. Nucleic Acids Res (2006) 13.82

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol (2000) 11.62

Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med (2000) 11.12

Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09

Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol (2001) 10.20

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet (2001) 9.82

Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev (2001) 9.54

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24

Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med (1996) 8.94

A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71

Smoking in China: findings of the 1996 National Prevalence Survey. JAMA (1999) 8.67

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell (1992) 8.10

Mammalian sweet taste receptors. Cell (2001) 8.04

Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94

Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol (1998) 7.61

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58

High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell (1990) 7.45

The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38

The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell (1998) 7.37

The general transcription factors of RNA polymerase II. Genes Dev (1996) 7.15

Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res (1999) 6.85

Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79

Significant acidification in major Chinese croplands. Science (2010) 6.68

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell (1997) 6.45

TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33

Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet (2001) 6.23

RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17

Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13

Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J (1998) 5.96

Mediating mechanisms in a school-based drug prevention program: first-year effects of the Midwestern Prevention Project. Health Psychol (1991) 5.85

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83

An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum (1998) 5.72

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell (1985) 5.63

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A (1996) 5.61

Computerized method of visual acuity testing: adaptation of the amblyopia treatment study visual acuity testing protocol. Am J Ophthalmol (2001) 5.37

Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33

A multicommunity trial for primary prevention of adolescent drug abuse. Effects on drug use prevalence. JAMA (1989) 5.31

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19

Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med (1992) 5.05

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol (1998) 5.01

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99

FACT, a factor that facilitates transcript elongation through nucleosomes. Cell (1998) 4.91

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell (1991) 4.90

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A (2000) 4.79

A human telomeric protein. Science (1995) 4.77

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell (1993) 4.76

The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother (1968) 4.75

Binding of general transcription factor TFIIB to an acidic activating region. Nature (1991) 4.71

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Nature (1999) 4.69

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II. Nature (1992) 4.63

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature (1999) 4.63

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science (1996) 4.59

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47

Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc (2001) 4.46

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature (1998) 4.43

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (1999) 4.40