Published in Nature on August 26, 1999
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol (2005) 2.80
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci (2005) 2.76
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol (2003) 2.07
Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits. Proc Natl Acad Sci U S A (2000) 1.53
Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J (2003) 1.40
Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood (2005) 1.33
Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. Mol Cell Biol (2000) 1.32
Impaired activation of murine platelets lacking G alpha(i2). J Clin Invest (2001) 1.31
Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci U S A (2000) 1.29
The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics (2003) 1.27
Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet (2010) 1.23
Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (2001) 1.14
Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget (2014) 1.11
Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell (2002) 1.09
Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinase. Neurosignals (2002) 1.07
Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck. Clin Cancer Res (2009) 1.07
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J (2000) 1.07
CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1. Mol Cell Biol (2000) 1.06
A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away. Proc Natl Acad Sci U S A (2000) 1.03
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol (2010) 1.03
Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion. Mol Cell Biol (2002) 1.02
G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol Cell Biol (2000) 0.97
Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Mol Biol Cell (2009) 0.96
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem (2009) 0.93
Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proc Natl Acad Sci U S A (2003) 0.92
Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. Cell Adh Migr (2011) 0.92
Rap1 activation plays a regulatory role in pancreatic amylase secretion. J Biol Chem (2008) 0.90
Transcriptome analyses and differential gene expression in a non-model fish species with alternative mating tactics. BMC Genomics (2014) 0.89
Regulation of neurite outgrowth by G(i/o) signaling pathways. Front Biosci (2008) 0.89
Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization. J Biol Chem (2011) 0.89
Minireview: Targeting GPCR Activated ERK Pathways for Drug Discovery. Curr Chem Genom Transl Med (2013) 0.88
Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Cell Res (2010) 0.87
Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration. J Biol Chem (2013) 0.86
Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. Biochem Pharmacol (2007) 0.85
Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain. Mol Biol Cell (2000) 0.83
The GTPase activating Rap/RanGAP domain-like 1 gene is associated with chicken reproductive traits. PLoS One (2012) 0.83
Non-neuronal functions of the m2 muscarinic acetylcholine receptor. Genes (Basel) (2013) 0.80
A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling. Biosensors (Basel) (2012) 0.79
The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood (2016) 0.79
Signal transduction. Rhapsody in G proteins. Nature (1999) 0.78
MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. Oncotarget (2016) 0.77
GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism. Med Hypotheses (2009) 0.75
Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells. PLoS One (2015) 0.75
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol (2000) 9.85
Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet (1988) 8.76
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol (1999) 7.65
A family of cAMP-binding proteins that directly activate Rap1. Science (1998) 6.12
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell (2000) 5.92
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes (2001) 5.18
A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a. Cell (1986) 4.88
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature (2001) 4.83
Prediction of acute left main coronary artery obstruction by 12-lead electrocardiography. ST segment elevation in lead aVR with less ST segment elevation in lead V(1). J Am Coll Cardiol (2001) 4.81
Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation (1983) 4.70
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med (1996) 4.61
Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. J Natl Cancer Inst (1994) 4.59
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell (1994) 4.34
Human immunodeficiency virus-like particles produced by a vaccinia virus expression vector. Proc Natl Acad Sci U S A (1989) 4.26
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry (1997) 3.90
Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation (1992) 3.73
Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein. J Virol (1994) 3.59
The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer (1999) 3.47
A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element. Nat Genet (1996) 3.45
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos. Development (1996) 3.30
Efficient promoter cassettes for enhanced expression of foreign genes in dicotyledonous and monocotyledonous plants. Plant Cell Physiol (1996) 3.30
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest (1995) 3.19
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci U S A (1998) 3.11
Specificity of DNase I. Estimation of nucleosides present at the 5'-phosphate terminus of a limit digest of DNA by DNase I. J Biochem (1966) 2.96
Transgenic mice susceptible to poliovirus. Proc Natl Acad Sci U S A (1991) 2.87
Phospholipase C assay using p-nitrophenylphosphoryl-choline together with sorbitol and its application to studying the metal and detergent requirement of the enzyme. Anal Biochem (1976) 2.87
Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev (1998) 2.82
Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particles. Virology (1993) 2.81
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia (2003) 2.80
Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae. EMBO J (1984) 2.77
Postexposure prophylaxis of varicella in family contact by oral acyclovir. Pediatrics (1993) 2.67
Human immunodeficiency virus vpr gene encodes a virion-associated protein. AIDS Res Hum Retroviruses (1990) 2.67
Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein. J Virol (1990) 2.60
Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci U S A (1994) 2.57
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A (1998) 2.47
DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol (1996) 2.44
The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A (2000) 2.42
Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity (1994) 2.39
Antithyroid drug-induced agranulocytosis. The usefulness of routine white blood cell count monitoring. Arch Intern Med (1990) 2.39
Preoperative identification of meningiomas that are highly likely to recur. J Neurosurg (1999) 2.38
Two species of human CRK cDNA encode proteins with distinct biological activities. Mol Cell Biol (1992) 2.30
SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum Mol Genet (2001) 2.30
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature (2001) 2.28
Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. J Cell Biol (1997) 2.25
Human immunodeficiency virus type 1 has an additional coding sequence in the central region of the genome. Proc Natl Acad Sci U S A (1988) 2.20
Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells. J Virol (2001) 2.17
Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11
The long-term effects of polymethylmethacrylate contact lens wear on the corneal endothelium. Ophthalmology (1994) 2.05
Role of the gag and pol genes of human immunodeficiency virus in the morphogenesis and maturation of retrovirus-like particles expressed by recombinant vaccinia virus: an ultrastructural study. J Gen Virol (1991) 2.05
A single species of pX mRNA of human T-cell leukemia virus type I encodes trans-activator p40x and two other phosphoproteins. J Virol (1986) 2.04
Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol (1999) 2.00
Percutaneous radiofrequency ablation in osteoid osteoma. J Bone Joint Surg Br (2001) 1.97
Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res (1993) 1.95
Corneal endothelial changes in type I and type II diabetes mellitus. Am J Ophthalmol (1984) 1.94
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells. Mol Cell Biol (1994) 1.92
Role of osteopontin in bone remodeling caused by mechanical stress. J Bone Miner Res (1999) 1.92
Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem (1997) 1.91
Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun (1996) 1.89
Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br J Dermatol (2003) 1.86
Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology (2000) 1.86
Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein. Genes Dev (1998) 1.85
A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors. Jpn J Cancer Res (1990) 1.83
Early cancer of the stomach. World J Surg (1979) 1.82
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development (1998) 1.81
Heteroduplex analysis of cloned rat endogenous replication-defective (30 S) retrovirus and Harvey murine sarcoma virus. Virology (1980) 1.81
A new approach for evaluation of left ventricular diastolic function: spatial and temporal analysis of left ventricular filling flow propagation by color M-mode Doppler echocardiography. J Am Coll Cardiol (1996) 1.79
Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis. J Clin Invest (1978) 1.79
Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F) Nat Struct Biol (1997) 1.75
Enhanced Na(+) channel intermediate inactivation in Brugada syndrome. Circ Res (2000) 1.74
Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes. J Pharmacol Exp Ther (1996) 1.74
Intracellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin). Adv Enzyme Regul (1980) 1.74
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J (2001) 1.74
Isolation and purification of two antigenically active, "complimentary" polypeptide fragments of tetanus neurotoxin. Infect Immun (1975) 1.74
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia (1994) 1.73
Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Hum Gene Ther (1998) 1.72
Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. J Biol Chem (1998) 1.72
Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology (2001) 1.72
Ultrastructural studies of surface features of human normal and tumor cells in tissue culture by scanning and transmission electron microscopy. J Natl Cancer Inst (1976) 1.70
Recent dioxin contamination from Agent Orange in residents of a southern Vietnam city. J Occup Environ Med (2001) 1.68
Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol (1999) 1.66
Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch Surg (2001) 1.65
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant (2007) 1.64
Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ Res (2001) 1.63
Cross-protection against a lethal influenza virus infection by DNA vaccine to neuraminidase. Vaccine (2000) 1.63
Effects of injection rates of contrast material on arterial phase hepatic CT. AJR Am J Roentgenol (1998) 1.62
In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase. Biochem Biophys Res Commun (1989) 1.62
Isolation and characterization of mouse nasal-associated lymphoid tissue. J Immunol Methods (1997) 1.62
Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination. Vaccine (1990) 1.62
Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1992) 1.61
Role of oxygen-derived free radicals in myocardial edema and ischemia in coronary microvascular embolization. Circulation (1991) 1.60