Published in Biochemistry on September 21, 1999
Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem J (2004) 3.10
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol (2009) 2.76
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Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A (2006) 1.95
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol (2003) 1.75
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol (2003) 1.71
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Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A (2005) 1.49
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Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell (2010) 1.29
Extracellular proteins in pea root tip and border cell exudates. Plant Physiol (2006) 1.27
Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol (2005) 1.23
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Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis. Proc Natl Acad Sci U S A (2008) 1.18
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl Acad Sci U S A (2011) 1.12
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A comprehensive analysis of the 14-3-3 interactome in barley leaves using a complementary proteomics and two-hybrid approach. Plant Physiol (2006) 1.09
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Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth. Mol Biol Cell (2008) 1.05
14-3-3 proteins in neurological disorders. Int J Biochem Mol Biol (2012) 1.05
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14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. FASEB J (2009) 1.03
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases. Antioxid Redox Signal (2009) 1.01
Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem (2013) 1.01
Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration. PLoS One (2012) 1.01
Inhibition of the Arabidopsis salt overly sensitive pathway by 14-3-3 proteins. Plant Cell (2014) 0.99
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The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling. J Cell Biol (2011) 0.99
The Arabidopsis 14-3-3 protein RARE COLD INDUCIBLE 1A links low-temperature response and ethylene biosynthesis to regulate freezing tolerance and cold acclimation. Plant Cell (2014) 0.95
14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus. J Biol Chem (2011) 0.94
Phosphorylation-dependent C-terminal binding of 14-3-3 proteins promotes cell surface expression of HIV co-receptor GPR15. J Biol Chem (2010) 0.92
Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems. Mol Biol Cell (2006) 0.89
14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells. PLoS One (2012) 0.88
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. J Clin Invest (2012) 0.87
14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis. Plant Cell (2013) 0.87
IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proc Natl Acad Sci U S A (2014) 0.85
Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein. J Biol Chem (2012) 0.84
An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins. J Biol Chem (2011) 0.84
The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Mol Cell Biol (2012) 0.84
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs. Oncotarget (2014) 0.83
Phosphorylation of HopQ1, a type III effector from Pseudomonas syringae, creates a binding site for host 14-3-3 proteins. Plant Physiol (2013) 0.83
14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory. J Neurosci (2014) 0.83
The 14-3-3ζ protein binds to the cell adhesion molecule L1, promotes L1 phosphorylation by CKII and influences L1-dependent neurite outgrowth. PLoS One (2010) 0.82
A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors. Assay Drug Dev Technol (2013) 0.82
Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. Biol Psychiatry (2015) 0.81
Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal. Mol Biol Cell (2012) 0.81
Identification of a host 14-3-3 Protein that Interacts with Xanthomonas effector AvrRxv. Physiol Mol Plant Pathol (2008) 0.81
14-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR). J Biol Chem (2012) 0.80
Deletion of the cruciform binding domain in CBP/14-3-3 displays reduced origin binding and initiation of DNA replication in budding yeast. BMC Mol Biol (2007) 0.80
Plastid-nucleus communication involves calcium-modulated MAPK signalling. Nat Commun (2016) 0.80
14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity. Dev Neurobiol (2012) 0.79
A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides. Curr Chem Genomics (2008) 0.79
Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif. Eukaryot Cell (2013) 0.79
Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins. Am J Transl Res (2012) 0.79
Molecular mechanism of 14-3-3 protein-mediated inhibition of plant nitrate reductase. J Biol Chem (2011) 0.78
Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins. J Biol Chem (2013) 0.78
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14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem (2015) 0.76
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Migratory activation of parasitized dendritic cells by the protozoan Toxoplasma gondii 14-3-3 protein. Cell Microbiol (2016) 0.75
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