Published in Eur J Cell Biol on August 01, 1999
RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol (2003) 2.34
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal (2007) 1.65
Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation. J Cell Biol (2002) 1.27
Characterization and comparison of intercellular adherent junctions expressed by human corneal endothelial cells in vivo and in vitro. Invest Ophthalmol Vis Sci (2008) 1.12
Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol (2006) 1.12
Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol (2011) 1.10
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. Mol Cell Biol (2010) 1.01
P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res (2010) 0.98
Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A (2009) 0.98
The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol (2010) 0.95
RhoA GTPase inhibition organizes contraction during epithelial morphogenesis. J Cell Biol (2016) 0.88
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. J Immunol (2010) 0.88
Dental enamel structure is altered by expression of dominant negative RhoA in ameloblasts. Cells Tissues Organs (2011) 0.87
Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. J Cell Sci (2010) 0.86
PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. Biochim Biophys Acta (2009) 0.86
P190A RhoGAP is required for mammary gland development. Dev Biol (2011) 0.81
IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest (2014) 0.79
Ameloblasts require active RhoA to generate normal dental enamel. Eur J Oral Sci (2013) 0.79
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs. BMC Syst Biol (2015) 0.78
Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231. BMC Cancer (2012) 0.78
Imaging the effects of prostaglandin analogues on cultured trabecular meshwork cells by coherent anti-stokes Raman scattering. Invest Ophthalmol Vis Sci (2013) 0.77
Effects of gomisin A on vascular contraction in rat aortic rings. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.75
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene (2010) 9.66
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell (1997) 2.62
c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J Cell Biol (1995) 2.06
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev (1998) 1.97
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol (1993) 1.92
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91
Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation. EMBO J (1988) 1.89
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors. Cold Spring Harb Symp Quant Biol (2005) 1.78
The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization. Mol Cell Biol (1997) 1.78
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development (2000) 1.74
Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J Biol Chem (1994) 1.73
p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat Cell Biol (2001) 1.72
Rho family GTPases: more than simple switches. Trends Cell Biol (2000) 1.60
Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac. J Biol Chem (1994) 1.59
Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect. EMBO J (1995) 1.48
Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J (1997) 1.45
Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J Virol (1988) 1.40
Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity. J Virol (1990) 1.32
The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev (1999) 1.24
RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene (2000) 1.20
Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells. Cell Growth Differ (1998) 1.12
A model system for the rescue of cDNA encoding transacting transcription activator by contingent replication assay. Indian J Biochem Biophys (1988) 1.01
Relationship of multiple forms of chromogranin. J Biol Chem (1985) 1.01
Role of prenylation in the interaction of Rho-family small GTPases with GTPase activating proteins. Biochemistry (2001) 0.98
Regulation of NADPH oxidase activity by Rac GTPase activating protein(s). Mol Biol Cell (1993) 0.93
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly. Mol Cell Biol (1994) 0.93
E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells. Oncogene (1998) 0.93
Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride. Proc Natl Acad Sci U S A (1998) 0.92
MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase. J Biol Chem (2000) 0.90
Chromogranin, an integral membrane protein. J Biol Chem (1985) 0.88
Getting in shape with Rho. Nat Cell Biol (2000) 0.87
The role of rho family GTPases in development: lessons from Drosophila melanogaster. Mol Cell Biol Res Commun (1999) 0.85
P190A RhoGAP is required for mammary gland development. Dev Biol (2011) 0.81
Genetic definition of a new bovine papillomavirus type 1 open reading frame, E5B, that encodes a hydrophobic protein involved in altering host-cell protein processing. J Virol (1993) 0.79
Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells. Cell Growth Differ (1995) 0.79
Emerging concepts in tumor progression and therapy. Semin Cancer Biol (2000) 0.78
Structure, activity, and regulation of the bovine papillomavirus E5 gene and its transforming protein product. Curr Top Microbiol Immunol (1989) 0.77
Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins. Virology (1990) 0.75