Rat TRH receptor type 2 exhibits higher basal signaling activity than TRH receptor type 1.

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Published in Endocrinology on October 01, 1999

Authors

W Wang1, M C Gershengorn

Author Affiliations

1: Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021-4896, USA.

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G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature (1998) 5.24

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Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action. Biochem J (1983) 1.72

Serum triiodothyronine: measurements in human serum by radioimmunoassay with corroboration by gas-liquid chromatography. J Clin Invest (1971) 1.54

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Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH". J Clin Invest (1975) 1.49

Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion. Annu Rev Physiol (1986) 1.43

Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells. J Biol Chem (1986) 1.34

Calcium influx is not required for TRH to elevate free cytoplasmic calcium in GH3 cells. Endocrinology (1983) 1.33

Phosphatidylinositol 4,5-bisphosphate turnover is transient while phosphatidylinositol turnover is persistent in thyrotropin-releasing hormone-stimulated rat pituitary cells. Proc Natl Acad Sci U S A (1986) 1.32

Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. J Exp Med (1998) 1.32

Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum. Nature (1987) 1.30

The sterols of Ochromonas danica and Ochromonas malhamensis. Biochemistry (1968) 1.29

Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion. J Biol Chem (1983) 1.27

Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells. J Biol Chem (1984) 1.22

Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A (1990) 1.15

Thyrotropin-releasing hormone receptors -- similarities and differences. J Mol Endocrinol (2003) 1.15

Fine-needle aspiration cytology in the preoperative diagnosis of thyroid nodules. Ann Intern Med (1977) 1.11

Thyroxine transport proteins of plasma. Molecular properties and biosynthesis. Recent Prog Horm Res (1978) 1.10

Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells. J Biol Chem (2001) 1.09

Decreased TRH receptor mRNA activity precedes homologous downregulation: assay in oocytes. Science (1987) 1.07

Evidence for tight coupling of thyrotropin-releasing hormone receptors to stimulated inositol trisphosphate formation in rat pituitary cells. J Biol Chem (1985) 1.07

Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors. J Clin Endocrinol Metab (1977) 1.05

Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture. J Exp Med (1998) 1.05

Agonist-stimulated internalization of the thyrotropin-releasing hormone receptor is dependent on two domains in the receptor carboxyl terminus. J Biol Chem (1993) 1.03

Measurement of lipid turnover in response to thyrotropin-releasing hormone. Methods Enzymol (1987) 1.02

Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Proc Natl Acad Sci U S A (1995) 1.02

Thyrotropin releasing hormone. A review of the mechanisms of acute stimulation of pituitary hormone release. Mol Cell Biochem (1982) 1.01

Mechanism of membrane electrical response to thyrotropin-releasing hormone in Xenopus oocytes injected with GH3 pituitary cell messenger ribonucleic acid. Mol Endocrinol (1987) 1.01

Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1alpha inhibit signaling by KSHV G protein-coupled receptor. Biochem Biophys Res Commun (1998) 0.98

Thyrotropin releasing hormone rapidly enhances [32P]orthophosphate incorporation into phosphatidic acid in cloned GH3 cells. Biochem Biophys Res Commun (1981) 0.95

TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. Mol Endocrinol (2000) 0.95

Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor. Biophys J (1998) 0.95

Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes. J Biol Chem (1994) 0.94

Thyrotropin-releasing hormone causes loss of cellular calcium without calcium uptake by rat pituitary cells in culture. Studies using arsenazo III for direct measurement of calcium. J Biol Chem (1982) 0.94

Regulation by phosphatidylinositol of rat pituitary plasma membrane and endoplasmic reticulum phosphatidylinositol synthase activities. A mechanism for activation of phosphoinositide resynthesis during cell stimulation. J Biol Chem (1987) 0.94

Evidence that stimulation of thyrotropin and prolactin secretion by thyrotropin-releasing hormone occur via different calcium-mediated mechanisms: studies with verapamil. Endocrinology (1982) 0.94

Arachidonic acid mobilizes calcium and stimulates prolactin secretion from GH3 cells. Am J Physiol (1984) 0.94

Thyrotropin-releasing hormone (TRH) stimulates biphasic elevation of cytoplasmic free calcium in GH3 cells. Further evidence that TRH mobilizes cellular and extracellular Ca2+. Endocrinology (1985) 0.94

Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone. Biochemistry (1997) 0.94

Charged residues at the intracellular boundary of transmembrane helices 2 and 3 independently affect constitutive activity of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. J Biol Chem (2001) 0.93

Bihormonal regulation of the thyrotropin-releasing hormone receptor in mouse pituitary thyrotropic tumor cells in culture. J Clin Invest (1978) 0.91

Thyroid-stimulating hormone and insulin-like growth factor-1 synergize to elevate 1,2-diacylglycerol in rat thyroid cells. Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems. J Clin Invest (1988) 0.91

Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C. J Biol Chem (1988) 0.90

Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. J Biol Chem (1994) 0.90

Analysis by base exchange of thyrotropin-releasing hormone responsive and unresponsive inositol lipid pools in rat pituitary tumor cells. J Biol Chem (1990) 0.90

Characterization of human thyroxine-binding globulin. Evidence for a single polypeptide chain. J Biol Chem (1977) 0.89

Differences in receptor-evoked membrane electrical responses in native and mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 0.89

Use of lithium as an adjunct to radioiodine therapy of thyroid carcinoma. J Clin Endocrinol Metab (1976) 0.88

The N terminus of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity. J Biol Chem (1999) 0.88

A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist. Mol Endocrinol (1995) 0.88

Thyrotropin-releasing hormone stimulation of prolactin release from clonal rat pituitary cells: evidence for action independent of extracellular calcium. J Clin Invest (1981) 0.88

A disulfide bond between conserved extracellular cysteines in the thyrotropin-releasing hormone receptor is critical for binding. J Biol Chem (1995) 0.87

Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells. J Biol Chem (1984) 0.87

Estrogens increase the number of thyrotropin-releasing hormone receptors on mammotropic cells in culture. Endocrinology (1979) 0.87

Excess production of free alpha subunits by mouse pituitary thyrotropic tumor cells in vitro. Endocrinology (1978) 0.87

Constitutively signaling G-protein-coupled receptors and human disease. Trends Endocrinol Metab (2008) 0.86

Radioimmunoassay for serum thyroxine-binding globulin: results in normal subjects and in patients with hepatocellular carcinoma. J Clin Endocrinol Metab (1976) 0.86

Evidence for tight coupling of receptor occupancy by thyrotropin-releasing hormone to phospholipase C-mediated phosphoinositide hydrolysis in rat pituitary cells: use of chlordiazepoxide as a competitive antagonist. Endocrinology (1986) 0.86

Phosphatidylinositol depletion in GH3 rat pituitary cells inhibits sustained responses to thyrotropin-releasing hormone. Reversal with myo-inositol. Mol Endocrinol (1987) 0.86

Thyrotropin releasing hormone stimulation of prolactin release. Evidence for a membrane potential-independent, Ca2+-dependent mechanism of action. J Biol Chem (1980) 0.86

Effects of estrogen on thyroxine-binding globulin metabolism in rhesus monkeys. Endocrinology (1977) 0.85

Glycosylation is important for binding to human calcitonin receptors. Biochemistry (1999) 0.85

A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation. Mol Pharmacol (1998) 0.85

Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor. J Biol Chem (1997) 0.85

Thyrotropin-releasing hormone action: mechanism of calcium-mediated stimulation of prolactin secretion. Recent Prog Horm Res (1985) 0.85

Constitutive activity of native thyrotropin-releasing hormone receptors revealed using a protein kinase C-responsive reporter gene. Endocrinology (1997) 0.85

Thyrotropin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors. J Biol Chem (1992) 0.85

Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin-releasing hormone desensitization is cell specific. Mol Pharmacol (1994) 0.85

Small molecule TSHR agonists and antagonists. Ann Endocrinol (Paris) (2011) 0.84

Characterization of a salt-extractable phosphatidylinositol synthase from rat pituitary-tumour membranes. Biochem J (1989) 0.84

A model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Evidence for a second direct interaction between transmembrane helix 3 and TRH. J Biol Chem (1994) 0.84

Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor. Endocrinology (1995) 0.84

Thyrotropin-releasing hormone: evidence for thyroid response to intravenous injection in man. Science (1972) 0.83

Regulation of thyrotropin production by mouse pituitary thyrotropic tumor cells in vitro by physiological levels of thyroid hormones. Endocrinology (1978) 0.83

Direct evidence that burst but not sustained secretion of prolactin stimulated by thyrotropin-releasing hormone is dependent on elevation of cytoplasmic calcium. J Biol Chem (1985) 0.83

Direct human T helper cell-induced B cell activation is not mediated by inositol lipid hydrolysis. J Immunol (1988) 0.83

Truncation of the thyrotropin-releasing hormone receptor carboxyl tail causes constitutive activity and leads to impaired responsiveness in Xenopus oocytes and AtT20 cells. J Biol Chem (1995) 0.83

Decreased levels of internalized thyrotropin-releasing hormone receptors after uncoupling from guanine nucleotide-binding protein and phospholipase-C. Mol Endocrinol (1993) 0.82

Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels. Mol Endocrinol (1992) 0.82

Thyrotropin-releasing hormone analogs. Mini Rev Med Chem (2006) 0.82

Subcellular organization of receptor-mediated phosphoinositide turnover. Endocr Rev (1992) 0.82

Stimulation of thyroxine-binding globulin synthesis by isolated rhesus monkey hepatocytes after in vivo beta-estradiol administration. Endocrinology (1977) 0.82

Human calcitonin receptors exhibit agonist-independent (constitutive) signaling activity. Endocrinology (1997) 0.82

Thyroxine-binding globulin biosynthesis in isolated monkey hepatocytes. Biochim Biophys Acta (1976) 0.82

Receptor density determines secretory response patterns mediate by inositol lipid-derived second messengers. Comparison of thyrotropin-releasing hormone and carbamylcholine actions in thyroid-stimulating hormone-secreting mouse pituitary tumor cells. J Biol Chem (1989) 0.81

Latency in the inositol lipid transduction pathway: the role of cellular events in responses to thyrotropin-releasing hormone in Xenopus oocytes. Pflugers Arch (1993) 0.81

Thyrotropin-releasing hormone receptor occupancy determines the fraction of the responsive pool of inositol lipids hydrolysed in rat pituitary tumour cells. Biochem J (1990) 0.81

Arachidonic acid inhibits thyrotropin-releasing hormone-induced elevation of cytoplasmic free calcium in GH3 pituitary cells. J Biol Chem (1985) 0.81

Receptor number determines latency and amplitude of the thyrotropin-releasing hormone response in Xenopus oocytes injected with pituitary RNA. Mol Endocrinol (1989) 0.81

Desensitization of the response to thyrotropin-releasing hormone in Xenopus oocytes is an amplified process that precedes calcium mobilization. Pflugers Arch (1995) 0.81

Tetracaine, propranolol and trifluoperazine inhibit thyrotropin releasing hormone-induced prolactin secretion from GH3 cells by displacing membrane calcium: further evidence that TRH acts to mobilize cellular calcium. Endocrinology (1982) 0.80

Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells. J Biol Chem (1992) 0.80

Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect. Mol Endocrinol (1991) 0.80

A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry (1996) 0.80

Activation of two different receptors mobilizes calcium from distinct stores in Xenopus oocytes. Biophys J (1990) 0.80

Differential regulation by phosphatidylinositol 4,5-bisphosphate of pituitary plasma-membrane and cytosolic phosphoinositide kinases. Biochem J (1986) 0.80

Thyrotropin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium. Endocrinology (1991) 0.80

Differential effects of cytoskeletal agents on hemispheric functional expression of cell membrane receptors in Xenopus oocytes. Cell Mol Neurobiol (1993) 0.80

Polarity of TRH receptors in transfected MDCK cells is independent of endocytosis signals and G protein coupling. Am J Physiol (1996) 0.80