Published in EMBO J on October 01, 1999
Bioactive sphingolipids: metabolism and function. J Lipid Res (2008) 2.73
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56
The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest (2002) 2.30
Cathepsin D--many functions of one aspartic protease. Crit Rev Oncol Hematol (2008) 2.26
The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal (2007) 2.16
Ceramide: second messenger or modulator of membrane structure and dynamics? Biochem J (2003) 2.06
Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J (2001) 1.80
Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer (2012) 1.79
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol (2006) 1.66
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta (2006) 1.65
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J (2008) 1.56
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53
Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46
Sphingolipids: regulators of crosstalk between apoptosis and autophagy. J Lipid Res (2012) 1.40
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol (2008) 1.35
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.27
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol (2010) 1.24
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology (2009) 1.23
Ceramide function in the brain: when a slight tilt is enough. Cell Mol Life Sci (2012) 1.12
Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12
Lipid metabolism, apoptosis and cancer therapy. Int J Mol Sci (2015) 1.11
Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol (2010) 1.09
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem (2008) 1.09
Involvement of FAN in TNF-induced apoptosis. J Clin Invest (2001) 1.08
Apoptosis and necrosis in the liver. Compr Physiol (2013) 1.05
Ceramide and mitochondria in ischemia/reperfusion. J Cardiovasc Pharmacol (2009) 1.04
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. EMBO J (2010) 0.99
Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders. Philos Trans R Soc Lond B Biol Sci (2003) 0.99
Apoptotic sphingolipid ceramide in cancer therapy. J Lipids (2011) 0.97
Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid. Invest Ophthalmol Vis Sci (2010) 0.95
Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation. Biochem J (2004) 0.93
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Ceramide signaling in mammalian epidermis. Biochim Biophys Acta (2013) 0.92
Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Front Physiol (2014) 0.91
Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One (2012) 0.89
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res (2010) 0.88
Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells. J Proteomics (2009) 0.86
Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium. Infect Immun (2007) 0.85
Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84
Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon. Biol Med (Aligarh) (2014) 0.83
Procathepsin D and cancer: From molecular biology to clinical applications. World J Clin Oncol (2010) 0.83
Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes. Cancer Biol Ther (2012) 0.83
Interdiction of sphingolipid metabolism to improve standard cancer therapies. Adv Cancer Res (2013) 0.81
Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide. Int J Biol Sci (2011) 0.81
Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. Cell Death Differ (2014) 0.81
SapC-DOPS nanovesicles: a novel targeted agent for the imaging and treatment of glioblastoma. Oncoscience (2015) 0.80
Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. Mol Cell Biol (2014) 0.79
Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis. Cell Death Dis (2015) 0.78
The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis. Open Respir Med J (2010) 0.78
Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity. J Cell Biochem (2017) 0.77
Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology. Mol Cell Proteomics (2016) 0.77
Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. PLoS One (2016) 0.76
Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing. Mol Cell Proteomics (2016) 0.76
Relating toxicity to transfection: using sphingosine to maintain prolonged expression in vitro. Mol Pharm (2014) 0.75
Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. Oncotarget (2016) 0.75
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death. Oncotarget (2016) 0.75
Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis. PLoS One (2016) 0.75
Protein kinase C-δ isoform mediates lysosome labilization in DNA damage-induced apoptosis. Int J Oncol (2010) 0.75
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature (1998) 7.43
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature (1984) 7.37
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature (1993) 6.75
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature (2000) 6.34
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A (1984) 4.90
TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell (1992) 4.54
mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J (2000) 4.06
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (1998) 3.98
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol (1999) 3.80
Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene. Proc Natl Acad Sci U S A (1985) 3.74
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest (2000) 3.58
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest (2000) 3.47
Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain. Proc Natl Acad Sci U S A (1999) 3.16
Sequential expression of genes involved in human T lymphocyte growth and differentiation. J Exp Med (1985) 3.04
Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood (2001) 2.99
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol (2000) 2.91
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A (1999) 2.82
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A (1994) 2.79
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A (1998) 2.75
YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. EMBO J (2000) 2.70
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell (1994) 2.68
Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endocrinol Metab (2000) 2.68
Functional architecture of an intracellular membrane t-SNARE. Nature (2000) 2.57
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature (1998) 2.56
Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56
Genetics of quantitative variation in human gene expression. Cold Spring Harb Symp Quant Biol (2003) 2.55
Regulation of ceramide production and apoptosis. Annu Rev Physiol (1998) 2.54
A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A (1994) 2.51
The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell (2000) 2.46
Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. Lancet (1996) 2.45
Structure of the human interleukin-2 receptor gene. Science (1985) 2.43
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease. Ann Neurol (1998) 2.35
Single bilayer vesicles prepared without sonication. Physico-chemical properties. Biochim Biophys Acta (1976) 2.32
STN-DBS activates the target area in Parkinson disease: an FDG-PET study. Neurology (2008) 2.27
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer. Cell (1995) 2.27
Separation of lymphocyte-stimulating and agglutinating activities in phytohaemagglutinin (PHA) from Phaseolus vulgaris. Scand J Haematol (1967) 2.22
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci (2000) 2.21
Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen. J Immunol (1984) 2.20
A new oscillometric method for pulse wave analysis: comparison with a common tonometric method. J Hum Hypertens (2010) 2.19
A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature (1989) 2.18
Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study. BMJ (1998) 2.15
FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell (1996) 2.15
The overactive bladder in childhood: long-term results with conservative management. J Urol (2000) 2.14
Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region. Am J Hum Genet (1998) 2.09
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J (2000) 2.09
Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort. Arch Dis Child Fetal Neonatal Ed (2008) 2.07
[Patient knowledge concerning anesthesia general practice and the responsibilities of the anesthetist]. Anasthesiol Intensivmed Notfallmed Schmerzther (1996) 2.06
Randomised trial of cervical cerclage, with and without occlusion, for the prevention of preterm birth in women suspected for cervical insufficiency. BJOG (2013) 2.00
First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00
Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant (2009) 2.00
Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab (2000) 1.99
Augmented T cell growth factor receptor expression in HTLV-1-infected human leukemic T cells. J Immunol (1984) 1.99
The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion. Mol Cell (1999) 1.99
Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy. Lancet (2000) 1.98
Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid. EMBO J (1992) 1.97
The EBMT activity survey: 1990-2010. Bone Marrow Transplant (2012) 1.96
Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the "fusion peptide". J Biol Chem (1989) 1.96
Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs. Proc Natl Acad Sci U S A (1999) 1.95
Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. Lancet (1996) 1.91
The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. The EU Concerted Action on Virus Meningitis and Encephalitis. J Neurol Neurosurg Psychiatry (1996) 1.87
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor. J Biol Chem (1990) 1.87
Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention. Bone Marrow Transplant (2004) 1.84
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem (1999) 1.82
Photolabeling identifies a putative fusion domain in the envelope glycoprotein of rabies and vesicular stomatitis viruses. J Biol Chem (1995) 1.80
Interleukin 2 receptor gene expression in normal human T lymphocytes. Proc Natl Acad Sci U S A (1985) 1.80
Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG (2000) 1.78
Role of the regulatory gene pl in the photocontrol of maize anthocyanin pigmentation. Plant Cell (1993) 1.78
Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells. J Immunol (1987) 1.78
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. J Biol Chem (2001) 1.76
Wolman disease successfully treated by bone marrow transplantation. Bone Marrow Transplant (2000) 1.75
Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration. J Immunol (1996) 1.73
Tumor necrosis factor receptor-mediated signaling pathways. J Cell Biol (1994) 1.72
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn. Cell (1991) 1.72
Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurosci Lett (1997) 1.71
Molecular mechanism of membrane protein integration into the endoplasmic reticulum. Cell (1997) 1.70
Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. J Biol Chem (1999) 1.70
Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene (2000) 1.69
Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor. EMBO J (2000) 1.68
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation (2005) 1.66
Detection and purification of a recombinant human B lymphotropic virus (HHV-6) in the baculovirus expression system by limiting dilution and DNA dot-blot hybridization. J Virol Methods (1988) 1.65
Early embryonic death of mice deficient in gamma-adaptin. J Biol Chem (1999) 1.64
Membrane interaction of influenza virus M1 protein. Virology (2000) 1.63
Parthenogenesis in Xenopus eggs requires centrosomal integrity. J Cell Biol (1990) 1.62
Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95. European Union (EU) Collaborative Study Group of Creutzfeldt-Jakob disease (CJD). Lancet (1998) 1.60
Bone marrow transplantation for globoid cell leukodystrophy, adrenoleukodystrophy, metachromatic leukodystrophy, and Hurler syndrome. Curr Opin Hematol (1999) 1.59
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ (2004) 1.59
Incidence of Creutzfeldt-Jakob disease in Europe in 1993. Lancet (1994) 1.59
Hosts as ecological traps for the vector of Lyme disease. Proc Biol Sci (2009) 1.59