Published in Mol Cell Biol on November 01, 1999
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol (2001) 2.72
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci U S A (2000) 2.29
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol (2001) 2.09
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol (2003) 1.99
Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection. Bipolar Disord (2002) 1.50
Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload. J Clin Invest (2002) 1.43
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
The roles of integrin-linked kinase in the regulation of myogenic differentiation. J Cell Biol (2000) 1.24
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J (2005) 1.23
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol (2011) 1.16
FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability. Mol Biol Cell (2007) 1.07
Cell adhesion molecules in chemically-induced renal injury. Pharmacol Ther (2007) 1.06
Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1. Oncogene (2010) 1.01
RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res (2005) 1.00
Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro. Br J Cancer (2003) 0.99
Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target. Cancer Res (2009) 0.95
Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. Mol Pharmacol (2009) 0.94
Integrin signalling and the cellular response to ionizing radiation. J Mol Histol (2004) 0.87
Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism. PLoS One (2014) 0.86
LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. J Cell Sci (2009) 0.85
Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism. Mol Cancer Res (2009) 0.85
Bromelain reversibly inhibits invasive properties of glioma cells. Neoplasia (2002) 0.85
Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. J Biol Chem (2014) 0.80
Integrin-linked kinase in gastric cancer cell attachment, invasion and tumor growth. World J Gastroenterol (2011) 0.79
Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK). Transl Oncogenomics (2007) 0.79
PARVA promotes metastasis by modulating ILK signalling pathway in lung adenocarcinoma. PLoS One (2015) 0.78
Agmatine Protects Against 6-OHDA-Induced Apoptosis, and ERK and Akt/GSK Disruption in SH-SY5Y Cells. Cell Mol Neurobiol (2015) 0.77
ILK-PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast. Lab Invest (2016) 0.75
Correlation between PKB/Akt, GSK-3β expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection. Exp Ther Med (2017) 0.75
Roles of galactose 3'-O- sulfation in signaling. Glycoconj J (2014) 0.75
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem (1987) 59.79
Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93
The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem (1994) 14.36
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res (1991) 13.54
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev (1998) 12.55
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta (1991) 11.78
Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
The MAPK signaling cascade. FASEB J (1995) 10.81
Integrins and signal transduction pathways: the road taken. Science (1995) 10.71
A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A (1995) 10.25
The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem (1995) 8.32
AP-1 function and regulation. Curr Opin Cell Biol (1997) 8.29
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J (1997) 6.14
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature (1996) 6.02
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A (1998) 5.98
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med (Berl) (1996) 5.77
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J (1993) 5.53
Integrins and anoikis. Curr Opin Cell Biol (1997) 5.38
Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev (1996) 5.20
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem (1998) 5.09
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol (1987) 4.86
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature (1991) 4.74
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (1991) 4.17
MAPKs: new JNK expands the group. Trends Biochem Sci (1994) 4.10
Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays (1996) 3.96
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A (1998) 3.35
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol (1992) 2.91
Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol (1999) 2.91
Integrins, oncogenes, and anchorage independence. J Cell Biol (1997) 2.86
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol (1997) 2.67
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell (1992) 2.62
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes. J Biol Chem (1992) 2.57
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Growth factor activation of MAP kinase requires cell adhesion. EMBO J (1997) 2.47
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem (1997) 2.47
Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB. J Biol Chem (1998) 2.22
Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene (1993) 1.73
Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J (1994) 1.61
Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Mol Cell Biol (1996) 1.44
Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy. Oncogene (1993) 1.29
Inducible regulatory elements in the human cyclin D1 promoter. Oncogene (1994) 1.23
Integrins and signal transduction. Curr Opin Hematol (1999) 1.18
Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site. J Biol Chem (1999) 0.93
Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation. J Biol Chem (1997) 0.93
Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites. Proc Natl Acad Sci U S A (1992) 0.91
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature (1996) 6.02
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A (1998) 5.98
Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A (1998) 5.34
Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells. J Cell Sci (1991) 4.18
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A (1998) 3.35
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem (2001) 3.32
Clinical findings of West Nile virus infection in hospitalized patients, New York and New Jersey, 2000. Emerg Infect Dis (2001) 2.97
Alvarado score: an admission criterion in patients with right iliac fossa pain. Surgeon (2003) 2.77
Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol (2001) 2.54
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem (1998) 2.50
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem (1997) 2.47
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci U S A (2000) 2.29
Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature (1997) 2.21
Ethnic differences in acute myocardial infarction in Singapore. Eur Heart J (2003) 2.20
Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene (2001) 2.16
Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J Cell Biol (2001) 2.09
A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence. J Cell Biol (1987) 2.04
The effects of plasmalyte-148 vs. Hartmann's solution during major liver resection: a multicentre, double-blind, randomized controlled trial. Minerva Anestesiol (2014) 2.01
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene (2009) 2.01
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91
Signaling through beta-catenin and Lef/Tcf. Cell Mol Life Sci (1999) 1.83
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem (2000) 1.77
Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer (1967) 1.69
Optic neuritis in Singapore. Singapore Med J (2008) 1.65
The integrin-linked kinase (ILK) suppresses anoikis. Oncogene (2000) 1.59
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene (2006) 1.59
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene (2000) 1.58
Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer (2003) 1.57
Development of a new intensive therapy for acute lymphoblastic leukemia in children at increased risk of early relapse. The Memorial Sloan-Kettering-New York-II protocol. Cancer (1993) 1.51
High-dose methotrexate with citrovorum factor rescue and adriamycin in childhood osteogenic sarcoma. Cancer (1974) 1.44
Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene (2001) 1.42
Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. Development (1998) 1.33
Proceedings: Disease-free survival in children with Ewing's sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy. Cancer (1974) 1.31
Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. J Cell Biol (1995) 1.31
Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells. J Biol Chem (1993) 1.31
E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children. Cancer (1970) 1.31
Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes. J Exp Med (1998) 1.30
Ecotaxis: the principle and its application to the study of Hodgkin's disease. Clin Exp Immunol (1977) 1.29
The isolation and amino acid/sugar composition of human fibroblastoid interferon. J Biol Chem (1979) 1.28
Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene (2006) 1.26
In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry (1991) 1.26
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene (2012) 1.24
Integrin-linked kinase: not so 'pseudo' after all. Oncogene (2011) 1.24
Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res (2000) 1.24
Regulation of neutrophil activation in acute lung injury. Chest (1999) 1.23
Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese. J Neurol Sci (2003) 1.23
Primary cutaneous aspergillosis associated with Hickman intravenous catheters. N Engl J Med (1987) 1.23
Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrin. J Biol Chem (1995) 1.22
Integrin expression in human bone. J Bone Miner Res (1993) 1.21
Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg (1990) 1.20
Bi-directional signal transduction by integrin receptors. Int J Biochem Cell Biol (2000) 1.20
Use of inflammatory markers to guide cancer treatment. Clin Pharmacol Ther (2011) 1.18
Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin alpha-subunit-binding protein. J Cell Sci (1994) 1.15
Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J Cell Sci (2001) 1.14
Purification and in vitro labeling of interferon from a human fibroblastoid cell line. J Biol Chem (1978) 1.13
The rationale for multiple drug chemotherapy in the treatment of osteogenic sarcoma. Cancer (1975) 1.13
Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT). Oncogene (2012) 1.12
Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors. Cancer Res (1990) 1.12
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene (2010) 1.12
Correction of constriction rings. J Hand Surg Am (1991) 1.11
A prospective randomized controlled trial of suction versus non-suction to the under-water seal drains following lung resection. Eur J Cardiothorac Surg (2005) 1.11
A role for frizzled 3 in neural crest development. Development (2001) 1.11
Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene (2001) 1.10
Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. J Neuroimmunol (1991) 1.10
Review of orbital imaging. Eur J Radiol (2008) 1.10
Adriamycin--an antitumor antibiotic in the treatment of neoplastic diseases. Cancer (1973) 1.10
Calreticulin. Int J Biochem Cell Biol (1998) 1.09
Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of alpha 3 and alpha 6 integrins. J Cell Sci (1995) 1.09
Cardiac failure and dysrhythmias 6-19 years after anthracycline therapy: a series of 15 patients. Med Pediatr Oncol (1995) 1.09
Rat seminiferous epithelium contains a unique junction (Ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions. Biol Reprod (2001) 1.06
Xerostomia: an update for clinicians. Aust Dent J (2010) 1.06
Integrin-linked kinase (ILK): a "hot" therapeutic target. Biochem Pharmacol (2000) 1.05
Regulation of eye development by frizzled signaling in Xenopus. Proc Natl Acad Sci U S A (2001) 1.04
Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix. Exp Cell Res (1994) 1.03
Molecular cloning and characterization of a new receptor for galanin. FEBS Lett (1997) 1.03
Suggested models of ecotaxopathy in lymphoreticular malignancy. A role for iron-binding proteins in the control of lymphoid cell migration. Am J Pathol (1978) 1.02
Consumer-operated drop-in centers: evaluation of operations and impact. J Ment Health Adm (1993) 1.02
Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1. Oncogene (2010) 1.01
Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia (2010) 1.01
Primary colorectal sarcoma. A retrospective review and prognostic factor study of 50 consecutive patients. Arch Surg (1990) 1.00
Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Oncogene (2010) 1.00
Structuring a safer donor-replacement program. Transfusion (1998) 1.00
Usefulness of serum lipase, esterase, and amylase estimation in the diagnosis of pancreatitis--a comparison. Clin Chem (1970) 0.99
Unusual features of the Drosophila melanogaster telomere transposable element HeT-A are conserved in Drosophila yakuba telomere elements. Proc Natl Acad Sci U S A (1998) 0.99
Fragile X premutation alleles in SCA, ET, and parkinsonism in an Asian cohort. Neurology (2004) 0.98
Urinary N-acetyl-beta-D-glucosaminidase activity in workers exposed to inorganic lead. Occup Environ Med (1994) 0.98
Influence of age and gender on thoracic vertebral body shape and disc degeneration: an MR investigation of 169 cases. J Anat (2000) 0.97
Immunostaining of human brain capillaries by antibodies to very late antigens. J Neuroimmunol (1990) 0.97
Impact of diagnostic procedures on patient management and hospitalization cost during the 2000 and 2005 enterovirus epidemics in Marseilles, France. Clin Microbiol Infect (2009) 0.97
Transformation-associated alterations in interactions between pre-B cells and fibronectin. Blood (1990) 0.96
Growth hormone secretagogue receptor family members and ligands. Endocrine (2001) 0.95
Inhibition of RNA polymerase I transcription in differentiated myeloid leukemia cells by inactivation of selectivity factor 1. Cell Growth Differ (2000) 0.95
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. Leukemia (1993) 0.95
Gonadal function in young patients successfully treated for Hodgkin disease. Med Pediatr Oncol (1999) 0.95